ES401616A1 - Procedure for the obtaining of 1,4-dihydropyridin-dicharboxylates asymmetrical. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of 1,4-dihydropyridin-dicharboxylates asymmetrical. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES401616A1
ES401616A1 ES401616A ES401616A ES401616A1 ES 401616 A1 ES401616 A1 ES 401616A1 ES 401616 A ES401616 A ES 401616A ES 401616 A ES401616 A ES 401616A ES 401616 A1 ES401616 A1 ES 401616A1
Authority
ES
Spain
Prior art keywords
formula
alkyl
indicated above
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES401616A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES401616A1 publication Critical patent/ES401616A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for obtaining asymmetric 1,4-dihydropyridicarboxylates, of general formula: **(See formula)** wherein R is a phenyl moiety, containing 1-3 equal or different substituents of the alkyl, alkoxy, halogen, nitro, cyano, azido, trifluoromethyl, carbalkoxy or SO-alkyl group (n = 0-2) or which means a naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, tenyl, furyl or pyrrile, optionally substituted by alkyl, alkoxy or halogen, and R1 and R3 which are the same or different mean hydrogen, phenyl a straight or branched chain alkyl moiety and R2 and R4 which are different from each other and signify a saturated or unsaturated straight, branched or cyclic hydrocarbon residue, which is interrupted by 1 or 2 oxygen atoms in the chain and/or substituted by a hydroxy group, characterized by that, characterized by that aldehydes of formula (II) RCHO (II) where R has the meaning indicated above, they are reacted with β-ketocarboxylates of formula (III) R1COCH2COOR2 (III) in which R1 and R2 have the meanings indicated above and enaminocarboxylates of formula (IV) **(See formula)** in which R3 and R4 have the meanings indicated above, in the presence of water or inert organic solvents at temperatures between 30 and 200ºC. (Machine-translation by Google Translate, not legally binding)
ES401616A 1971-04-10 1972-04-08 Procedure for the obtaining of 1,4-dihydropyridin-dicharboxylates asymmetrical. (Machine-translation by Google Translate, not legally binding) Expired ES401616A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712117573 DE2117573C3 (en) 1971-04-10 1971-04-10 Process for the preparation of asymmetrical 1,4-dihydropyridine-3,5dicarboxylic acid esters, and their use as medicaments

Publications (1)

Publication Number Publication Date
ES401616A1 true ES401616A1 (en) 1975-02-16

Family

ID=5804435

Family Applications (1)

Application Number Title Priority Date Filing Date
ES401616A Expired ES401616A1 (en) 1971-04-10 1972-04-08 Procedure for the obtaining of 1,4-dihydropyridin-dicharboxylates asymmetrical. (Machine-translation by Google Translate, not legally binding)

Country Status (19)

Country Link
JP (1) JPS5529990B1 (en)
AT (1) AT315178B (en)
BG (1) BG20105A3 (en)
CA (1) CA934758A (en)
CH (1) CH571492A5 (en)
CS (1) CS178407B2 (en)
DD (1) DD104520A5 (en)
DE (1) DE2117573C3 (en)
DK (1) DK134600C (en)
ES (1) ES401616A1 (en)
FI (1) FI55188C (en)
HU (1) HU163996B (en)
LU (1) LU65130A1 (en)
NL (1) NL170535C (en)
NO (1) NO133712C (en)
PL (1) PL83824B1 (en)
RO (1) RO61069A (en)
SE (1) SE371441B (en)
SU (1) SU421193A3 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320750A1 (en) * 1975-08-12 1977-03-11 Hexachimie 1,4-DIHYDRO PYRIDINES AND THEIR THERAPEUTIC APPLICATION
DE2650013C3 (en) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid isopropyl (2-propoxy-ethyl) ester, process for its preparation and medicinal products containing it
DE2815578C2 (en) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen New pharmaceutical use of nimodipine
SE429652B (en) * 1978-06-30 1983-09-19 Haessle Ab 2,6-dimethyl-4- (2,3-dichlorophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-ethyl ester
DE2841667A1 (en) * 1978-09-25 1980-04-10 Bayer Ag FLUORINE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
JPS58159490A (en) * 1982-02-23 1983-09-21 Nikken Kagaku Kk 1,4-dihydropyridne compound
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
JPS58185562A (en) * 1982-04-22 1983-10-29 Taisho Pharmaceut Co Ltd 1,4-dihydropyridine derivative
DE3222367A1 (en) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Use of 1,4-dihydropyridines in antiarteriosclerotics and preparation thereof
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
US4529733A (en) * 1983-04-06 1985-07-16 Merrell Dow Pharmaceuticals Inc. Antihypertensive 3-furoyl-1,4-dihydropyridines
US4607041A (en) * 1983-04-27 1986-08-19 Fisons Plc Antihypertensive 2-phenyl Hantzsch dihydropyridines
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
EP0311053A3 (en) * 1987-10-06 1991-05-08 Banyu Pharmaceutical Co., Ltd. Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
DE3741540A1 (en) * 1987-12-08 1989-06-22 Bayer Ag METHOD FOR PRODUCING UNSYMMETRIC DIHYDROPYRIDINES
DE59410255D1 (en) * 1993-12-10 2003-04-17 Bayer Ag Phenyl-substituted 1,4-dihydropyridines with cerebral activity
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (en) * 1996-08-23 1998-04-30 Lusochimica Spa DIHYDROPYRIDINE PREPARATION PROCESS
AU8430098A (en) * 1998-07-23 2000-02-14 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity

Also Published As

Publication number Publication date
NL170535B (en) 1982-06-16
PL83824B1 (en) 1976-02-28
AT315178B (en) 1974-05-10
NL7204695A (en) 1972-10-12
FI55188C (en) 1979-06-11
JPS5529990B1 (en) 1980-08-07
FI55188B (en) 1979-02-28
DK134600C (en) 1977-05-16
SU421193A3 (en) 1974-03-25
NL170535C (en) 1982-11-16
CA934758A (en) 1973-10-02
CH571492A5 (en) 1976-01-15
DE2117573B2 (en) 1977-12-01
RO61069A (en) 1976-11-15
CS178407B2 (en) 1977-09-15
NO133712C (en) 1976-06-16
DD104520A5 (en) 1974-03-12
NO133712B (en) 1976-03-08
HU163996B (en) 1973-12-28
BG20105A3 (en) 1975-10-30
DE2117573C3 (en) 1978-07-27
LU65130A1 (en) 1972-07-12
SE371441B (en) 1974-11-18
DK134600B (en) 1976-12-06
DE2117573A1 (en) 1972-10-19

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