GB1187935A - Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof - Google Patents

Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof

Info

Publication number
GB1187935A
GB1187935A GB28149/68A GB2814968A GB1187935A GB 1187935 A GB1187935 A GB 1187935A GB 28149/68 A GB28149/68 A GB 28149/68A GB 2814968 A GB2814968 A GB 2814968A GB 1187935 A GB1187935 A GB 1187935A
Authority
GB
United Kingdom
Prior art keywords
formula
benzyl alcohol
phch
compounds
alcohol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28149/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1187935A publication Critical patent/GB1187935A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1,187,935. Benzyl alcohol derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 13 June, 1968 [10 May, 1968], No. 28149/68. Heading C2C. α - (1 - Aminoethyl) - m - methoxybenzyl alcohol, present at least partially in (-)-erythro configuration, and salts thereof are prepared by reducing a compound of the formula (R<SP>1</SP>=OH and R<SP>2</SP> = H or R<SP>1</SP>+R<SP>2</SP>=O; R<SP>3</SP> = H, OH, PhCH 2 ; R<SP>4</SP>'<SP>5</SP> = H, PhCH 2 provided that at least one of R<SP>4</SP>'<SP>5</SP> = PhCH 2 when R<SP>1</SP> = OH) or an acid addition salt of a compound of Formula (II), optionally followed by isolation of the erythro form, resolution and/ or salt formation, compounds of Formula (III) and compounds of Formula (II) in which R<SP>1</SP> = OH being present at least partially in (-)-erythro configuration. The preparation of starting materials of Formulµ (I), (II) and (III) and of m-methoxyphenyl ethynyl carbinol and α-acetyl-m-methoxy. benzyl alcohol is described. The compounds of the invention are hypertensive agents and may be administered in the form of pharmaceutical preparations containing them, with or without other (unspecified) active ingredients, in association with a carrier.
GB28149/68A 1968-05-10 1968-06-13 Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof Expired GB1187935A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH701468 1968-05-10

Publications (1)

Publication Number Publication Date
GB1187935A true GB1187935A (en) 1970-04-15

Family

ID=4318578

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28149/68A Expired GB1187935A (en) 1968-05-10 1968-06-13 Novel Benzyl Alcohol Derivatives and a process for the manufacture thereof

Country Status (7)

Country Link
BE (1) BE716546A (en)
DE (1) DE1768606A1 (en)
ES (1) ES355205A1 (en)
FR (1) FR1569369A (en)
GB (1) GB1187935A (en)
IL (1) IL30129A0 (en)
NL (1) NL6808601A (en)

Also Published As

Publication number Publication date
ES355205A1 (en) 1969-11-16
DE1768606A1 (en) 1972-01-13
FR1569369A (en) 1969-05-30
IL30129A0 (en) 1968-08-22
NL6808601A (en) 1969-11-12
BE716546A (en) 1968-12-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
48R Reference inserted (sect. 8/1949)
PLNP Patent lapsed through nonpayment of renewal fees