ES376668A1 - Procedure for the obtaining of quinazolinone derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining quinazolinone derivatives, of formula I, **(See formula)** wherein R is a fluorine, chlorine or bromine atom, an alkyl radical of 1 to 5 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms, an alkylthio radical of 1 to 4 carbon atoms, or a group hydroxyl, nitro, amino, cyano, acetamido, trifluoromethyl or mercapto, n represents 1 or 2, with the conditions i) that when n = 1, R does not mean a halogen atom, and ii) that when n = 2, each of the R's, which may be the same or different, represents an alkyl or alkoxy radical or a halogen atom, R1 means an alkyl radical of 1 to 5 carbon atoms, or an allyl or propargyl radical, with the proviso that R1 can only mean an isopropyl radical when n = 1 and R means a hydroxyl, amino, cyano, acetamido or mercapto group, and R2 means a phenyl radical or a substituted phenyl radical of formula II, wherein Y means a fluorine, chlorine or bromine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms, or a trifluoromethyl group, and means a hydrogen atom, a fluorine, chlorine or bromine atom, an alkyl radical of 1 to 4 carbon atoms, or an alkoxy radical of 1 to 4 carbon atoms, Y or Y1 not being alkoxy when R is hydroxy or mercapto, characterized in that a compound of formula VI is cyclized, **(See formula)** wherein R', n, R1, R2 and the conditions with respect to R, R1 and n are as defined above, with phosgene, preferably in an inert aromatic hydrocarbon solvent at a temperature of 10-30ºC using an excess of phosgene. (Machine-translation by Google Translate, not legally binding)