ES379706A1 - Procedure for the obtaining of quinazoline-2 (ih) -tiona derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining quinozoline-2 (1H) -thione derivatives, of formula Ia. **(See formula)** where R means a hydrogen, fluorine, chlorine or bromine atom, an alkyl radical of 1 to 5 carbon atoms, an alkoxy or alkylthio radical of 1 to 4 carbon atoms or a nitro, trifluomethyl or dialkyl (C1-14) group, Not me, n represents 1 or 2, with the proviso that when n is 2, substituents R which may be the same or different, mean a hydrogen, fluorine, chlorine or bromine atom, an alkyl radical of 1 to 5 carbon atoms or a alkoxy radical of 1 to 4 carbon atoms, R1 means an alkyl radical of 1 to 5 carbon atoms or an allyl or propargyl radical, R2 means a phenyl radical or a substituted phenyl radical of formula II, **(See formula)** wherein Y means a fluorine, chlorine or bromine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms or a trifluoromethyl group, and Y1 represents a hydrogen, fluorine, chlorine or bromine atom, an alkyl radical of 1 to 4 carbon atoms or an alkoxy radical of 1 to 4 carbon atoms; characterized in that a compound of formula IV is cyclized, **(See formula)** wherein R, R1, R2 and n have the meanings indicated above, subjecting it to the action of an acid chloride or bromide and an isothiocyanate of formula V, MN = C = S wherein M is an alkali or alkaline earth metal cation or ammonium cation, or to the action of the product of the reaction of an acid chloride or bromide and an isothiocyanate of formula V indicated above; preferably at a temperature of 10-80ºC, and appropriately in an organic solvent that is inert under the reaction conditions. (Machine-translation by Google Translate, not legally binding)