GB1187935A - Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof - Google Patents
Novel Benzyl Alcohol Derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1187935A GB1187935A GB28149/68A GB2814968A GB1187935A GB 1187935 A GB1187935 A GB 1187935A GB 28149/68 A GB28149/68 A GB 28149/68A GB 2814968 A GB2814968 A GB 2814968A GB 1187935 A GB1187935 A GB 1187935A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- benzyl alcohol
- phch
- compounds
- alcohol derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,187,935. Benzyl alcohol derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 13 June, 1968 [10 May, 1968], No. 28149/68. Heading C2C. α - (1 - Aminoethyl) - m - methoxybenzyl alcohol, present at least partially in (-)-erythro configuration, and salts thereof are prepared by reducing a compound of the formula (R<SP>1</SP>=OH and R<SP>2</SP> = H or R<SP>1</SP>+R<SP>2</SP>=O; R<SP>3</SP> = H, OH, PhCH 2 ; R<SP>4</SP>'<SP>5</SP> = H, PhCH 2 provided that at least one of R<SP>4</SP>'<SP>5</SP> = PhCH 2 when R<SP>1</SP> = OH) or an acid addition salt of a compound of Formula (II), optionally followed by isolation of the erythro form, resolution and/ or salt formation, compounds of Formula (III) and compounds of Formula (II) in which R<SP>1</SP> = OH being present at least partially in (-)-erythro configuration. The preparation of starting materials of Formulµ (I), (II) and (III) and of m-methoxyphenyl ethynyl carbinol and α-acetyl-m-methoxy. benzyl alcohol is described. The compounds of the invention are hypertensive agents and may be administered in the form of pharmaceutical preparations containing them, with or without other (unspecified) active ingredients, in association with a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH701468 | 1968-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1187935A true GB1187935A (en) | 1970-04-15 |
Family
ID=4318578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB28149/68A Expired GB1187935A (en) | 1968-05-10 | 1968-06-13 | Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE716546A (en) |
DE (1) | DE1768606A1 (en) |
ES (1) | ES355205A1 (en) |
FR (1) | FR1569369A (en) |
GB (1) | GB1187935A (en) |
IL (1) | IL30129A0 (en) |
NL (1) | NL6808601A (en) |
-
1968
- 1968-06-05 IL IL30129A patent/IL30129A0/en unknown
- 1968-06-05 DE DE19681768606 patent/DE1768606A1/en active Pending
- 1968-06-13 GB GB28149/68A patent/GB1187935A/en not_active Expired
- 1968-06-14 BE BE716546D patent/BE716546A/xx unknown
- 1968-06-19 NL NL6808601A patent/NL6808601A/xx unknown
- 1968-06-19 FR FR1569369D patent/FR1569369A/fr not_active Expired
-
1969
- 1969-06-19 ES ES355205A patent/ES355205A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES355205A1 (en) | 1969-11-16 |
DE1768606A1 (en) | 1972-01-13 |
FR1569369A (en) | 1969-05-30 |
IL30129A0 (en) | 1968-08-22 |
NL6808601A (en) | 1969-11-12 |
BE716546A (en) | 1968-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
48R | Reference inserted (sect. 8/1949) | ||
PLNP | Patent lapsed through nonpayment of renewal fees |