ES378312A1 - Procedure for the preparation of new 5-aril-1H-1,5- benzodiazepin - 2,4-dionas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new 5-aryl-1H-1,5-benzodiazepin-2,4-diones, which consist of a group of compounds of the general formulas: **(See formula)** wherein R1 signifies hydrogen, a straight or branched alcohol radical with 1 to 4 carbon atoms, which is substituted by a hydroxy or acyloxy group, a dialkoxy amino group with 2 to 4 carbon atoms, the allyl radical, the cyclohexyl radical, a phenyl radical, which may optionally be substituted once or twice by the methyl or methoxy group, or a halogen atom, or the benzyl radical; R2 means the naphthyl, pyrimidinyl, thienyl or pyridyl radical, the latter possibly being substituted by a methyl group or a halogen atom; R3 signifies hydrogen, the trifluoromethyl or cyano group, a halogen atom or an acyl or lower alkoxycarbonyl group, with 1 or 2 carbon atoms; R4 signifies hydrogen, the trifluoromethyl, cyano or nitro group, a halogen atom or an acyl or lower alkoxycarbonyl group; R5 signifies the cyano group or a lower acyl or alkoxycarbonyl group; R6 signifies the cyano or nitro group or a lower acyl or alkoxycarbonyl group; R7 means the trifluoromethyl group or a halogen atom, characterized in that a 2-aminodiphenyl-amine or 2-amino-phenyl-heteroaryl-amine is reacted with a malonic acid dihalogenide, and the compound thus obtained is alcoholized, optionally, in position 1. (Machine-translation by Google Translate, not legally binding)