ES393521A1 - Procedure for the preparation of derivatives of 1,3,4,5-tetrahidro - 2H - 1,4-benzodiazepin-2-ona. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of derivatives of 1,3,4,5-tetrahidro - 2H - 1,4-benzodiazepin-2-ona. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES393521A1
ES393521A1 ES393521A ES393521A ES393521A1 ES 393521 A1 ES393521 A1 ES 393521A1 ES 393521 A ES393521 A ES 393521A ES 393521 A ES393521 A ES 393521A ES 393521 A1 ES393521 A1 ES 393521A1
Authority
ES
Spain
Prior art keywords
derivatives
benzodiazepin
translation
preparation
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES393521A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES393521A1 publication Critical patent/ES393521A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Process for the preparation of 1,3,4,5-tetrahydra-2H-l, 4-benzodiazepin-2-one derivatives of the general formula i ** (see formula) ** Wherein r means a hydrogen atom or an alkyl group of 1 to 5 carbon atoms and x means a hydrogen or halogen atom or an amino group, characterized in that N-acylated 2-amino-benzophenone derivatives are catalytically hydrogenated. The general formula ii ** (see formula) ** Wherein x'means a hydrogen or halogen atom, or a nitro or amino group, y means a protective group capable of being separated by catalytic hydrogenation and r has the above meanings. (Machine-translation by Google Translate, not legally binding)
ES393521A 1970-07-30 1971-07-22 Procedure for the preparation of derivatives of 1,3,4,5-tetrahidro - 2H - 1,4-benzodiazepin-2-ona. (Machine-translation by Google Translate, not legally binding) Expired ES393521A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI000403 1970-07-30

Publications (1)

Publication Number Publication Date
ES393521A1 true ES393521A1 (en) 1973-08-16

Family

ID=11000846

Family Applications (1)

Application Number Title Priority Date Filing Date
ES393521A Expired ES393521A1 (en) 1970-07-30 1971-07-22 Procedure for the preparation of derivatives of 1,3,4,5-tetrahidro - 2H - 1,4-benzodiazepin-2-ona. (Machine-translation by Google Translate, not legally binding)

Country Status (10)

Country Link
JP (1) JPS5432792B1 (en)
AT (1) AT311356B (en)
CH (1) CH558370A (en)
CS (1) CS171708B2 (en)
DK (1) DK141604B (en)
ES (1) ES393521A1 (en)
NL (1) NL7110356A (en)
PL (1) PL70872B1 (en)
SE (1) SE385888B (en)
SU (1) SU461503A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187262B (en) * 1979-08-16 1985-12-28 Richter Gedeon Vegyeszet Process for preparing new tetrahydro-1,4-benzodiazepin-2-ones

Also Published As

Publication number Publication date
AT311356B (en) 1973-11-12
DK141604B (en) 1980-05-05
CH558370A (en) 1975-01-31
DK141604C (en) 1980-10-06
SU461503A3 (en) 1975-02-25
PL70872B1 (en) 1974-04-30
CS171708B2 (en) 1976-10-29
NL7110356A (en) 1972-02-01
JPS5432792B1 (en) 1979-10-16
SE385888B (en) 1976-07-26

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