ES404401A1 - Procedure for obtaining pharmaceutically acceptable salts from derivatives of aza-8 purinones-6. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of pharmaceutically acceptable salts of aza-8 purinone-6 derivatives, characterized in that an aza-8 purinone-6 derivative of general formula is reacted: ** (see formula) ** One of its isomers or one of its tautomeric forms, formula in which: r represents a phenyl or naphthyl radical unsubstituted or substituted by one or more halogen atoms, hydroxy, alkyl, phenylalkyl, alkyloxy, alkenyloxy, alkynyloxy, alkyloxyalkyloxy radicals, phenoxy, aralkoxy, alkylthio, hydroxyalkyl, nitro, aleanosulfonyl, alkanoyl, alkyloxycarbonyl, trifluoromethyl, methylenedioxy, amino, amino substituted by one or two alkyl, phenyl, alkanoyl, alkanesulfonyl, arenesulphonyl groups; a straight or branched alkenyl or alkynyl chain comprising from 2 to 6 carbon atoms; a cycloalkyl radical comprising from 3 to 8 carbon atoms; an alkyl radical comprising 2 to 10 carbon atoms, straight or branched; an alkyl radical comprising from 1 to 10 carbon atoms substituted by one or more halogen atoms, hydroxyl radicals, cycloalkyl comprising from 3 to 8 carbon atoms, straight or branched alkyloxy comprising from 6 carbon atoms, phenyl not substituted or substituted by one or more halogen atoms, straight or branched alkyl comprising from 1 to 6 carbon atoms, alkyloxy comprising from 1 to 6 carbon atoms, hydroxy, phenylalkoxy groups in which the alkoxy portions comprise from 1 to 6 carbon atoms, with a pharmaceutically acceptable base and then the formed product is isolated. (Machine-translation by Google Translate, not legally binding)