BE807654A - 6-Alpha-deoxy-tetracyclines prodn - by redn of 6-methylene-tetracyclines using soluble noble metal-ligand complexes as catalysts - Google Patents
6-Alpha-deoxy-tetracyclines prodn - by redn of 6-methylene-tetracyclines using soluble noble metal-ligand complexes as catalystsInfo
- Publication number
- BE807654A BE807654A BE138034A BE138034A BE807654A BE 807654 A BE807654 A BE 807654A BE 138034 A BE138034 A BE 138034A BE 138034 A BE138034 A BE 138034A BE 807654 A BE807654 A BE 807654A
- Authority
- BE
- Belgium
- Prior art keywords
- tetracyclines
- methylene
- catalysts
- redn
- prodn
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The title cpds. of formula (I):- (where Y is H, F, Cl, Br or I, and R is H, OH or OCOR', where R' is 1-6C alkyl) are prepd. by homogeneous catalytic hydrogeneration of the corresp. 6-methylene cpds. in the presence of catalysts soluble in the reaction medium which are complexes of noble metals selected from Rh, Ru, Os, Ir, Pt and Ni with ligands selected from triphenylphosphine, triphenylarsine, triphenylstibine, tributylphosphine, triethylphosphine, diethylphenylphosphine and diphenylethylphosphine, in a polar solvent selected from 1-4C mono- or poly-hydroxylated alcohols, DMF, N,('-dimethylacetamide dioxane, THF, methoxyethanol, ethoxyethanol, CH3CN and pyridine, at 15-80 degrees C for 1-8 hrs. in the presence of H2 at a pressure of 1-150 kg/cm2. 6alpha-deoxytetracyclines are known antibiotics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE138034A BE807654A (en) | 1973-11-22 | 1973-11-22 | 6-Alpha-deoxy-tetracyclines prodn - by redn of 6-methylene-tetracyclines using soluble noble metal-ligand complexes as catalysts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE138034A BE807654A (en) | 1973-11-22 | 1973-11-22 | 6-Alpha-deoxy-tetracyclines prodn - by redn of 6-methylene-tetracyclines using soluble noble metal-ligand complexes as catalysts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE807654A true BE807654A (en) | 1974-03-15 |
Family
ID=3842375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE138034A BE807654A (en) | 1973-11-22 | 1973-11-22 | 6-Alpha-deoxy-tetracyclines prodn - by redn of 6-methylene-tetracyclines using soluble noble metal-ligand complexes as catalysts |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE807654A (en) |
-
1973
- 1973-11-22 BE BE138034A patent/BE807654A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tsuji | Carbon-carbon bond formation via palladium complexes | |
| Bruneau et al. | Selective transformations of alkynes with ruthenium catalysts | |
| FR2198901A1 (en) | Aq solns of cobalt carbonyls for catalysis - are prepd by reacting aq cobalt salt solns with CO and hydrogen with polar solvent | |
| AU445977B2 (en) | Engine constant rate exhaust gas recirculation system | |
| AU476179B2 (en) | Exhaust gas recirculation flow control system | |
| CH609321A5 (en) | Process for the preparation of carboxylic acid anhydrides | |
| NL157812B (en) | PROCEDURE FOR PREPARING A CATALYST FOR OXYDERING CARBON MONOXIDE. | |
| ES421313A1 (en) | Cycloheptaamylose-silver alkanol ammine complex compound | |
| BE807654A (en) | 6-Alpha-deoxy-tetracyclines prodn - by redn of 6-methylene-tetracyclines using soluble noble metal-ligand complexes as catalysts | |
| CA1033239A (en) | Engine air pump pressure/manifold vacuum controlled exhaust gas recirculating control system | |
| US4027084A (en) | Polymeric diphosphorous coordinates and their metal derivatives | |
| GB1424629A (en) | Process for preparing a ruthenium catalyst and product produced thereby | |
| Braca et al. | Role and effect of promoters of the ruthenium catalysts in the homologation of methyl acetate to ethyl acetate | |
| ES411982A1 (en) | Process for the preparation of alpha-6-deoxytetracyclines | |
| ES308313A1 (en) | Procedure for the preparation of aldehydes and non-saturated acids and catalyst for their realization. (Machine-translation by Google Translate, not legally binding) | |
| GB1498784A (en) | Process for producing terephthalic acid | |
| ES351848A1 (en) | Process for preparing vinyl acetate | |
| GB1358785A (en) | Highly active silver catalysts | |
| FR2086903A5 (en) | Hydrocarbon steam-reforming catalyst - with spinel support | |
| GB1324048A (en) | Process and catalyst for the polymerization of conjugated dienes | |
| BE794803A (en) | Acetic acid prepn - from methanol and carbon monoxide using rhodium-contg catalyst | |
| GB1345627A (en) | Prime movers | |
| GB1105146A (en) | Process for preparing mixtures of acetaldehyde, acetic acid and vinyl acetate | |
| FR2054084A5 (en) | Alkenyl acetates from alkenes, oxygen - and acetic acid | |
| GB1149449A (en) | Regeneration of catalyst for making vinyl acetate |