ES359987A1 - Procedure for obtaining peptides of hypocalcenic effectiveness. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining peptides of hypocalcemic efficacy of formula i: ** (see formula) ** Or the corresponding compounds, in which one or more of the asparagine residues are substituted by the asparaginic acid moiety and/or the glutamine acid moiety is substituted by the glutamine moiety and/or the methionine moiety is substituted by the rest valine, norvaline, leucine, isoleucine or norleucine or its acid addition salts, derivatives or complexes, characterized in that of the compounds of formula i or of the aforementioned analogs or derivatives of these compounds, in which at least the α -amino radical and the carboxyl terminal and side chain radicals are protected, the protecting groups are dissociated, or the compounds of formula ii: ** (see formula) ** Or the aforementioned analogs or derivatives are oxidized to disulfides, or the compounds of formula ii or the analogs or derivatives mentioned, in which the mercapto radicals are protected by the trityl radical, are directly oxidized to disulfides, or the compounds of formula iii or iv: ** (see formula) ** Wherein a represents 1 to 21 of the amino acid residues following cysteine7 and r means hydrogen or an amino acylated radical, is condensed with the remaining c-terminal sequence of the peptide, according to the methods known in the synthesis of the peptides, under the condition that the azide method or the anhydride method or the activated ester method is used when the c-terminal sequence shows a free carboxyl radical, and, if desired, dissociates the α -acyl radical; and, if if desired, the compounds obtained are transformed into their acid addition salts, derivatives or complexes. (Machine-translation by Google Translate, not legally binding)