ES349217A1 - Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding) - Google Patents

Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES349217A1
ES349217A1 ES349217A ES349217A ES349217A1 ES 349217 A1 ES349217 A1 ES 349217A1 ES 349217 A ES349217 A ES 349217A ES 349217 A ES349217 A ES 349217A ES 349217 A1 ES349217 A1 ES 349217A1
Authority
ES
Spain
Prior art keywords
group
formula
lower alcohol
compound
defined above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES349217A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kefalas AS
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Kefalas AS
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR91158A external-priority patent/FR1516925A/en
Priority claimed from GB44560/67A external-priority patent/GB1215132A/en
Application filed by Kefalas AS, Commissariat a lEnergie Atomique CEA filed Critical Kefalas AS
Publication of ES349217A1 publication Critical patent/ES349217A1/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A method for the preparation of thiophthalans of the general formula: **(See formula)** where R1 and R2 are selected from the group consisting of hydrogen and lower alcohol, (see formula) is selected from the class consisting of amino, mono-lower alcohol-amino, di-lower alcohol-amino, benzyl-lower alcohol-amino, dibenzylamino, the radical of a five-membered ring saturated heterocyclic amine and the radical of a six-membered saturated ring heterocyclic amine, "alcoholic" is an alcoholic chain having 2 to 6 carbon atoms inclusive, with at least 2 carbon atoms in the chain directly connecting the ring carbon atom with the nitrogen atom, R5 is selected from the group consisting of -CO.NHR6, COOR7, -CO.R8, -CHCH.R8 and phenyl optionally substituted with a substituent selected from the group consisting of halogen, lower alcohol, alcohol- lower-oxy and trihalomethyl, in which R6 is selected from the group consisting of hydrogen, lower alcohol and phenyl optionally substituted with a substituent selected from the class consisting of lower alcohol and lower alcohol -oxy, R7 is selected from the group consisting of hydrogen and lower alcohol, and R8 is selected from the group consisting of lower alcohol, phenyl, and lower phenyl-alcohol, and X is selected from the group consisting of hydrogen, halogen, and lower alcohol., inferioroxy alcohol and trihalomethyl, comprising (a) reacting a compound of the formula: **(See formula)** where R1, R2, R5 and X are as defined above, except that R5 cannot be -COOH, with a compound of the formula: **(See formula)** where "alcoholic", R3 and R4 are as defined above and "Hal" represents chlorine, bromine or iodine, in the presence of a condensing agent, and in the case where R5'is an ester group, saponify whether is desired in order to obtain the free carboxylic acid, or (b) to react a compound of the formula **(See formula)** where R1, R2, R3, "alcoholic" and X are as defined above and U is chlorine, bromine or iodine with an amine (see formula) where R3 and R4 are as defined above, or (c) treating with hydrogen sulfide a compound of the general formula: **(See formula)** where R and R2 are hydrogen or lower alcohol groups, "alcohol", R3, R4 and X are as defined above and R5 is a phenyl group, optionally substituted by halogen, a lower alcohol group, a lower alcohol group -oxy or a trihalomethyl group, or (d) reacting a compound of the general formula **(See formula)** where R1, R2, "alcoholic" and X are as defined above, R3 is a lower alcohol group, R4 is a lower alcohol group or a benzyl group and R5 is as defined above, with the exception of -COOR7, with a chloroformic acid ester of the formula C1.COOR, in which R9 represents a lower alcohol group or a benzyl group and hydrolyze the resulting compound of the formula: **(See formula)** after which the compound of formula I obtained is isolated in the form of the free base or in the form of an acid addition salt thereof with a pharmaceutically acceptable acid, or (e) reacting a compound of the general formula: **(See formula)** where R1, R2, R3, R4, "alcoholic" and X are as defined above and R7 is a lower alcohol group, with an amine H2N.R6 or a Grignard compound R6NH.Mg.Hal, where R6 is as defined above and "Hal" is chlorine, bromine or iodine, and isolating the compound of formula I in which R5 is -CO.NHR6 in the form of the free amine or an acid addition salt thereof, or (f) reacting a compound of the general formula: **(See formula)** where R1, R2, R3, R4 "alcoholic" and X are as defined above, with a Grignard compound R8.Mg.Hal, where R8 is as defined above and "Hal" is chlorine, bromine or iodine, hydrolyze the reaction mixture with a dilute acidic solution, and isolate the compound of formula I in which R5 is -CO.R8 and, if desired, reduce this group to -CHOH.R8 in a well-known manner, and isolate the compound of formula I thus obtained in the form of the free base or of an acid addition salt thereof with a pharmaceutically acceptable acid. (Machine-translation by Google Translate, not legally binding)
ES349217A 1967-01-13 1968-01-12 Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding) Expired ES349217A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR91158A FR1516925A (en) 1967-01-13 1967-01-13 Fast electro-optical spectrometer
GB232767 1967-01-16
GB44560/67A GB1215132A (en) 1967-01-16 1967-09-29 Physiologically active amine derivatives of thiophthalane

Publications (1)

Publication Number Publication Date
ES349217A1 true ES349217A1 (en) 1971-02-16

Family

ID=27243790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES349217A Expired ES349217A1 (en) 1967-01-13 1968-01-12 Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES349217A1 (en)

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