ES357071A1 - Un procedimiento para la obtencion de un preparado farma- ceutico apto para administracion oral. - Google Patents
Un procedimiento para la obtencion de un preparado farma- ceutico apto para administracion oral.Info
- Publication number
- ES357071A1 ES357071A1 ES357071A ES357071A ES357071A1 ES 357071 A1 ES357071 A1 ES 357071A1 ES 357071 A ES357071 A ES 357071A ES 357071 A ES357071 A ES 357071A ES 357071 A1 ES357071 A1 ES 357071A1
- Authority
- ES
- Spain
- Prior art keywords
- base
- resin
- imipramine
- polymer containing
- carrier liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003729 cation exchange resin Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940023913 cation exchange resins Drugs 0.000 title 1
- 125000003367 polycyclic group Chemical group 0.000 title 1
- 239000002585 base Substances 0.000 abstract 5
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 abstract 4
- 239000011347 resin Substances 0.000 abstract 4
- 229920005989 resin Polymers 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- YNZFUWZUGRBMHL-UHFFFAOYSA-N 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol Chemical compound C1CN(CCO)CCN1CCCN1C2=CC=CC=C2C=CC2=CC=CC=C21 YNZFUWZUGRBMHL-UHFFFAOYSA-N 0.000 abstract 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 abstract 1
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229960004606 clomipramine Drugs 0.000 abstract 1
- 239000000084 colloidal system Substances 0.000 abstract 1
- 239000003086 colorant Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003914 desipramine Drugs 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229960004801 imipramine Drugs 0.000 abstract 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- PXHIRIWYXDUSMR-UHFFFAOYSA-N ketipramine Chemical compound C1C(=O)C2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 PXHIRIWYXDUSMR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 abstract 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005290 opipramol Drugs 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Loading And Unloading Of Fuel Tanks Or Ships (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB37136/67A GB1176194A (en) | 1967-08-12 | 1967-08-12 | Pharmaceutical Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES357071A1 true ES357071A1 (es) | 1970-02-16 |
Family
ID=10394029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES357071A Expired ES357071A1 (es) | 1967-08-12 | 1968-08-09 | Un procedimiento para la obtencion de un preparado farma- ceutico apto para administracion oral. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3665073A (esLanguage) |
| JP (1) | JPS4823889B1 (esLanguage) |
| AT (1) | AT288592B (esLanguage) |
| BE (1) | BE719263A (esLanguage) |
| CA (1) | CA920949A (esLanguage) |
| CS (1) | CS159232B2 (esLanguage) |
| CY (1) | CY681A (esLanguage) |
| DE (1) | DE1792233B1 (esLanguage) |
| DK (1) | DK123141B (esLanguage) |
| ES (1) | ES357071A1 (esLanguage) |
| FI (1) | FI48974C (esLanguage) |
| FR (1) | FR7751M (esLanguage) |
| GB (1) | GB1176194A (esLanguage) |
| IE (1) | IE32264B1 (esLanguage) |
| IL (1) | IL30529A (esLanguage) |
| MY (1) | MY7300271A (esLanguage) |
| NL (1) | NL6811233A (esLanguage) |
| NO (1) | NO128308B (esLanguage) |
| SE (1) | SE376548B (esLanguage) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3762266A (en) * | 1970-11-09 | 1973-10-02 | Gould Inc | Bimetal fastener |
