ES400479A1 - Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES400479A1 ES400479A1 ES400479A ES400479A ES400479A1 ES 400479 A1 ES400479 A1 ES 400479A1 ES 400479 A ES400479 A ES 400479A ES 400479 A ES400479 A ES 400479A ES 400479 A1 ES400479 A1 ES 400479A1
- Authority
- ES
- Spain
- Prior art keywords
- diarrheic
- translation
- activity
- machine
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Process for obtaining piperidine derivatives with anti-diarrheic activity, of the general formula: ** (see formula) ** And the acid addition salts thereof, wherein (see formula) represents a fused, optionally substituted, monocyclic or polycyclic heterocyclic radical containing at least one carbonyl function adjacent to the nitrogen atom; characterized in that it comprises contacting a compound of general formula: ** (see formula) ** In which (see formula) is defined as above, and x represents a chlorine, bromine or iodine atom or a methanesulfonyloxy or toluenesulfonyloxy radical, with a compound of the general formula: ** (see formula) ** Wherein m is an active metal ion. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5968670A GB1356117A (en) | 1970-12-16 | 1970-12-16 | 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES400479A1 true ES400479A1 (en) | 1975-01-16 |
Family
ID=10484227
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES397911A Expired ES397911A1 (en) | 1970-12-16 | 1971-12-13 | Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES397912A Expired ES397912A1 (en) | 1970-12-16 | 1971-12-13 | Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES400478A Expired ES400478A1 (en) | 1970-12-16 | 1972-03-06 | Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding) |
| ES400479A Expired ES400479A1 (en) | 1970-12-16 | 1972-03-06 | Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES397911A Expired ES397911A1 (en) | 1970-12-16 | 1971-12-13 | Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES397912A Expired ES397912A1 (en) | 1970-12-16 | 1971-12-13 | Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES400478A Expired ES400478A1 (en) | 1970-12-16 | 1972-03-06 | Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding) |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5542996B1 (en) |
| CA (1) | CA918157A (en) |
| CY (1) | CY925A (en) |
| DK (2) | DK136037B (en) |
| ES (4) | ES397911A1 (en) |
| IE (2) | IE35890B1 (en) |
| SE (2) | SE370542B (en) |
| YU (2) | YU34991B (en) |
| ZA (2) | ZA718379B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6115962U (en) * | 1984-06-30 | 1986-01-30 | 儀介 野沢 | Pig tank |
-
1971
- 1971-12-09 CA CA129747A patent/CA918157A/en not_active Expired
- 1971-12-10 IE IE1571/71A patent/IE35890B1/en unknown
- 1971-12-10 IE IE1570/71A patent/IE35889B1/en unknown
- 1971-12-13 ES ES397911A patent/ES397911A1/en not_active Expired
- 1971-12-13 JP JP10093771A patent/JPS5542996B1/ja active Pending
- 1971-12-13 CY CY925A patent/CY925A/en unknown
- 1971-12-13 DK DK607571AA patent/DK136037B/en unknown
- 1971-12-13 ES ES397912A patent/ES397912A1/en not_active Expired
- 1971-12-13 DK DK607671AA patent/DK130966B/en unknown
- 1971-12-14 ZA ZA718379A patent/ZA718379B/en unknown
- 1971-12-14 SE SE7115978A patent/SE370542B/xx unknown
- 1971-12-14 ZA ZA718380A patent/ZA718380B/en unknown
- 1971-12-14 SE SE7115979A patent/SE370543B/xx unknown
-
1972
- 1972-03-06 ES ES400478A patent/ES400478A1/en not_active Expired
- 1972-03-06 ES ES400479A patent/ES400479A1/en not_active Expired
-
1978
- 1978-10-24 YU YU2487/78A patent/YU34991B/en unknown
- 1978-10-24 YU YU2486/78A patent/YU34990B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5542996B1 (en) | 1980-11-04 |
| SE370542B (en) | 1974-10-21 |
| DK136037B (en) | 1977-08-01 |
| ES397911A1 (en) | 1975-04-16 |
| CY925A (en) | 1977-12-23 |
| YU248778A (en) | 1979-12-31 |
| YU34991B (en) | 1980-06-30 |
| IE35889L (en) | 1972-06-16 |
| IE35889B1 (en) | 1976-06-23 |
| IE35890L (en) | 1972-06-16 |
| ZA718379B (en) | 1973-02-28 |
| ES397912A1 (en) | 1975-04-16 |
| DK130966B (en) | 1975-05-12 |
| YU248678A (en) | 1979-12-31 |
| ZA718380B (en) | 1973-02-28 |
| YU34990B (en) | 1980-06-30 |
| DK136037C (en) | 1978-01-02 |
| CA918157A (en) | 1973-01-02 |
| ES400478A1 (en) | 1975-01-01 |
| IE35890B1 (en) | 1976-06-23 |
| DK130966C (en) | 1975-10-06 |
| SE370543B (en) | 1974-10-21 |
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