ES404400A1 - Procedure for the obtaining of derivatives of aza-8-purinonas-6. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining aza-8 purinones-6 derivatives, of general formula: **(See formula)** their isomers, tautomeric forms and the pharmaceutically acceptable salts derived therefrom; formula in which R represents a phenyl or naphthyl radical unsubstituted or substituted by one or more halogen atoms (preferably fluorine, chlorine, bromine), alkyl, phenylalkyl, alkyloxy, alkenyloxy, alkynyloxy, alkoxyalkyloxy, phenoxy, aralkoxy radicals (in particular phenylalkyloxy), alkylthio, nitro, alkanesulfonyl, alkanoyl, alkyloxycarbonyl, trifluoromethyl, methylenedioxy, amino substituted by one or two alkyl or phenyl groups; a straight or branched alkenyl or alkynyl chain comprising 2 to 6 carbon atoms; a cycloalkyl radical comprising 3 to 8 carbon atoms; an alkyl radical comprising 2 to 10 carbon atoms, straight or branched; a straight or branched alkyl radical comprising 1 to 10 carbon atoms substituted by one or more halogen atoms, cycloalkyl radicals comprising 3 to 8 carbon atoms, straight or branched alkyloxy comprising 1 to 6 carbon atoms, phenyl unsubstituted or substituted by one or more halogen atoms, straight or branched alkyl radicals comprising from 1 to 6 carbon atoms, straight or branched alkyloxy comprising from 1 to 6 carbon atoms, phenylalkoxy (for example benoyloxy) in the that the alkoxy portions comprise from 1 to 6 carbon atoms, characterized in that a compound of the general formula is reacted: **(See formula)** wherein R5 represents a hydroxy, alkyloxy, amino or dialkylamino radical with, when R represents an amino radical, a compound of the general formula: **(See formula)** and when R5 represents a hydroxy, alkyloxy, alkylamino, amino or dialkylamino radical, with a compound of the general formula: **(See formula)** isolating the obtained product; in the preceding formulas: R is defined as above, R represents a radical R whose carbon atom that is bonded in position 2 to the nucleus of azapurinone does not comprise a hydrogen atom, R1 represents an alkyl radical, preferably methyl or ethyl, R3 and R4 each represent a hydrogen atom or an alkyl radical comprising 1 to 6 carbon atoms, preferably methyl or ethyl, Z represents a halogen atom, preferably chlorine, Y- represents an anion such as chloride, borofluoride or fluorsulfonate, Xn- represents the anion of a strong acid such as hydrochloric acid, where n is the basicity of said acid. (Machine-translation by Google Translate, not legally binding)