| US3947572A (en) * | 1974-07-01 | 1976-03-30 | Abbott Laboratories | Iron-resin adsorbate |
| US4015599A (en) * | 1975-07-21 | 1977-04-05 | Rohm And Haas Company | Anesthetic delivery system |
| JPS64734U (esLanguage) * | 1987-06-20 | 1989-01-05 | ||
| SE9103110D0 (sv) | 1991-10-24 | 1991-10-24 | Kabi Pharmacia Ab | New drug formulation |
| US6495154B1 (en) * | 2000-11-21 | 2002-12-17 | Vivus Inc. | On demand administration of clomipramine and salts thereof to treat premature ejaculation |
| US20030099711A1 (en) * | 2001-08-29 | 2003-05-29 | David Meadows | Sustained release preparations |
| MXPA04003567A (es) * | 2001-10-17 | 2005-04-11 | Minrad Inc | Sistema de liberacion de farmacos para sedacion conciente. |
| US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
| JP6577024B2 (ja) * | 2014-05-08 | 2019-09-18 | シーティーシー バイオ インコーポレイテッド | 味が遮蔽されたクロミプラミン含有経口投与用薬学製剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH383552A (de) * | 1958-10-24 | 1964-10-31 | Clinical Products Limited | Verfahren zur Herstellung von Harz-Arzneistoffverbindungen |
| US3138525A (en) * | 1961-06-16 | 1964-06-23 | Hoffmann La Roche | Castor wax-amprotropine-resin compositions |
| US3140978A (en) * | 1961-11-02 | 1964-07-14 | Hoffmann La Roche | Pharmaceutical composition containing complex magnesium aluminum silicate |
| US3337402A (en) * | 1963-09-03 | 1967-08-22 | Hoffmann La Roche | Stable and palatable pharmaceutical composition |
-
1967
- 1967-08-12 GB GB37136/67A patent/GB1176194A/en not_active Expired
-
1968
- 1968-08-07 NL NL6811233A patent/NL6811233A/xx unknown
- 1968-08-07 DK DK380168AA patent/DK123141B/da unknown
- 1968-08-07 NO NO03097/68A patent/NO128308B/no unknown
- 1968-08-07 SE SE6810626A patent/SE376548B/xx unknown
- 1968-08-07 FI FI682223A patent/FI48974C/fi active
- 1968-08-08 US US751047A patent/US3665073A/en not_active Expired - Lifetime
- 1968-08-08 DE DE19681792233 patent/DE1792233B1/de active Pending
- 1968-08-09 AT AT781468A patent/AT288592B/de not_active IP Right Cessation
- 1968-08-09 FR FR162492A patent/FR7751M/fr not_active Expired
- 1968-08-09 BE BE719263D patent/BE719263A/xx unknown
- 1968-08-09 JP JP43056233A patent/JPS4823889B1/ja active Pending
- 1968-08-09 ES ES357071A patent/ES357071A1/es not_active Expired
- 1968-08-09 CS CS579568A patent/CS159232B2/cs unknown
- 1968-08-09 IL IL30529A patent/IL30529A/en unknown
- 1968-08-09 IE IE977/68A patent/IE32264B1/xx unknown
- 1968-08-16 CA CA027603A patent/CA920949A/en not_active Expired
-
1973
- 1973-04-26 CY CY68173A patent/CY681A/xx unknown
- 1973-12-31 MY MY1973271A patent/MY7300271A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1176194A (en) | 1970-01-01 |
| BE719263A (esLanguage) | 1969-02-10 |
| NL6811233A (esLanguage) | 1969-02-14 |
| IL30529A (en) | 1972-04-27 |
| CS159232B2 (esLanguage) | 1974-12-27 |
| MY7300271A (en) | 1973-12-31 |
| SE376548B (esLanguage) | 1975-06-02 |
| JPS4823889B1 (esLanguage) | 1973-07-17 |
| IL30529A0 (en) | 1968-10-24 |
| DK123141B (da) | 1972-05-23 |
| IE32264B1 (en) | 1973-05-30 |
| FI48974C (fi) | 1975-03-10 |
| CA920949A (en) | 1973-02-13 |
| FI48974B (esLanguage) | 1974-12-02 |
| DE1792233B1 (de) | 1971-10-07 |
| AT288592B (de) | 1971-03-10 |
| IE32264L (en) | 1969-02-12 |
| FR7751M (esLanguage) | 1970-03-16 |
| US3665073A (en) | 1972-05-23 |
| CY681A (en) | 1973-04-26 |
| NO128308B (esLanguage) | 1973-10-29 |
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