ES375613A1 - Metodo para preparar 21-esteres de coticosteroides. - Google Patents
Metodo para preparar 21-esteres de coticosteroides.Info
- Publication number
- ES375613A1 ES375613A1 ES375613A ES375613A ES375613A1 ES 375613 A1 ES375613 A1 ES 375613A1 ES 375613 A ES375613 A ES 375613A ES 375613 A ES375613 A ES 375613A ES 375613 A1 ES375613 A1 ES 375613A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- chloroethyl
- bis
- compounds
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Corticoid steroid compounds Chemical class 0.000 title 1
- 239000003470 adrenal cortex hormone Substances 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- PDUQYHSWRUIXCI-UHFFFAOYSA-N 2-[4-[bis(2-chloroethyl)amino]phenyl]-2-methylpropanoyl chloride Chemical compound ClCCN(CCCl)C1=CC=C(C=C1)C(C(=O)Cl)(C)C PDUQYHSWRUIXCI-UHFFFAOYSA-N 0.000 abstract 1
- JSDITRAWIKWHTB-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-4-methylbenzoyl chloride Chemical compound ClCCN(CCCl)C=1C=C(C=CC1C(=O)Cl)C JSDITRAWIKWHTB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 1
- FYWSBUKNPDTATO-UHFFFAOYSA-N 3-[4-[bis(2-chloroethyl)amino]phenyl]butanoyl 3-[4-[bis(2-chloroethyl)amino]phenyl]butanoate Chemical compound ClCCN(CCCl)C1=CC=C(C=C1)C(CC(=O)OC(CC(C)C1=CC=C(C=C1)N(CCCl)CCCl)=O)C FYWSBUKNPDTATO-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- UVCLSTMPJQIITB-UHFFFAOYSA-N [2-[4-[bis(2-chloroethyl)amino]phenyl]sulfanylacetyl] 2-[4-[bis(2-chloroethyl)amino]phenyl]sulfanylacetate Chemical compound ClCCN(CCCl)C1=CC=C(C=C1)SCC(=O)OC(CSC1=CC=C(C=C1)N(CCCl)CCCl)=O UVCLSTMPJQIITB-UHFFFAOYSA-N 0.000 abstract 1
- IIUCZXAVDYFVJA-UHFFFAOYSA-N [2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl] 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate Chemical compound C=1C=C(N(CCCl)CCCl)C=CC=1CC(NC(C)=O)C(=O)OC(=O)C(NC(=O)C)CC1=CC=C(N(CCCl)CCCl)C=C1 IIUCZXAVDYFVJA-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3952/69A GB1272841A (en) | 1969-01-23 | 1969-01-23 | New corticoid steroid compounds of cytostatic interest |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES375613A1 true ES375613A1 (es) | 1972-10-16 |
Family
ID=9767981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES375613A Expired ES375613A1 (es) | 1969-01-23 | 1970-01-19 | Metodo para preparar 21-esteres de coticosteroides. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3732260A (OSRAM) |
| AT (1) | AT300212B (OSRAM) |
| BE (1) | BE744766A (OSRAM) |
| BR (1) | BR7016251D0 (OSRAM) |
| CA (1) | CA935152A (OSRAM) |
| CH (1) | CH534143A (OSRAM) |
| DE (1) | DE2001305C3 (OSRAM) |
| DK (1) | DK123713B (OSRAM) |
| ES (1) | ES375613A1 (OSRAM) |
| FI (1) | FI47659C (OSRAM) |
| FR (1) | FR2034483B1 (OSRAM) |
| GB (1) | GB1272841A (OSRAM) |
| IE (1) | IE33953B1 (OSRAM) |
| NL (1) | NL160570C (OSRAM) |
| NO (1) | NO130476C (OSRAM) |
| SE (1) | SE358387B (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1036870B (it) * | 1975-02-13 | 1979-10-30 | Acraf | Derivati steroidei dell acido bendazolico |
| US4261910A (en) * | 1978-08-14 | 1981-04-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | Process for the preparation of Chlorambucil derivatives |
| US4810701A (en) * | 1984-07-31 | 1989-03-07 | Vsesojuzny Onkologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk Ssr | 11-desoxy-17α-hydroxycorticosterone derivatives |
| CN1543356B (zh) * | 2001-06-25 | 2011-09-28 | 味之素株式会社 | 抗肿瘤剂 |
| EP2282724B1 (en) * | 2008-05-23 | 2018-09-05 | The University Of British Columbia | Modified drugs for use in liposomal nanoparticles |
-
1969
- 1969-01-23 GB GB3952/69A patent/GB1272841A/en not_active Expired
-
1970
- 1970-01-13 DE DE2001305A patent/DE2001305C3/de not_active Expired
- 1970-01-13 NO NO123/70A patent/NO130476C/no unknown
- 1970-01-14 CH CH49670A patent/CH534143A/de not_active IP Right Cessation
- 1970-01-19 US US00004067A patent/US3732260A/en not_active Expired - Lifetime
- 1970-01-19 ES ES375613A patent/ES375613A1/es not_active Expired
- 1970-01-19 FI FI700138A patent/FI47659C/fi active
- 1970-01-20 SE SE00674/70A patent/SE358387B/xx unknown
- 1970-01-21 IE IE80/70A patent/IE33953B1/xx unknown
- 1970-01-21 FR FR7002113A patent/FR2034483B1/fr not_active Expired
- 1970-01-22 DK DK29470AA patent/DK123713B/da not_active IP Right Cessation
- 1970-01-22 CA CA072847A patent/CA935152A/en not_active Expired
- 1970-01-22 BE BE744766D patent/BE744766A/xx not_active IP Right Cessation
- 1970-01-23 BR BR216251/70A patent/BR7016251D0/pt unknown
- 1970-01-23 NL NL7000977.A patent/NL160570C/xx not_active IP Right Cessation
- 1970-01-23 AT AT64870A patent/AT300212B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AT300212B (de) | 1972-07-25 |
| FR2034483B1 (OSRAM) | 1974-02-01 |
| NO130476C (OSRAM) | 1974-12-18 |
| NL160570B (nl) | 1979-06-15 |
| US3732260A (en) | 1973-05-08 |
| FI47659C (fi) | 1974-02-11 |
| BR7016251D0 (pt) | 1973-01-25 |
| DE2001305A1 (de) | 1970-08-27 |
| GB1272841A (en) | 1972-05-03 |
| CH534143A (de) | 1973-02-28 |
| DK123713B (da) | 1972-07-24 |
| IE33953L (en) | 1970-07-23 |
| FR2034483A1 (OSRAM) | 1970-12-11 |
| NL160570C (nl) | 1979-11-15 |
| BE744766A (fr) | 1970-07-01 |
| NO130476B (OSRAM) | 1974-09-09 |
| DE2001305C3 (de) | 1975-05-07 |
| DE2001305B2 (de) | 1974-08-15 |
| FI47659B (OSRAM) | 1973-10-31 |
| NL7000977A (OSRAM) | 1970-07-27 |
| CA935152A (en) | 1973-10-09 |
| IE33953B1 (en) | 1974-12-30 |
| SE358387B (OSRAM) | 1973-07-30 |
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