ES409727A1 - Carboxylic acid derivatives and processes for their p'eparation - Google Patents

Carboxylic acid derivatives and processes for their p'eparation

Info

Publication number
ES409727A1
ES409727A1 ES409727A ES409727A ES409727A1 ES 409727 A1 ES409727 A1 ES 409727A1 ES 409727 A ES409727 A ES 409727A ES 409727 A ES409727 A ES 409727A ES 409727 A1 ES409727 A1 ES 409727A1
Authority
ES
Spain
Prior art keywords
formula
compound
indicated above
meanings indicated
signify
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES409727A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES409727A1 publication Critical patent/ES409727A1/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedure for obtaining carboxylic acid derivatives, of general formula **(See formula)** where Z1 and Z2 signify, in each case, O or S, R1 signifies H or alkyl with 1 to 10 carbon atoms, R2 signifies H or COOR7, R3 and R4 signify R8, R8-CH2-, p-R8- C6H4-, 3-hydroxypyrrolidine, 3-hydroxypiperidine, morpholino, isoindolin, 1,2,3,4-tetrahydroquinoline, 1-R9-1,2,3,4-tetrahydro-4-quinolyl, 1-R10-4-piperidyl or 1-pyrrile, R5 and R6, in each case, signify H, alkyl with 1 to 4 carbon atoms or Hal, R7, R9 and R10, in each case, signify H or alkyl with 1 to 10 carbon atoms, R8 means pyrrolidino, piperidino or homopiperidino and Hal represents F, Cl, Br or I, as well as their physiologically acid or base compatible salts, characterized in that a phenol, or thiophenol, of formula II **(See formula)** wherein Z1, R3 and R5 have the meanings indicated above, or a functional derivative capable of reaction of a compound thereof, is reacted with a compound of formula III **(See formula)** wherein X means OH, optionally esterified, Cl, Br or I and Z2, r1, r2, r4 and r6 have the indicated meanings, or because a compound of formula IV **(See formula)** wherein Y means tetramethylene, pentamethiene, hexamethylene, 2-hydroxytetramethylene, 2-hydroxypentamethylene, 3-oxa-pentamethylene or o-xylylene, X1 means Cl, Br, I, NH2 or an OH group, optionally esterified or ethereal and X2 means a bond, -CH2- or p-C6H4 and Z1, Z2, R1, R2 and R4 to R6 have the meanings indicated above, are treated with cyclizing agents, or because in a compound of formula V **(See formula)** wherein W stands for a COOH group, optionally functionally modified and Z1, Z2 and R2 to R6 have the meanings indicated above, the W residue is converted to the COOR1 residue by treatment with solvolizing, thermolyzing or ester-forming agents, or why a compound of formula VI **(See formula)** where H, Cl, Br, I, or SO3M means and M represents an equivalent to a metal atom and Z1, Z2, r1, R2 and R4 to R6 have the meanings indicated above, are reacted with a compound of formula VII R3 - X4 VII in which X4 means H, M or X and R3, M and X have the meanings indicated above, provided that the residues X3 and X4 are different and one of these residues means H or, if appropriate, M, and because in a given case, in a compound obtained from formula I, the residue R2 is transformed into another residue R2 and/or a compound obtained from formula I is transformed by treatment with acids or bases in its acid addition salts or metal salts or ammonia, physiologically compatible and/or a compound of formula I is liberated from one of its salts by treatment with a base or acid. (Machine-translation by Google Translate, not legally binding)
ES409727A 1971-12-18 1972-12-16 Carboxylic acid derivatives and processes for their p'eparation Expired ES409727A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2163056A DE2163056A1 (en) 1971-12-18 1971-12-18 CARBONIC ACID DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
ES409727A1 true ES409727A1 (en) 1976-03-16

Family

ID=5828500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES409727A Expired ES409727A1 (en) 1971-12-18 1972-12-16 Carboxylic acid derivatives and processes for their p'eparation

Country Status (18)

Country Link
JP (1) JPS4867269A (en)
AT (1) AT329055B (en)
AU (1) AU464750B2 (en)
BE (1) BE792853A (en)
BR (1) BR7208702D0 (en)
CA (1) CA980346A (en)
CS (1) CS167366B2 (en)
DD (1) DD105443A5 (en)
DE (1) DE2163056A1 (en)
ES (1) ES409727A1 (en)
FR (1) FR2163487B1 (en)
GB (1) GB1358609A (en)
HU (1) HU165098B (en)
IL (1) IL40855A (en)
NL (1) NL7217100A (en)
PL (1) PL79179B1 (en)
RO (1) RO62851A (en)
ZA (1) ZA728065B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3448105A (en) * 1966-06-07 1969-06-03 Sandoz Ag Basic esters of malonic acid
CH514581A (en) * 1967-02-21 1971-10-31 Sandoz Ag Process for the production of new acetic acid derivatives
CH526538A (en) * 1967-07-22 1972-08-15 Merck Patent Gmbh Process for the preparation of aminophenylacetic acid derivatives
DE2112272A1 (en) * 1971-03-15 1972-10-05 Merck Patent Gmbh Phenoxyacetic acid derivatives and process for their preparation

Also Published As

Publication number Publication date
AU464750B2 (en) 1975-08-20
DE2163056A1 (en) 1973-06-20
HU165098B (en) 1974-06-28
CA980346A (en) 1975-12-23
BR7208702D0 (en) 1973-09-20
CS167366B2 (en) 1976-04-29
DD105443A5 (en) 1974-04-20
PL79179B1 (en) 1975-06-30
AU5022772A (en) 1974-06-20
NL7217100A (en) 1973-06-20
RO62851A (en) 1978-01-15
BE792853A (en) 1973-06-15
FR2163487B1 (en) 1975-10-17
AT329055B (en) 1976-04-26
IL40855A (en) 1976-02-29
ATA1065772A (en) 1975-07-15
GB1358609A (en) 1974-07-03
JPS4867269A (en) 1973-09-13
IL40855A0 (en) 1973-01-30
FR2163487A1 (en) 1973-07-27
ZA728065B (en) 1973-07-25

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