ES398131A1 - Bicyclic compounds and the manufacture thereof - Google Patents
Bicyclic compounds and the manufacture thereofInfo
- Publication number
- ES398131A1 ES398131A1 ES398131A ES398131A ES398131A1 ES 398131 A1 ES398131 A1 ES 398131A1 ES 398131 A ES398131 A ES 398131A ES 398131 A ES398131 A ES 398131A ES 398131 A1 ES398131 A1 ES 398131A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- carbon
- compound
- see formula
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of bicyclic compounds of the formula ** (See formula) ** where R1 is a primary alkyl group of 1 to 5 carbon atoms; R2 and R4 are each hydrogen or taken together form a carbon-carbon bond; R3 is a primary alkyl group of 1 to 8 carbon atoms or a cycloalkyl group of 3 to 8 carbon atoms; R5 is hydrogen or, provided that R2 and R4 form a carbon-carbon bond, it forms a carbon-carbon bond together with R9 R9 is OR6 or provided that R2 and R4, taken together, form a carbon-carbon bond, R5 and R9 taken together form a carbon-carbon bond; R6 is hydrogen, lower acyl, or aroyl; Z is (see formula) or a group of the formula ** (See formula) ** R7 is hydrogen, lower acyl, lower alkyl, arylalkyl or tetrahydropyran-2-yl; R8 is hydrogen or an aliphatic hydrocarbyl group and m is 1 or 2, which comprises reacting a compound of the formula ** (See formula) ** where R3 has the above significance and R12 is chlorine, bromine, iodine, hydroxyl, lower alkoxy, lower hydrocarbylamino or di- (lower hydrocarbyl) -amino, with a compound of the formula ** (See formula) ** where R1 and m have the above significance, and, if desired, convert the carbonyl group adjacent to the R1 substituent of the reaction product of the formula ** (See formula) ** in a group of the formula ** (See formula) ** where R7 and R8 have the above significance, and/or if desired, esterify the hydroxyl group of a compound of the formula ** (See formula) ** to form a compound of the formula ** (See formula) ** where R1, R3, Z and m have the above significance and R6'is lower acyl or aroyl, and/or, if desired, treating a compound of the formula ** (See formula) ** with a strong acid catalyst to produce a compound of the formula ** (See formula) ** where R1, R3, Z and m have the above significance, and, if desired, catalytically hydrogenate a compound of formula Ia'with a molar equivalent of hydrogen to produce a compound of formula ** (See formula) ** where R1, R3, R6, Z and m have the above significance. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10037270A | 1970-12-21 | 1970-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES398131A1 true ES398131A1 (en) | 1974-07-16 |
Family
ID=22279405
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398130A Expired ES398130A1 (en) | 1970-12-21 | 1971-12-20 | Bicyclic compounds and the manufacture thereof |
| ES398131A Expired ES398131A1 (en) | 1970-12-21 | 1971-12-20 | Bicyclic compounds and the manufacture thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398130A Expired ES398130A1 (en) | 1970-12-21 | 1971-12-20 | Bicyclic compounds and the manufacture thereof |
Country Status (16)
| Country | Link |
|---|---|
| AR (2) | AR194088A1 (en) |
| AT (2) | AT316519B (en) |
| AU (2) | AU3713171A (en) |
| BE (2) | BE776940A (en) |
| CA (1) | CA1000716A (en) |
| CH (3) | CH584706A5 (en) |
| DE (3) | DE2162801A1 (en) |
| ES (2) | ES398130A1 (en) |
| FR (3) | FR2120817A5 (en) |
| GB (3) | GB1317090A (en) |
| HU (2) | HU164613B (en) |
| IE (2) | IE35904B1 (en) |
| IL (3) | IL38281A (en) |
| NL (2) | NL7117469A (en) |
| PH (1) | PH9548A (en) |
| ZA (2) | ZA718280B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2050825A1 (en) * | 1990-09-24 | 1992-03-25 | Pamela M. Simpson | Method of making optically active alcohols |
-
1971
- 1971-12-01 IL IL38281A patent/IL38281A/en unknown
- 1971-12-10 CH CH1555474A patent/CH584706A5/xx not_active IP Right Cessation
- 1971-12-10 CH CH1805571A patent/CH584705A5/xx not_active IP Right Cessation
- 1971-12-10 ZA ZA718280A patent/ZA718280B/en unknown
- 1971-12-10 ZA ZA718281A patent/ZA718281B/en unknown
- 1971-12-10 CH CH1805471A patent/CH586662A5/xx not_active IP Right Cessation
- 1971-12-17 IE IE1599/71A patent/IE35904B1/en unknown
- 1971-12-17 DE DE19712162801 patent/DE2162801A1/en active Pending
- 1971-12-17 IL IL38391A patent/IL38391A/en unknown
- 1971-12-17 DE DE19712162803 patent/DE2162803A1/en active Pending
- 1971-12-17 IE IE1600/71A patent/IE35905B1/en unknown
- 1971-12-17 IL IL38392A patent/IL38392A/en unknown
- 1971-12-17 PH PH13118*UA patent/PH9548A/en unknown
- 1971-12-17 DE DE19712162800 patent/DE2162800A1/en active Pending
- 1971-12-20 ES ES398130A patent/ES398130A1/en not_active Expired
- 1971-12-20 AU AU37131/71A patent/AU3713171A/en not_active Expired
- 1971-12-20 AT AT1092171A patent/AT316519B/en not_active IP Right Cessation
- 1971-12-20 GB GB5901871A patent/GB1317090A/en not_active Expired
- 1971-12-20 AT AT583173A patent/AT316520B/en not_active IP Right Cessation
- 1971-12-20 CA CA130,509A patent/CA1000716A/en not_active Expired
- 1971-12-20 NL NL7117469A patent/NL7117469A/xx unknown
- 1971-12-20 AU AU37132/71A patent/AU456833B2/en not_active Expired
- 1971-12-20 BE BE776940A patent/BE776940A/en unknown
- 1971-12-20 NL NL7117495A patent/NL7117495A/xx unknown
- 1971-12-20 BE BE776939A patent/BE776939A/en unknown
- 1971-12-20 ES ES398131A patent/ES398131A1/en not_active Expired
- 1971-12-20 GB GB5901771A patent/GB1337790A/en not_active Expired
- 1971-12-20 GB GB5901671A patent/GB1319010A/en not_active Expired
- 1971-12-21 HU HUHO1439A patent/HU164613B/hu unknown
- 1971-12-21 AR AR239722A patent/AR194088A1/en active
- 1971-12-21 FR FR7145928A patent/FR2120817A5/fr not_active Expired
- 1971-12-21 FR FR7145930A patent/FR2118979B1/fr not_active Expired
- 1971-12-21 AR AR239723A patent/AR192603A1/en active
- 1971-12-21 HU HUHO1438A patent/HU164759B/hu unknown
- 1971-12-21 FR FR7145929A patent/FR2120818A5/fr not_active Expired
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