ES397911A1 - Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES397911A1
ES397911A1 ES397911A ES397911A ES397911A1 ES 397911 A1 ES397911 A1 ES 397911A1 ES 397911 A ES397911 A ES 397911A ES 397911 A ES397911 A ES 397911A ES 397911 A1 ES397911 A1 ES 397911A1
Authority
ES
Spain
Prior art keywords
compounds
translation
machine
legally binding
google translate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES397911A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB5968670A external-priority patent/GB1356117A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES397911A1 publication Critical patent/ES397911A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds of the present invention possess valuable pharmacological properties. For example, said compounds constitute powerful antidiarrheal agents. Said compounds are also capable of counteracting the symptoms of withdrawal of substances that produce chronic intoxication by psychotropic drugs. Additionally, the compounds of this invention possess various analgesic, anti-protozoal, anti-bacterial, anti-algal, anti-fungal and anti-helminth activity. The antidiarrheal properties of the present compounds are specifically illustrated by the activity of the representative species constituting N- [1- (3-cyano-3,3-diphenylpropyl) -4-phenyl-piperidine-4-carbonyloxy] succeimide hydrochloride. And 3- [1- (3-cyano-3,3-diphenylpropyl) -4-phenylpiperidine-4-carbonyloxy] -3h-1,2,3-benzotriazin-4-one hydrochloride, in the following test procedures. (Machine-translation by Google Translate, not legally binding)
ES397911A 1970-12-16 1971-12-13 Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES397911A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5968670A GB1356117A (en) 1970-12-16 1970-12-16 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
ES397911A1 true ES397911A1 (en) 1975-04-16

Family

ID=10484227

Family Applications (4)

Application Number Title Priority Date Filing Date
ES397911A Expired ES397911A1 (en) 1970-12-16 1971-12-13 Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding)
ES397912A Expired ES397912A1 (en) 1970-12-16 1971-12-13 Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding)
ES400479A Expired ES400479A1 (en) 1970-12-16 1972-03-06 Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding)
ES400478A Expired ES400478A1 (en) 1970-12-16 1972-03-06 Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding)

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES397912A Expired ES397912A1 (en) 1970-12-16 1971-12-13 Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding)
ES400479A Expired ES400479A1 (en) 1970-12-16 1972-03-06 Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding)
ES400478A Expired ES400478A1 (en) 1970-12-16 1972-03-06 Procedure for the obtaining of piperidine derivatives with anti-diarrheic activity. (Machine-translation by Google Translate, not legally binding)

Country Status (9)

Country Link
JP (1) JPS5542996B1 (en)
CA (1) CA918157A (en)
CY (1) CY925A (en)
DK (2) DK130966B (en)
ES (4) ES397911A1 (en)
IE (2) IE35890B1 (en)
SE (2) SE370543B (en)
YU (2) YU34990B (en)
ZA (2) ZA718380B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6115962U (en) * 1984-06-30 1986-01-30 儀介 野沢 Pig tank

Also Published As

Publication number Publication date
SE370542B (en) 1974-10-21
DK130966C (en) 1975-10-06
DK130966B (en) 1975-05-12
IE35890B1 (en) 1976-06-23
IE35889L (en) 1972-06-16
DK136037C (en) 1978-01-02
CY925A (en) 1977-12-23
ES400479A1 (en) 1975-01-16
JPS5542996B1 (en) 1980-11-04
ES397912A1 (en) 1975-04-16
IE35889B1 (en) 1976-06-23
ES400478A1 (en) 1975-01-01
IE35890L (en) 1972-06-16
DK136037B (en) 1977-08-01
SE370543B (en) 1974-10-21
ZA718379B (en) 1973-02-28
CA918157A (en) 1973-01-02
YU248678A (en) 1979-12-31
YU248778A (en) 1979-12-31
YU34990B (en) 1980-06-30
YU34991B (en) 1980-06-30
ZA718380B (en) 1973-02-28

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