ES379156A1 - Quinazoline derivatives - Google Patents
Quinazoline derivativesInfo
- Publication number
- ES379156A1 ES379156A1 ES379156A ES379156A ES379156A1 ES 379156 A1 ES379156 A1 ES 379156A1 ES 379156 A ES379156 A ES 379156A ES 379156 A ES379156 A ES 379156A ES 379156 A1 ES379156 A1 ES 379156A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- radical
- formula
- fluorine
- alkyl radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/02—Viewing or reading apparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedure for obtaining quinazoline derivatives, of formula Id, **(See formula)** where R'''means a hydrogen, fluorine, chlorine or bromine atom, an alkyl radical of 1 to 5 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms, an alkylthio radical of 1 to 4 carbon atoms, or a nitro or trifluoromethyl group, n is 1 or 2, provided that when n is 2, each of the radicals R''', which may be the same or different, means a hydrogen, fluorine, or chlorine atom or bromine, an alkyl radical of 1 to 5 carbon atoms, or an alkoxy radical of 1 to 4 carbon atoms, R1 means an alkyl radical, of 1 to 5 carbon atoms, or an allyl or propargyl radical, R2 means a phenyl radical or a substituted phenyl radical of the formula **(See formula)** where Y means a fluorine, chlorine or bromine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms or a trifluoromethyl group, and Y1 means a hydrogen, fluorine, chlorine atom or bromine, an alkyl radical of 1 to 4 carbon atoms or an alkoxy radical of 1 to 4 carbon atoms, characterized in that a compound of formula V is hydrolyzed at a temperature of 10º to 150ºC, **(See formula)** where R''', R1, R2 and n have the meanings indicated above, preferably with an alkali metal hydroxide, conveniently at a temperature of 80º to 120ºC, and preferably in a solvent medium comprising water and a non-mixable organic solvent with water that is inert under the reaction conditions. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74180768A | 1968-07-01 | 1968-07-01 | |
| US74180668A | 1968-07-01 | 1968-07-01 | |
| US78725268A | 1968-12-26 | 1968-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES379156A1 true ES379156A1 (en) | 1973-02-01 |
Family
ID=27419278
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES368946A Expired ES368946A1 (en) | 1968-07-01 | 1969-06-30 | Quinazoline derivatives |
| ES379155A Expired ES379155A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379160A Expired ES379160A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379159A Expired ES379159A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379157A Expired ES379157A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379154A Expired ES379154A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379158A Expired ES379158A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379156A Expired ES379156A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES381047A Expired ES381047A1 (en) | 1968-07-01 | 1970-06-23 | Quinazoline derivatives |
| ES381048A Expired ES381048A1 (en) | 1968-07-01 | 1970-06-29 | Quinazoline derivatives |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES368946A Expired ES368946A1 (en) | 1968-07-01 | 1969-06-30 | Quinazoline derivatives |
| ES379155A Expired ES379155A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379160A Expired ES379160A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379159A Expired ES379159A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379157A Expired ES379157A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379154A Expired ES379154A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
| ES379158A Expired ES379158A1 (en) | 1968-07-01 | 1970-04-29 | Quinazoline derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES381047A Expired ES381047A1 (en) | 1968-07-01 | 1970-06-23 | Quinazoline derivatives |
| ES381048A Expired ES381048A1 (en) | 1968-07-01 | 1970-06-29 | Quinazoline derivatives |
Country Status (2)
| Country | Link |
|---|---|
| ES (10) | ES368946A1 (en) |
| GB (1) | GB1280551A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490374A (en) * | 1982-09-30 | 1984-12-25 | Ortho Pharmaceutical Corporation | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
| DE4442138A1 (en) * | 1994-11-26 | 1996-05-30 | Basf Ag | Process for the preparation of benzophenone imine |
-
1969
- 1969-06-13 GB GB3024669A patent/GB1280551A/en not_active Expired
- 1969-06-30 ES ES368946A patent/ES368946A1/en not_active Expired
-
1970
- 1970-04-29 ES ES379155A patent/ES379155A1/en not_active Expired
- 1970-04-29 ES ES379160A patent/ES379160A1/en not_active Expired
- 1970-04-29 ES ES379159A patent/ES379159A1/en not_active Expired
- 1970-04-29 ES ES379157A patent/ES379157A1/en not_active Expired
- 1970-04-29 ES ES379154A patent/ES379154A1/en not_active Expired
- 1970-04-29 ES ES379158A patent/ES379158A1/en not_active Expired
- 1970-04-29 ES ES379156A patent/ES379156A1/en not_active Expired
- 1970-06-23 ES ES381047A patent/ES381047A1/en not_active Expired
- 1970-06-29 ES ES381048A patent/ES381048A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES379154A1 (en) | 1973-02-01 |
| ES379158A1 (en) | 1973-02-01 |
| ES379157A1 (en) | 1973-02-01 |
| GB1280551A (en) | 1972-07-05 |
| ES368946A1 (en) | 1971-07-16 |
| ES381047A1 (en) | 1973-03-16 |
| ES379155A1 (en) | 1973-02-01 |
| ES379160A1 (en) | 1973-02-01 |
| ES379159A1 (en) | 1973-02-01 |
| ES381048A1 (en) | 1973-04-01 |
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