ES406929A1 - Analgesic derivatives of the series of sulphur-containing arylamines - Google Patents
Analgesic derivatives of the series of sulphur-containing arylaminesInfo
- Publication number
- ES406929A1 ES406929A1 ES406929A ES406929A ES406929A1 ES 406929 A1 ES406929 A1 ES 406929A1 ES 406929 A ES406929 A ES 406929A ES 406929 A ES406929 A ES 406929A ES 406929 A1 ES406929 A1 ES 406929A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- nr1r2
- group
- aryl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Procedure for obtaining amine aryl-mercaptans S-oxide compounds, useful as analgesic substances, which respond to the general formula: Ar - SOx - A - NR1R2 (I) where x is an integer having a value from 1 to 2; A is a C2-C4 alkylene group; NR1R2 represents a secondary, tertiary and N-heterocyclic amino group with 5 to 7 vertices that can comprise a second heteroatom chosen from among the sulfur, oxygen and nitrogen atoms, and that can comprise at least one substituent chosen mainly from among the alkyl groups in C1-C5 hydroxyalkyl containing from 1 to 5 carbon atoms and phenyl; Ar represents an aryl group, an aryl group mainly substituted by at least one halogen atom, and a 2-benzimidazolyl group, and their addition salts with acids, characterized in that it comprises reacting, in arbitrary sequence, a) in acid acetic, at a temperature greater than or equal to 20ºC, hydrogen peroxide on a chlorinated derivative of an arylthioalkyl of formula: Ar - S - A - Cl (II) wherein Ar and A are defined as above, and b) condensing an amine of formula: HNR1R2 (III) wherein NR1R2 is defined as above, and c) transforming, if appropriate, the compound of formula I, thus obtained, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4424171A GB1371650A (en) | 1971-09-22 | 1971-09-22 | Analgesic derivatives of the series of sulphur-containing arylamines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES406929A1 true ES406929A1 (en) | 1976-02-01 |
Family
ID=10432415
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES406929A Expired ES406929A1 (en) | 1971-09-22 | 1972-09-22 | Analgesic derivatives of the series of sulphur-containing arylamines |
ES436363A Expired ES436363A1 (en) | 1971-09-22 | 1975-04-07 | Analgesic derivatives of the series of sulphur-containing arylamines |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES436363A Expired ES436363A1 (en) | 1971-09-22 | 1975-04-07 | Analgesic derivatives of the series of sulphur-containing arylamines |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS5755718B2 (en) |
AR (2) | AR202378A1 (en) |
AU (1) | AU472048B2 (en) |
BE (1) | BE788805A (en) |
CA (1) | CA996129A (en) |
CH (2) | CH565757A5 (en) |
DE (1) | DE2246429C3 (en) |
ES (2) | ES406929A1 (en) |
FR (1) | FR2154528B1 (en) |
GB (1) | GB1371650A (en) |
IL (1) | IL40393A0 (en) |
IN (1) | IN137842B (en) |
NL (1) | NL7212829A (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2285867A1 (en) * | 1974-09-30 | 1976-04-23 | Lafon Labor | DIPHENYLSULFOXIDE DERIVATIVES |
US4155907A (en) * | 1976-08-16 | 1979-05-22 | The Dow Chemical Company | Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines |
FR2432316A1 (en) * | 1978-08-02 | 1980-02-29 | Choay Sa | NOVEL MEDICINAL PRODUCTS CONTAINING, AS ACTIVE SUBSTANCE, BENZENESULFONE-LIKE COMPOUNDS, NOVEL SUCH COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
JPS5739044Y2 (en) * | 1978-08-21 | 1982-08-27 | ||
FR2447909A1 (en) * | 1979-01-31 | 1980-08-29 | Choay Sa | Alkyl phenyl sulphone(s) - used as antilipaemic agents, act on the central nervous system, and affect mitosis |
JPS5964720U (en) * | 1982-10-22 | 1984-04-28 | 日本軽金属株式会社 | liquid container |
EP0174717B1 (en) * | 1984-07-06 | 1992-01-22 | FISONS plc | Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors |
AR243167A1 (en) | 1985-08-24 | 1993-07-30 | Hoechst Ag | Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors |
JP2933739B2 (en) * | 1990-04-09 | 1999-08-16 | 明治製菓株式会社 | Thiazole or imidazole derivatives and anti-ulcer agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD70880A (en) * | ||||
FR2100668A1 (en) * | 1971-05-19 | 1972-03-24 | Sumitomo Chemical Co | Pharmacol-active heterocyclic cpds |
JPS4946312A (en) * | 1972-09-05 | 1974-05-02 |
-
0
- BE BE788805D patent/BE788805A/en not_active IP Right Cessation
-
1971
- 1971-09-22 GB GB4424171A patent/GB1371650A/en not_active Expired
-
1972
- 1972-09-18 FR FR7233005A patent/FR2154528B1/fr not_active Expired
- 1972-09-20 CA CA152,193A patent/CA996129A/en not_active Expired
- 1972-09-20 IL IL40393A patent/IL40393A0/en unknown
- 1972-09-21 CH CH111274A patent/CH565757A5/xx not_active IP Right Cessation
- 1972-09-21 DE DE2246429A patent/DE2246429C3/en not_active Expired
- 1972-09-21 CH CH1382272A patent/CH566308A5/xx not_active IP Right Cessation
- 1972-09-22 NL NL7212829A patent/NL7212829A/xx not_active Application Discontinuation
- 1972-09-22 AU AU46984/72A patent/AU472048B2/en not_active Expired
- 1972-09-22 IN IN1482/72A patent/IN137842B/en unknown
- 1972-09-22 ES ES406929A patent/ES406929A1/en not_active Expired
- 1972-09-22 JP JP47094643A patent/JPS5755718B2/ja not_active Expired
- 1972-09-22 AR AR244227A patent/AR202378A1/en active
-
1973
- 1973-05-31 AR AR248332A patent/AR198415A1/en active
-
1975
- 1975-04-07 ES ES436363A patent/ES436363A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2154528A1 (en) | 1973-05-11 |
AU4698472A (en) | 1974-03-28 |
CA996129A (en) | 1976-08-31 |
JPS4836147A (en) | 1973-05-28 |
CH566308A5 (en) | 1975-09-15 |
AU472048B2 (en) | 1976-05-13 |
IL40393A0 (en) | 1972-11-28 |
IN137842B (en) | 1975-09-27 |
AR198415A1 (en) | 1974-06-21 |
GB1371650A (en) | 1974-10-23 |
DE2246429B2 (en) | 1981-07-02 |
DE2246429A1 (en) | 1973-03-29 |
DE2246429C3 (en) | 1982-05-19 |
FR2154528B1 (en) | 1975-10-17 |
ES436363A1 (en) | 1977-01-01 |
BE788805A (en) | 1973-01-02 |
JPS5755718B2 (en) | 1982-11-25 |
CH565757A5 (en) | 1975-08-29 |
NL7212829A (en) | 1973-03-26 |
AR202378A1 (en) | 1975-06-06 |
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