ES378469A1 - Procedimiento para la preparacion de 17 - esteres de 2-an- drosteno basicos. - Google Patents
Procedimiento para la preparacion de 17 - esteres de 2-an- drosteno basicos.Info
- Publication number
- ES378469A1 ES378469A1 ES378469A ES378469A ES378469A1 ES 378469 A1 ES378469 A1 ES 378469A1 ES 378469 A ES378469 A ES 378469A ES 378469 A ES378469 A ES 378469A ES 378469 A1 ES378469 A1 ES 378469A1
- Authority
- ES
- Spain
- Prior art keywords
- androstene
- prepared
- steroids
- diethylaminoethoxy
- androstan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- NTDNQJMXFXTZLE-FZFXZXLVSA-N (8s,9s,10s,13s,14s)-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene Chemical class C1CC2CC=CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 NTDNQJMXFXTZLE-FZFXZXLVSA-N 0.000 title 1
- 150000003431 steroids Chemical class 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 3
- IBYHHJPAARCAIE-UHFFFAOYSA-N 1-bromo-2-chloroethane Chemical compound ClCCBr IBYHHJPAARCAIE-UHFFFAOYSA-N 0.000 abstract 2
- KBXXJWDSHUJCMA-UHFFFAOYSA-N 3-(oxan-3-yloxy)oxane Chemical compound C1CCOCC1OC1COCCC1 KBXXJWDSHUJCMA-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 abstract 2
- VIWZVFVJPXTXPA-UHFFFAOYSA-N N-(2-Carboxymethyl)-morpholine Chemical compound OC(=O)CN1CCOCC1 VIWZVFVJPXTXPA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- LILXDMFJXYAKMK-UHFFFAOYSA-N 2-bromo-1,1-diethoxyethane Chemical compound CCOC(CBr)OCC LILXDMFJXYAKMK-UHFFFAOYSA-N 0.000 abstract 1
- AAOSLLBWWRKJIR-UHFFFAOYSA-N 2-chloro-1-pyrrolidin-1-ylethanone Chemical compound ClCC(=O)N1CCCC1 AAOSLLBWWRKJIR-UHFFFAOYSA-N 0.000 abstract 1
- YMDNODNLFSHHCV-UHFFFAOYSA-N 2-chloro-n,n-diethylethanamine Chemical compound CCN(CC)CCCl YMDNODNLFSHHCV-UHFFFAOYSA-N 0.000 abstract 1
- ITMDXELACFVLRU-XJLOBVJASA-N 3-[[(8S,9S,10S,13S,14S)-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]propan-1-amine Chemical compound NCCCOC=1CC2CC[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]3[C@]2(CC1)C ITMDXELACFVLRU-XJLOBVJASA-N 0.000 abstract 1
- ZOACGIMDWGMJFJ-UHFFFAOYSA-N 4-bromobutanoic acid nitrous acid Chemical compound N(=O)O.BrCCCC(=O)O ZOACGIMDWGMJFJ-UHFFFAOYSA-N 0.000 abstract 1
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 238000007126 N-alkylation reaction Methods 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 230000000326 anti-hypercholesterolaemic effect Effects 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 238000007278 cyanoethylation reaction Methods 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 pyrrolidino, piperidino, hexamethyleneimino, 1-piperazinyl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691918699 DE1918699A1 (de) | 1969-04-12 | 1969-04-12 | 2-Androsten-17-aether und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES378469A1 true ES378469A1 (es) | 1972-06-16 |
Family
ID=5731050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES378469A Expired ES378469A1 (es) | 1969-04-12 | 1970-04-11 | Procedimiento para la preparacion de 17 - esteres de 2-an- drosteno basicos. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS4843903B1 (https=) |
| AT (2) | AT302546B (https=) |
| BE (1) | BE748720A (https=) |
| BR (1) | BR6915479D0 (https=) |
| CH (1) | CH533607A (https=) |
| CS (1) | CS149424B2 (https=) |
| DE (1) | DE1918699A1 (https=) |
| DK (1) | DK129989B (https=) |
| ES (1) | ES378469A1 (https=) |
| FR (1) | FR2042324B1 (https=) |
| GB (1) | GB1264941A (https=) |
| IL (1) | IL34217A (https=) |
| NL (1) | NL7004608A (https=) |
| SE (1) | SE349299B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020108070A (ja) | 2018-12-28 | 2020-07-09 | 株式会社東芝 | 通信制御装置および通信制御システム |
-
1969
- 1969-04-12 DE DE19691918699 patent/DE1918699A1/de active Pending
- 1969-12-19 BR BR215479/69A patent/BR6915479D0/pt unknown
-
1970
- 1970-03-19 GB GB1264941D patent/GB1264941A/en not_active Expired
- 1970-03-31 CS CS368A patent/CS149424B2/cs unknown
- 1970-03-31 IL IL34217A patent/IL34217A/en unknown
- 1970-04-01 NL NL7004608A patent/NL7004608A/xx unknown
- 1970-04-03 DK DK169170AA patent/DK129989B/da unknown
- 1970-04-06 CH CH503170A patent/CH533607A/de not_active IP Right Cessation
- 1970-04-08 AT AT1107570A patent/AT302546B/de not_active IP Right Cessation
- 1970-04-08 AT AT321970A patent/AT296515B/de not_active IP Right Cessation
- 1970-04-08 SE SE04771/70A patent/SE349299B/xx unknown
- 1970-04-09 BE BE748720D patent/BE748720A/xx unknown
- 1970-04-10 FR FR707012963A patent/FR2042324B1/fr not_active Expired
- 1970-04-11 ES ES378469A patent/ES378469A1/es not_active Expired
- 1970-04-11 JP JP45030709A patent/JPS4843903B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1918699A1 (de) | 1970-10-15 |
| IL34217A0 (en) | 1970-05-21 |
| CH533607A (de) | 1973-02-15 |
| JPS4843903B1 (https=) | 1973-12-21 |
| FR2042324B1 (https=) | 1973-08-10 |
| AT296515B (de) | 1972-02-25 |
| CS149424B2 (https=) | 1973-07-05 |
| BE748720A (fr) | 1970-10-09 |
| DK129989B (da) | 1974-12-09 |
| IL34217A (en) | 1973-03-30 |
| AT302546B (de) | 1972-10-25 |
| FR2042324A1 (https=) | 1971-02-12 |
| BR6915479D0 (pt) | 1973-01-25 |
| NL7004608A (https=) | 1970-10-14 |
| SE349299B (https=) | 1972-09-25 |
| DK129989C (https=) | 1975-05-20 |
| GB1264941A (https=) | 1972-02-23 |
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