ES386409A1 - Un procedimiento para la preparacion de 5-azaespiro (2,4) heptano-4,6-dionas. - Google Patents
Un procedimiento para la preparacion de 5-azaespiro (2,4) heptano-4,6-dionas.Info
- Publication number
- ES386409A1 ES386409A1 ES386409A ES386409A ES386409A1 ES 386409 A1 ES386409 A1 ES 386409A1 ES 386409 A ES386409 A ES 386409A ES 386409 A ES386409 A ES 386409A ES 386409 A1 ES386409 A1 ES 386409A1
- Authority
- ES
- Spain
- Prior art keywords
- heptane
- halogenophenyl
- trifluoromethylphenyl
- phenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 3
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- -1 trifluoromethylphenyl Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- JDFLTHIFPLPFRC-UHFFFAOYSA-N 1-(2-amino-2-oxoethyl)cyclopropane-1-carboxylic acid Chemical compound C(N)(=O)CC1(CC1)C(=O)O JDFLTHIFPLPFRC-UHFFFAOYSA-N 0.000 abstract 1
- TYHRCGALWHXYOO-UHFFFAOYSA-N 1-(carboxymethyl)cyclopropane-1-carboxylic acid Chemical compound OC(=O)CC1(C(O)=O)CC1 TYHRCGALWHXYOO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- VDFCBOUZRVZUPJ-UHFFFAOYSA-N 5-azaspiro[2.4]heptane-4,6-dione Chemical class O=C1NC(=O)CC11CC1 VDFCBOUZRVZUPJ-UHFFFAOYSA-N 0.000 abstract 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical class C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical group 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- ILPNRWUGFSPGAA-UHFFFAOYSA-N heptane-2,4-dione Chemical compound CCCC(=O)CC(C)=O ILPNRWUGFSPGAA-UHFFFAOYSA-N 0.000 abstract 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical compound OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590470A | 1970-01-26 | 1970-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES386409A1 true ES386409A1 (es) | 1973-12-01 |
Family
ID=21718290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES386409A Expired ES386409A1 (es) | 1970-01-26 | 1970-12-12 | Un procedimiento para la preparacion de 5-azaespiro (2,4) heptano-4,6-dionas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3654306A (OSRAM) |
| AU (1) | AU2455471A (OSRAM) |
| CA (1) | CA942753A (OSRAM) |
| CH (1) | CH547798A (OSRAM) |
| DE (1) | DE2103576A1 (OSRAM) |
| ES (1) | ES386409A1 (OSRAM) |
| FR (1) | FR2081459B1 (OSRAM) |
| GB (1) | GB1307341A (OSRAM) |
| ZA (1) | ZA71471B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5398959A (en) * | 1977-02-07 | 1978-08-29 | Sumitomo Chem Co Ltd | Cycloalkanespiro-3- 1-(3,5-dihalogenophenyl) pyrrolidine-2,5-dione process for their preparation and nonmedical fungicides containing the same as active constituents |
| FR2476075A1 (fr) * | 1980-02-18 | 1981-08-21 | Rhone Poulenc Agrochimie | Nouveaux derives de l'acide methylene-2 succinamique, leur preparation et les compositions regulatrices de la croissance des plantes les contenant |
| EP1289960A2 (en) * | 2000-06-15 | 2003-03-12 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists |
| US20040043988A1 (en) * | 2001-06-15 | 2004-03-04 | Khanna Ish Kurmar | Cycloalkyl alkanoic acids as intergrin receptor antagonists |
| WO2010043721A1 (en) | 2008-10-17 | 2010-04-22 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| KR101736218B1 (ko) | 2009-09-25 | 2017-05-16 | 오리존 지노믹스 에스.에이. | 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도 |
| WO2011042217A1 (en) | 2009-10-09 | 2011-04-14 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| WO2011106106A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
| WO2011106105A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
| JP5868948B2 (ja) | 2010-04-19 | 2016-02-24 | オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． | リジン特異的脱メチル化酵素１阻害薬およびその使用 |
| EP3375775A1 (en) | 2010-07-29 | 2018-09-19 | Oryzon Genomics, S.A. | Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use |
| EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712315B1 (en) | 2011-02-08 | 2021-11-24 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| IL264982B (en) | 2011-10-20 | 2022-08-01 | Oryzon Genomics Sa | Hetero(aryl)cyclopropylamine compounds as lsd1 inhibitors |
| US9487512B2 (en) | 2011-10-20 | 2016-11-08 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
-
1970
- 1970-01-26 US US5904A patent/US3654306A/en not_active Expired - Lifetime
- 1970-12-12 ES ES386409A patent/ES386409A1/es not_active Expired
-
1971
- 1971-01-12 GB GB149771A patent/GB1307341A/en not_active Expired
- 1971-01-19 CA CA103,115A patent/CA942753A/en not_active Expired
- 1971-01-21 AU AU24554/71A patent/AU2455471A/en not_active Expired
- 1971-01-25 CH CH107871A patent/CH547798A/fr not_active IP Right Cessation
- 1971-01-25 FR FR717102365A patent/FR2081459B1/fr not_active Expired
- 1971-01-25 ZA ZA710471A patent/ZA71471B/xx unknown
- 1971-01-26 DE DE19712103576 patent/DE2103576A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2455471A (en) | 1972-07-27 |
| FR2081459B1 (OSRAM) | 1974-02-15 |
| CH547798A (fr) | 1974-04-11 |
| CA942753A (en) | 1974-02-26 |
| US3654306A (en) | 1972-04-04 |
| ZA71471B (en) | 1971-11-24 |
| DE2103576A1 (de) | 1971-08-26 |
| FR2081459A1 (OSRAM) | 1971-12-03 |
| GB1307341A (en) | 1973-02-21 |
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