ES402230A1 - Procedimiento para preparar nuevos 21-esteres de acido ni- trico que pertenecen a la serie del pregnano. - Google Patents
Procedimiento para preparar nuevos 21-esteres de acido ni- trico que pertenecen a la serie del pregnano.Info
- Publication number
- ES402230A1 ES402230A1 ES402230A ES402230A ES402230A1 ES 402230 A1 ES402230 A1 ES 402230A1 ES 402230 A ES402230 A ES 402230A ES 402230 A ES402230 A ES 402230A ES 402230 A1 ES402230 A1 ES 402230A1
- Authority
- ES
- Spain
- Prior art keywords
- nitric acid
- acid esters
- formula
- group
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 title 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003128 pregnanes Chemical class 0.000 abstract 2
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HURI429A HU164115B (env) | 1971-05-07 | 1971-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES402230A1 true ES402230A1 (es) | 1975-03-16 |
Family
ID=11000864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES402230A Expired ES402230A1 (es) | 1971-05-07 | 1972-04-22 | Procedimiento para preparar nuevos 21-esteres de acido ni- trico que pertenecen a la serie del pregnano. |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5330707B1 (env) |
| AT (1) | AT316767B (env) |
| AU (1) | AU469581B2 (env) |
| CA (1) | CA975755A (env) |
| CS (2) | CS171259B2 (env) |
| DD (1) | DD98668A5 (env) |
| DE (1) | DE2222491C3 (env) |
| ES (1) | ES402230A1 (env) |
| FR (1) | FR2143664A1 (env) |
| HU (1) | HU164115B (env) |
| NL (1) | NL7206134A (env) |
| PL (1) | PL75494B1 (env) |
| SE (2) | SE385590B (env) |
| SU (1) | SU493963A3 (env) |
| YU (1) | YU34701B (env) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707984A (en) * | 1995-12-08 | 1998-01-13 | G. D. Searle & Co. | Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs |
| US5792758A (en) * | 1995-12-08 | 1998-08-11 | G. D. Searle & Co. | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| ITMI20020148A1 (it) | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| US20100041633A1 (en) | 2007-02-05 | 2010-02-18 | Nicox S.A. | Nitric oxide releasing steroids |
| HUE027463T2 (en) | 2008-05-28 | 2016-09-28 | Reveragen Biopharma Inc | Non-hormonal steroid modulators of nf-kb for treatment of disease |
| US9198921B2 (en) | 2010-04-05 | 2015-12-01 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| CN102302501B (zh) * | 2010-06-07 | 2012-10-03 | 刘超 | 糖皮质激素硝基衍生物在制备利尿药物制剂中的应用 |
| US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
-
1971
- 1971-05-07 HU HURI429A patent/HU164115B/hu unknown
-
1972
- 1972-04-20 AT AT345872A patent/AT316767B/de not_active IP Right Cessation
- 1972-04-22 ES ES402230A patent/ES402230A1/es not_active Expired
- 1972-04-26 YU YU1117/72A patent/YU34701B/xx unknown
- 1972-04-28 DD DD162651A patent/DD98668A5/xx unknown
- 1972-05-01 AU AU41722/72A patent/AU469581B2/en not_active Expired
- 1972-05-04 JP JP4376772A patent/JPS5330707B1/ja active Pending
- 1972-05-04 FR FR7215938A patent/FR2143664A1/fr active Granted
- 1972-05-05 SU SU1783400A patent/SU493963A3/ru active
- 1972-05-05 SE SE7205915A patent/SE385590B/xx unknown
- 1972-05-05 NL NL7206134A patent/NL7206134A/xx not_active Application Discontinuation
- 1972-05-05 PL PL15518272A patent/PL75494B1/pl unknown
- 1972-05-05 CS CS2266*[A patent/CS171259B2/cs unknown
- 1972-05-05 CA CA141,366A patent/CA975755A/en not_active Expired
- 1972-05-05 CS CS3050A patent/CS171258B2/cs unknown
- 1972-05-08 DE DE2222491A patent/DE2222491C3/de not_active Expired
-
1975
- 1975-03-21 SE SE7503290A patent/SE7503290L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU34701B (en) | 1979-12-31 |
| YU111772A (en) | 1979-07-10 |
| DE2222491C3 (de) | 1978-05-03 |
| AU469581B2 (en) | 1976-02-19 |
| SE385590B (sv) | 1976-07-12 |
| CS171259B2 (env) | 1976-10-29 |
| CA975755A (en) | 1975-10-07 |
| FR2143664A1 (en) | 1973-02-09 |
| AT316767B (de) | 1974-07-25 |
| DE2222491B2 (de) | 1977-09-29 |
| SE7503290L (env) | 1975-03-21 |
| DE2222491A1 (de) | 1972-11-16 |
| AU4172272A (en) | 1973-11-08 |
| NL7206134A (env) | 1972-11-09 |
| SU493963A3 (ru) | 1975-11-28 |
| FR2143664B1 (env) | 1976-07-02 |
| JPS5330707B1 (env) | 1978-08-29 |
| PL75494B1 (env) | 1974-12-31 |
| DD98668A5 (env) | 1973-07-05 |
| CS171258B2 (env) | 1976-10-29 |
| HU164115B (env) | 1973-12-28 |
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