ES282087A1 - A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES282087A1
ES282087A1 ES282087A ES282087A ES282087A1 ES 282087 A1 ES282087 A1 ES 282087A1 ES 282087 A ES282087 A ES 282087A ES 282087 A ES282087 A ES 282087A ES 282087 A1 ES282087 A1 ES 282087A1
Authority
ES
Spain
Prior art keywords
refers
term
groups
lower alkyl
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES282087A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US149527A external-priority patent/US3136815A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES282087A1 publication Critical patent/ES282087A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a process for the manufacture of the compounds of the general formula ** formula ** wherein R, R1, R3, R4 and R5 have the meaning set forth above, with an alkylating or alkylating agent and, if desired, transforming the obtained compound into a salt. The term "lower alkyl" refers to straight chain and branched chain lower alkyl groups, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tercibutyl and the like. The term "lower alkenyl" refers to groups such as allyl butenyl (including the various isomers) and the like. The term "lower alkynyl" refers to groups such as propargyl and the like. The term "cyano-lower alkyl" refers to groups such as beta-cyanoethyl and the like. The term "hydroxy-lower alkyl" refers to groups such as hydroxymethyl and beta-hydroxyethyl. The term "lower alkoxy-lower alkyl" refers to groups such as methoxymethyl and analogs. The term "halogen" refers to all four halogens, that is, iodine, bromine, chlorine, and fluorine. (Machine-translation by Google Translate, not legally binding)
ES282087A 1961-11-02 1962-10-31 A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) Expired ES282087A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US149527A US3136815A (en) 1959-12-10 1961-11-02 Amino substituted benzophenone oximes and derivatives thereof

Publications (1)

Publication Number Publication Date
ES282087A1 true ES282087A1 (en) 1963-03-16

Family

ID=22530691

Family Applications (2)

Application Number Title Priority Date Filing Date
ES282088A Expired ES282088A1 (en) 1961-11-02 1962-10-31 A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)
ES282087A Expired ES282087A1 (en) 1961-11-02 1962-10-31 A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES282088A Expired ES282088A1 (en) 1961-11-02 1962-10-31 A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
BE (2) BE624168A (en)
BR (1) BR6244259D0 (en)
CH (2) CH420177A (en)
DK (2) DK116365B (en)
ES (2) ES282088A1 (en)
FR (1) FR2979M (en)
GB (2) GB988635A (en)
SE (2) SE302126B (en)

Also Published As

Publication number Publication date
GB988635A (en) 1965-04-07
SE301980B (en) 1968-07-01
BR6244259D0 (en) 1973-05-24
ES282088A1 (en) 1963-03-16
DE1445866A1 (en) 1969-03-13
BE624169A (en) 1963-04-29
FR2979M (en) 1964-12-07
CH420176A (en) 1966-09-15
DE1445865A1 (en) 1969-03-13
BE624168A (en) 1963-04-29
CH420177A (en) 1966-09-15
DK116365B (en) 1970-01-05
DK116287B (en) 1969-12-29
GB988634A (en) 1965-04-07
SE302126B (en) 1968-07-08

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