ES387088A1 - Procedure for the obtaining of guanidines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of guanidines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES387088A1
ES387088A1 ES387088A ES387088A ES387088A1 ES 387088 A1 ES387088 A1 ES 387088A1 ES 387088 A ES387088 A ES 387088A ES 387088 A ES387088 A ES 387088A ES 387088 A1 ES387088 A1 ES 387088A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
guanidines
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES387088A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES387088A1 publication Critical patent/ES387088A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Procedure for obtaining guanidines, of formula: **(See formula)** wherein A is such that it forms with the carbon and nitrogen atoms shown an imidazole, pyrazole, thiazole or 1,2,4-triazole ring; X is hydrogen, lower alkyl, lower alkylthio, or amino; b is at least 1; n is 2-5; R2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, aryl, or aralkyl; R3 is hydrogen, methyl, aralkyl, or amino; R2 and R3 can together form a 5-membered ring with adjacent carbon and nitrogen atoms, provided that when A is such that it forms an imidazole ring with the aforementioned carbon and nitrogen atoms, R2 and R3 cannot be both hydrogen, characterized in that an amine of formula: **(See formula)** Where A, X, b and n are defined as above, it is reacted with an S-methylisothiourea of general formula: **(See formula)** in which R2 and R3 have the meaning indicated above. (Machine-translation by Google Translate, not legally binding)
ES387088A 1969-10-29 1971-01-08 Procedure for the obtaining of guanidines. (Machine-translation by Google Translate, not legally binding) Expired ES387088A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5289169 1969-10-29

Publications (1)

Publication Number Publication Date
ES387088A1 true ES387088A1 (en) 1973-06-16

Family

ID=10465723

Family Applications (2)

Application Number Title Priority Date Filing Date
ES385015A Expired ES385015A1 (en) 1969-10-29 1970-10-29 Procedure for the obtaining of isotioureas. (Machine-translation by Google Translate, not legally binding)
ES387088A Expired ES387088A1 (en) 1969-10-29 1971-01-08 Procedure for the obtaining of guanidines. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES385015A Expired ES385015A1 (en) 1969-10-29 1970-10-29 Procedure for the obtaining of isotioureas. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
JP (1) JPS4946307B1 (en)
DK (1) DK140938B (en)
ES (2) ES385015A1 (en)
FI (1) FI56001C (en)
IE (1) IE34882B1 (en)
IL (1) IL35518A (en)
NO (1) NO133197C (en)
PH (1) PH10563A (en)
SE (1) SE376613B (en)
SU (2) SU393828A3 (en)
ZA (1) ZA707151B (en)

Also Published As

Publication number Publication date
DK140938B (en) 1979-12-10
NO133197C (en) 1976-03-24
JPS4946307B1 (en) 1974-12-09
DK140938C (en) 1980-05-19
NO133197B (en) 1975-12-15
SU419026A3 (en) 1974-03-05
PH10563A (en) 1977-06-28
IE34882B1 (en) 1975-09-17
IE34882L (en) 1971-04-29
SU393828A3 (en) 1973-08-10
ES385015A1 (en) 1973-03-16
FI56001B (en) 1979-07-31
IL35518A (en) 1978-07-31
SE376613B (en) 1975-06-02
ZA707151B (en) 1971-07-28
IL35518A0 (en) 1970-12-24
FI56001C (en) 1979-11-12

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