ES374359A1 - Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES374359A1
ES374359A1 ES374359A ES374359A ES374359A1 ES 374359 A1 ES374359 A1 ES 374359A1 ES 374359 A ES374359 A ES 374359A ES 374359 A ES374359 A ES 374359A ES 374359 A1 ES374359 A1 ES 374359A1
Authority
ES
Spain
Prior art keywords
radical
atom
formula
alkyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES374359A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1778069A external-priority patent/CH521983A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES374359A1 publication Critical patent/ES374359A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedure for obtaining 1,2-dihydro-pyrido- [2,3-d] pyrimidin-2-one of formula Ic, **(See formula)** where R means a hydrogen atom, an alkyl radical of 1 to 5 carbon atoms, R1 means an alkyl radical of 1 to 6 carbon atoms, other than a third alkyl group in which the third carbon atom is directly linked to the nitrogen atom in the ring, a 3- to 6-membered cycloalkyl radical in the ring, or the allyl, metalyl, or propargyl radical, and R 2 means the phenyl radical or a substituted phenyl radical of formula II, **(See formula)** where Y means a fluorine, chlorine or bromine atom, or an alkyl or alkoxy radical of 1 to 4 carbon atoms, and Y1 means a hydrogen, fluorine, chlorine or bromine atom, or an alkyl or alkoxy radical of 1 to 4 4 carbon atoms, characterized in that a compound of formula III is reacted, **(See formula)** where R and R2 have the meanings indicated above, M'means an alkali metal atom, preferably sodium or potassium, with a compound of formula IV, R'1X IV where R'1 has the meaning indicated above, and X means a chlorine, bromine or iodine atom, preferably iodine, preferably in an organic solvent inert to the reaction conditions, and conveniently at a temperature of from 10 to 100ºC. (Machine-translation by Google Translate, not legally binding)
ES374359A 1968-12-10 1969-12-09 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding) Expired ES374359A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78274368A 1968-12-10 1968-12-10
CH1778069A CH521983A (en) 1968-12-10 1969-11-28 Process for the preparation of 4-phenyl-1,2-dihydropyrido (2,3-d) pyrimidin-2-ones

Publications (1)

Publication Number Publication Date
ES374359A1 true ES374359A1 (en) 1972-03-16

Family

ID=25720034

Family Applications (5)

Application Number Title Priority Date Filing Date
ES374359A Expired ES374359A1 (en) 1968-12-10 1969-12-09 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding)
ES389206A Expired ES389206A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding)
ES389207A Expired ES389207A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding)
ES389204A Expired ES389204A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2-dihydro-pyrid (2,3-d) pyrimidin 2 -onas. (Machine-translation by Google Translate, not legally binding)
ES389205A Expired ES389205A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 onas. (Machine-translation by Google Translate, not legally binding)

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES389206A Expired ES389206A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding)
ES389207A Expired ES389207A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 - onas. (Machine-translation by Google Translate, not legally binding)
ES389204A Expired ES389204A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2-dihydro-pyrid (2,3-d) pyrimidin 2 -onas. (Machine-translation by Google Translate, not legally binding)
ES389205A Expired ES389205A1 (en) 1968-12-10 1971-03-13 Procedure for the obtaining of 1,2 - dihydro - pyrid (2,3 - d) pyrimidin - 2 onas. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
CH (1) CH521984A (en)
ES (5) ES374359A1 (en)

Also Published As

Publication number Publication date
ES389204A1 (en) 1974-03-16
ES389207A1 (en) 1974-03-16
ES389205A1 (en) 1974-03-16
CH521984A (en) 1972-04-30
ES389206A1 (en) 1974-03-16

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