ES369920A1 - Procedure for preparing vinyl-substitute ftalans. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing vinyl-substitute ftalans. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES369920A1 ES369920A1 ES369920A ES369920A ES369920A1 ES 369920 A1 ES369920 A1 ES 369920A1 ES 369920 A ES369920 A ES 369920A ES 369920 A ES369920 A ES 369920A ES 369920 A1 ES369920 A1 ES 369920A1
- Authority
- ES
- Spain
- Prior art keywords
- piperazinyl
- alkoxycarbonyl
- alkyl
- compounds
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises compounds of formula and their non-toxic acid addition salts, wherein R 1 -R 3 and R 5 -R 7 are H or alkyl (or R 3 is alkoxycarbonyl) R 4 is alkyl (or NR 3 R 4 may be 4-morpholinyl, polymethyleneimino, 1-piperazinyl, 1-alkyl-4-piperazinyl or 1-alkoxycarbonyl-4-piperazinyl) R 8 is thienyl, furyl, indonyl, naphthyl, alkoxynaphthyl, or phenyl (possibly substituted by cycloalkyl, halogen, alkyl, phenyl or 1-3 methoxy groups) and n is 1-3. These compounds are prepared by (a) reacting a compound of formula with one of formula halogen-MgCH 2 CHR 5 (CH 2 ) n NR 3 R 4 (b) [to obtain compounds where R 3 is alkoxycarbonyl or NR 3 R 4 is 1 -alkoxycarbonyl-4-piperazinyl] reacting a corresponding compound where R 3 is methyl or NR 3 R 4 is 1-methyl-4 piperazinyl, with an alkoxycarbonyl halide (c) [to obtain compounds where R 3 is H or NR 3 R 4 is 1-piperazinyl] saponification of the products of method (b) (d) [to obtain the compound where R 1 , R 2 and R 5 -R 7 are H and R 3 , R 4 are Me] treating 4-dimethytamino-1-(2- hydroxymethylphenyl) - 1 - styrylbutanol with HCl. Other starting materials and intermediates for which preparative details are given are:- 1 - ethyl - 1 - (2 - propionylphenyl) propanol 1 - styrylphthalanol and its 3,3-dimethyl and [alpha],3,3-trimethyl derivatives and 1,1,3-trimethylisobenzofurylium perchlorate. Therapeutic compositions for oral or parenteral administration comprise compounds of the first general formula, above, which are C.N.S.-antidepressants, and pharmaceutically acceptable carriers or diluents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74783268A | 1968-07-26 | 1968-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES369920A1 true ES369920A1 (en) | 1971-07-16 |
Family
ID=25006833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES369920A Expired ES369920A1 (en) | 1968-07-26 | 1969-07-26 | Procedure for preparing vinyl-substitute ftalans. (Machine-translation by Google Translate, not legally binding) |
Country Status (11)
Country | Link |
---|---|
AT (1) | AT289775B (en) |
BE (1) | BE736590A (en) |
BR (1) | BR6911054D0 (en) |
CH (1) | CH519495A (en) |
DE (1) | DE1937928A1 (en) |
ES (1) | ES369920A1 (en) |
FR (1) | FR2013793A1 (en) |
GB (1) | GB1225216A (en) |
IL (1) | IL32453A (en) |
NL (1) | NL6910936A (en) |
SE (1) | SE365213B (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1173312A (en) * | 1966-03-17 | 1969-12-10 | Kefalas As | Heterocyclic Compounds |
-
1969
- 1969-06-13 GB GB1225216D patent/GB1225216A/en not_active Expired
- 1969-06-23 IL IL32453A patent/IL32453A/en unknown
- 1969-07-16 NL NL6910936A patent/NL6910936A/xx unknown
- 1969-07-24 SE SE10473/69A patent/SE365213B/xx unknown
- 1969-07-24 FR FR6925242A patent/FR2013793A1/fr not_active Withdrawn
- 1969-07-25 BR BR211054/69A patent/BR6911054D0/en unknown
- 1969-07-25 DE DE19691937928 patent/DE1937928A1/en active Pending
- 1969-07-25 AT AT722669A patent/AT289775B/en active
- 1969-07-25 BE BE736590D patent/BE736590A/xx unknown
- 1969-07-25 CH CH1139169A patent/CH519495A/en not_active IP Right Cessation
- 1969-07-26 ES ES369920A patent/ES369920A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL32453A (en) | 1972-12-29 |
NL6910936A (en) | 1970-01-29 |
CH519495A (en) | 1972-02-29 |
BE736590A (en) | 1970-01-26 |
IL32453A0 (en) | 1969-08-27 |
SE365213B (en) | 1974-03-18 |
GB1225216A (en) | 1971-03-17 |
AT289775B (en) | 1971-05-10 |
FR2013793A1 (en) | 1970-04-10 |
BR6911054D0 (en) | 1973-05-08 |
DE1937928A1 (en) | 1970-01-29 |
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