ES391009A1 - Substituted alkanol-thioalkyl-amines - Google Patents
Substituted alkanol-thioalkyl-aminesInfo
- Publication number
- ES391009A1 ES391009A1 ES391009A ES391009A ES391009A1 ES 391009 A1 ES391009 A1 ES 391009A1 ES 391009 A ES391009 A ES 391009A ES 391009 A ES391009 A ES 391009A ES 391009 A1 ES391009 A1 ES 391009A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- hydroxyl
- see formula
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Details Of Garments (AREA)
Abstract
Method for preparing compounds having the general formula: ** (See formula) ** (where Y1 and/or Y2 are a hydrogen atom, or one or more hydroxyl groups in the para position of the benzene rings, relative to the aliphatic chain that binds them, which hydroxyl can be free or etherified, such as with benzyl alcohol, or esterified, for example with lower aliphatic acids such as acetic acid, or with benzoic acid; R1 is a hydroxyalkylene group having 2 to 6 carbon atoms (such as hydroxyethylene, hydroxypropylene, and hydroxybutylene, where the hydroxyl group is bonded to a carbon atom other than that to which the nitrogen atom is bonded); R2 is an alcoholic group having 2 to 6 carbon atoms, such as ethylene, n-propylene or isopropylene), and salts thereof, characterized by reacting an amine chosen from among the following: ** (See formula) ** with a halogenated compound chosen respectively from the following: ** (See formula) ** (where R'1 is a hydroxyalkylene group having 2 to 6 carbon atoms, (such as hydroxyethylene, hydroxypropylene, or hydroxybutylene) or a ketoalkylene group (such as ketoethylene, ketopropylene, or ketobutylene), where the oxygen of the -OH group and CO, respectively, if any, is attached to a different carbon atom than that to which the nitrogen atom is attached; X is a halogen such as chlorine, bromine, iodine, preferably bromine or iodine; and R2 is as mentioned before); working in solvents (preferably isopropanol) in the presence of an acid scavenger, at a temperature that varies between 30 and 150ºC, preferably at 80ºC, at atmospheric pressure, for a total time of 3 to 6 hours, preferably 4 hours, obtaining a precipitate from the acid scavenger halide, which is separated by filtration, and a solution from which the expected base, or salt thereof, is isolated in a known manner; and when a ketone group is present in R1, it is reduced to a hydroxyl group by a known method. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT345470 | 1970-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES391009A1 true ES391009A1 (en) | 1973-06-16 |
Family
ID=11107661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391009A Expired ES391009A1 (en) | 1970-05-18 | 1971-05-10 | Substituted alkanol-thioalkyl-amines |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT308720B (en) |
| BE (1) | BE767045A (en) |
| CA (1) | CA993453A (en) |
| CH (1) | CH570371A5 (en) |
| DE (1) | DE2122435A1 (en) |
| ES (1) | ES391009A1 (en) |
| FR (1) | FR2100667B1 (en) |
| GB (1) | GB1283505A (en) |
| NL (1) | NL7011409A (en) |
| NO (1) | NO132636C (en) |
| SE (1) | SE378810B (en) |
| ZA (1) | ZA712725B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3119126A1 (en) | 2021-01-25 | 2022-07-29 | Psa Automobiles Sa | DEVICE FOR MAINTAINING AT LEAST ONE ELECTRICAL HARNESS CLOSE TO A BATTERY BOX |
-
1970
- 1970-07-31 NL NL7011409A patent/NL7011409A/xx unknown
-
1971
- 1971-04-27 ZA ZA712725A patent/ZA712725B/en unknown
- 1971-05-03 GB GB02793/71A patent/GB1283505A/en not_active Expired
- 1971-05-05 CH CH663471A patent/CH570371A5/xx not_active IP Right Cessation
- 1971-05-06 DE DE19712122435 patent/DE2122435A1/en active Pending
- 1971-05-10 ES ES391009A patent/ES391009A1/en not_active Expired
- 1971-05-11 SE SE7106059A patent/SE378810B/xx unknown
- 1971-05-12 BE BE767045A patent/BE767045A/en unknown
- 1971-05-13 NO NO711809A patent/NO132636C/no unknown
- 1971-05-18 CA CA113,293A patent/CA993453A/en not_active Expired
- 1971-05-18 FR FR7117950A patent/FR2100667B1/fr not_active Expired
- 1971-05-18 AT AT430171A patent/AT308720B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA993453A (en) | 1976-07-20 |
| BE767045A (en) | 1971-10-01 |
| NO132636C (en) | 1975-12-10 |
| CH570371A5 (en) | 1975-12-15 |
| NO132636B (en) | 1975-09-01 |
| SE378810B (en) | 1975-09-15 |
| FR2100667A1 (en) | 1972-03-24 |
| NL7011409A (en) | 1971-11-22 |
| ZA712725B (en) | 1972-03-29 |
| GB1283505A (en) | 1972-07-26 |
| DE2122435A1 (en) | 1971-12-09 |
| AT308720B (en) | 1973-07-25 |
| FR2100667B1 (en) | 1974-08-30 |
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