ES374475A1 - Improvements in or relating to benzylideneamino guanidine derivatives - Google Patents
Improvements in or relating to benzylideneamino guanidine derivativesInfo
- Publication number
- ES374475A1 ES374475A1 ES374475A ES374475A ES374475A1 ES 374475 A1 ES374475 A1 ES 374475A1 ES 374475 A ES374475 A ES 374475A ES 374475 A ES374475 A ES 374475A ES 374475 A1 ES374475 A1 ES 374475A1
- Authority
- ES
- Spain
- Prior art keywords
- reacting
- prepared
- appropriate benzaldehyde
- relating
- guanidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Novel compounds I: where R 1 and R 2 are H, Cl or F, with the proviso that the benzene ring is at least monosubstituted, are prepared by reacting an appropriate benzaldehyde with 1-amino-3-hydroxy-guanidine or reacting an appropriate benzaldehyde 5-alkylisothiosemicarbazone III: where R 3 is 1-4 C alkyl with hydroxylamine. Compounds III may be prepared by reacting an apropriate thiosemicarbazone with an alkyl halide to give the acid addition salt followed by formation of the free base. The thiosemicarbazones may be prepared by reacting an appropriate benzaldehyde with Pharmaceutical compositions comprise a compound I together with a suitable excipient and have hypotensive activity when administered orally or parenterally.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69930968A | 1968-01-22 | 1968-01-22 | |
| US74361368A | 1968-07-10 | 1968-07-10 | |
| US76235668A | 1968-09-16 | 1968-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES374475A1 true ES374475A1 (en) | 1972-04-01 |
Family
ID=27418682
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES362712A Expired ES362712A1 (en) | 1968-01-22 | 1969-01-20 | Improvements in or relating to benzylideneamino guanidine derivatives |
| ES374472A Expired ES374472A1 (en) | 1968-01-22 | 1969-12-12 | Improvements in or relating to benzylideneamino guanidine derivatives |
| ES374475A Expired ES374475A1 (en) | 1968-01-22 | 1969-12-12 | Improvements in or relating to benzylideneamino guanidine derivatives |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES362712A Expired ES362712A1 (en) | 1968-01-22 | 1969-01-20 | Improvements in or relating to benzylideneamino guanidine derivatives |
| ES374472A Expired ES374472A1 (en) | 1968-01-22 | 1969-12-12 | Improvements in or relating to benzylideneamino guanidine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| BE (1) | BE727146A (en) |
| CA (1) | CA953735A (en) |
| CH (2) | CH537370A (en) |
| DE (1) | DE1902449C2 (en) |
| ES (3) | ES362712A1 (en) |
| FR (3) | FR2000512B1 (en) |
| GB (2) | GB1253548A (en) |
| IE (1) | IE32943B1 (en) |
| IL (1) | IL31452A (en) |
| MX (1) | MX3183E (en) |
| NL (1) | NL6818769A (en) |
| SE (1) | SE374740B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH523232A (en) * | 1968-12-16 | 1972-05-31 | Sandoz Ag | Process for the preparation of a benzylidene aminoguanidine |
| FR2324294A1 (en) * | 1975-09-22 | 1977-04-15 | Roussel Uclaf | NEW DELAYED-ACTION HYPOTENSIVE MEDICINAL PRODUCT, AS WELL AS THE PROCESS FOR PREPARING THIS NEW MEDICINAL PRODUCT |
-
1968
- 1968-12-17 CH CH1877568A patent/CH537370A/en not_active IP Right Cessation
- 1968-12-17 CH CH1767870A patent/CH537372A/en not_active IP Right Cessation
- 1968-12-27 NL NL6818769A patent/NL6818769A/xx unknown
- 1968-12-30 GB GB61608/68A patent/GB1253548A/en not_active Expired
- 1968-12-30 GB GB09402/71A patent/GB1253549A/en not_active Expired
-
1969
- 1969-01-02 SE SE6900010A patent/SE374740B/xx unknown
- 1969-01-03 MX MX002449U patent/MX3183E/en unknown
- 1969-01-18 DE DE1902449A patent/DE1902449C2/en not_active Expired
- 1969-01-20 IL IL31452A patent/IL31452A/en unknown
- 1969-01-20 FR FR696900894A patent/FR2000512B1/fr not_active Expired
- 1969-01-20 BE BE727146D patent/BE727146A/xx not_active IP Right Cessation
- 1969-01-20 ES ES362712A patent/ES362712A1/en not_active Expired
- 1969-01-20 IE IE74/69A patent/IE32943B1/en unknown
- 1969-01-21 CA CA040,689A patent/CA953735A/en not_active Expired
- 1969-12-12 ES ES374472A patent/ES374472A1/en not_active Expired
- 1969-12-12 ES ES374475A patent/ES374475A1/en not_active Expired
-
1970
- 1970-04-03 FR FR7012104A patent/FR2059987A1/fr not_active Withdrawn
- 1970-04-03 FR FR7012103A patent/FR2061583A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CH537370A (en) | 1973-05-31 |
| DE1902449C2 (en) | 1983-10-20 |
| MX3183E (en) | 1980-06-17 |
| FR2059987A1 (en) | 1971-06-11 |
| IE32943B1 (en) | 1974-01-23 |
| FR2000512B1 (en) | 1973-01-12 |
| FR2061583A1 (en) | 1971-06-25 |
| BE727146A (en) | 1969-07-22 |
| DE1902449A1 (en) | 1969-08-28 |
| SE374740B (en) | 1975-03-17 |
| IL31452A0 (en) | 1969-03-27 |
| ES362712A1 (en) | 1970-11-16 |
| GB1253548A (en) | 1971-11-17 |
| CH537372A (en) | 1973-07-13 |
| GB1253549A (en) | 1971-11-17 |
| ES374472A1 (en) | 1972-04-01 |
| IL31452A (en) | 1972-06-28 |
| FR2000512A1 (en) | 1969-09-12 |
| NL6818769A (en) | 1969-07-24 |
| IE32943L (en) | 1969-07-22 |
| CA953735A (en) | 1974-08-27 |
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