ES356131A1 - Procedimiento de preparacion de nuevas amidinas aromaticas n-sustituidas. - Google Patents
Procedimiento de preparacion de nuevas amidinas aromaticas n-sustituidas.Info
- Publication number
- ES356131A1 ES356131A1 ES356131A ES356131A ES356131A1 ES 356131 A1 ES356131 A1 ES 356131A1 ES 356131 A ES356131 A ES 356131A ES 356131 A ES356131 A ES 356131A ES 356131 A1 ES356131 A1 ES 356131A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- general formula
- aromatic
- case
- phenyl radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 aromatic amidines Chemical class 0.000 title abstract 11
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 abstract 1
- FWEOQOXTVHGIFQ-UHFFFAOYSA-N 8-anilinonaphthalene-1-sulfonic acid Chemical class C=12C(S(=O)(=O)O)=CC=CC2=CC=CC=1NC1=CC=CC=C1 FWEOQOXTVHGIFQ-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical compound [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000003010 neurosedative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB32426/67A GB1188956A (en) | 1967-07-14 | 1967-07-14 | N-Substituted Aromatic Amidines and process for obtaining same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES356131A1 true ES356131A1 (es) | 1970-01-01 |
Family
ID=10338421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES356131A Expired ES356131A1 (es) | 1967-07-14 | 1968-07-13 | Procedimiento de preparacion de nuevas amidinas aromaticas n-sustituidas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3632593A (forum.php) |
| BE (1) | BE717740A (forum.php) |
| CH (1) | CH486427A (forum.php) |
| ES (1) | ES356131A1 (forum.php) |
| FR (2) | FR1580434A (forum.php) |
| GB (1) | GB1188956A (forum.php) |
| LU (1) | LU56454A1 (forum.php) |
| NL (1) | NL141508B (forum.php) |
| SE (1) | SE353085B (forum.php) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757955A (fr) * | 1969-10-24 | 1971-04-23 | Ici Ltd | Compositions antivirales |
| BE757956A (fr) * | 1969-10-24 | 1971-04-23 | Ici Ltd | Composes antiviraux |
| FR2081555A1 (en) * | 1970-03-02 | 1971-12-10 | Delalande Sa | N-aryl-n-naphthyl methyl benzamidines - analgesics hypotensives and diuretics |
| JPH06501002A (ja) * | 1990-08-30 | 1994-01-27 | オレゴン州 | シグマ受容体に対して高い結合性を有する置換アミジン類およびその使用 |
| WO1995005363A1 (en) * | 1993-08-12 | 1995-02-23 | Astra Aktiebolag | Amidine derivatives with nitric oxide synthetase activities |
| DK0724435T3 (da) * | 1993-10-21 | 2002-11-25 | Searle & Co | Amidinoderivater, der er nyttige som nitrogenoxid-synthase-inhibitorer |
| AU682768B2 (en) * | 1994-05-07 | 1997-10-16 | Astra Aktiebolag | Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase |
| AU3496297A (en) * | 1996-06-25 | 1998-01-14 | Eli Lilly And Company | Anticoagulant agents |
| US6200967B1 (en) * | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
| US6258822B1 (en) * | 1997-08-06 | 2001-07-10 | Abbott Laboratories | Urokinase inhibitors |
| US6504031B1 (en) | 1998-08-06 | 2003-01-07 | Milan Bruncko | Naphthamidine urokinase inhibitors |
| US6495562B1 (en) | 2000-04-25 | 2002-12-17 | Abbott Laboratories | Naphthamidine urokinase inhibitors |
| US10610368B2 (en) | 2018-05-26 | 2020-04-07 | Acumed Llc | Ankle fusion system with expandable spacer |
-
1967
- 1967-07-14 GB GB32426/67A patent/GB1188956A/en not_active Expired
-
1968
- 1968-07-05 BE BE717740D patent/BE717740A/xx unknown
- 1968-07-09 US US743332A patent/US3632593A/en not_active Expired - Lifetime
- 1968-07-09 FR FR1580434D patent/FR1580434A/fr not_active Expired
- 1968-07-09 CH CH1027668A patent/CH486427A/fr not_active IP Right Cessation
- 1968-07-10 LU LU56454D patent/LU56454A1/xx unknown
- 1968-07-10 FR FR158557A patent/FR8334M/fr not_active Expired
- 1968-07-12 NL NL686809956A patent/NL141508B/xx unknown
- 1968-07-12 SE SE09640/68A patent/SE353085B/xx unknown
- 1968-07-13 ES ES356131A patent/ES356131A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1580434A (forum.php) | 1969-09-05 |
| DE1768908A1 (de) | 1972-04-13 |
| CH486427A (fr) | 1970-02-28 |
| BE717740A (forum.php) | 1969-01-06 |
| LU56454A1 (forum.php) | 1969-05-21 |
| SE353085B (forum.php) | 1973-01-22 |
| US3632593A (en) | 1972-01-04 |
| GB1188956A (en) | 1970-04-22 |
| DE1768908B2 (de) | 1975-10-09 |
| FR8334M (forum.php) | 1970-12-14 |
| NL141508B (nl) | 1974-03-15 |
| NL6809956A (forum.php) | 1969-01-16 |
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