ES355205A1 - Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof - Google Patents
Novel Benzyl Alcohol Derivatives and a process for the manufacture thereofInfo
- Publication number
- ES355205A1 ES355205A1 ES355205A ES355205A ES355205A1 ES 355205 A1 ES355205 A1 ES 355205A1 ES 355205 A ES355205 A ES 355205A ES 355205 A ES355205 A ES 355205A ES 355205 A1 ES355205 A1 ES 355205A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- phch
- compounds
- benzyl alcohol
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
[alpha] - (1 - Aminoethyl) - m - methoxybenzyl alcohol, present at least partially in (-)-erythro configuration, and salts thereof are prepared by reducing a compound of the formula (R1=OH and R2 = H or R1+R2=O R3 = H, OH, PhCH 2 R4'5 = H, PhCH 2 provided that at least one of R4'5 = PhCH 2 when R1 = OH) or an acid addition salt of a compound of Formula (II), optionally followed by isolation of the erythro form, resolution and/ or salt formation, compounds of Formula (III) and compounds of Formula (II) in which R1 = OH being present at least partially in (-)-erythro configuration. The preparation of starting materials of Formul[mu] (I), (II) and (III) and of m-methoxyphenyl ethynyl carbinol and [alpha]-acetyl-m-methoxy. benzyl alcohol is described. The compounds of the invention are hypertensive agents and may be administered in the form of pharmaceutical preparations containing them, with or without other (unspecified) active ingredients, in association with a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH701468 | 1968-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES355205A1 true ES355205A1 (en) | 1969-11-16 |
Family
ID=4318578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES355205A Expired ES355205A1 (en) | 1968-05-10 | 1969-06-19 | Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE716546A (en) |
DE (1) | DE1768606A1 (en) |
ES (1) | ES355205A1 (en) |
FR (1) | FR1569369A (en) |
GB (1) | GB1187935A (en) |
IL (1) | IL30129A0 (en) |
NL (1) | NL6808601A (en) |
-
1968
- 1968-06-05 IL IL30129A patent/IL30129A0/en unknown
- 1968-06-05 DE DE19681768606 patent/DE1768606A1/en active Pending
- 1968-06-13 GB GB28149/68A patent/GB1187935A/en not_active Expired
- 1968-06-14 BE BE716546D patent/BE716546A/xx unknown
- 1968-06-19 NL NL6808601A patent/NL6808601A/xx unknown
- 1968-06-19 FR FR1569369D patent/FR1569369A/fr not_active Expired
-
1969
- 1969-06-19 ES ES355205A patent/ES355205A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE716546A (en) | 1968-12-16 |
IL30129A0 (en) | 1968-08-22 |
FR1569369A (en) | 1969-05-30 |
DE1768606A1 (en) | 1972-01-13 |
GB1187935A (en) | 1970-04-15 |
NL6808601A (en) | 1969-11-12 |
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