ES349217A1 - Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding) - Google Patents
Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES349217A1 ES349217A1 ES349217A ES349217A ES349217A1 ES 349217 A1 ES349217 A1 ES 349217A1 ES 349217 A ES349217 A ES 349217A ES 349217 A ES349217 A ES 349217A ES 349217 A1 ES349217 A1 ES 349217A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- lower alcohol
- compound
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A method for the preparation of thiophthalans of the general formula: **(See formula)** where R1 and R2 are selected from the group consisting of hydrogen and lower alcohol, (see formula) is selected from the class consisting of amino, mono-lower alcohol-amino, di-lower alcohol-amino, benzyl-lower alcohol-amino, dibenzylamino, the radical of a five-membered ring saturated heterocyclic amine and the radical of a six-membered saturated ring heterocyclic amine, "alcoholic" is an alcoholic chain having 2 to 6 carbon atoms inclusive, with at least 2 carbon atoms in the chain directly connecting the ring carbon atom with the nitrogen atom, R5 is selected from the group consisting of -CO.NHR6, COOR7, -CO.R8, -CHCH.R8 and phenyl optionally substituted with a substituent selected from the group consisting of halogen, lower alcohol, alcohol- lower-oxy and trihalomethyl, in which R6 is selected from the group consisting of hydrogen, lower alcohol and phenyl optionally substituted with a substituent selected from the class consisting of lower alcohol and lower alcohol -oxy, R7 is selected from the group consisting of hydrogen and lower alcohol, and R8 is selected from the group consisting of lower alcohol, phenyl, and lower phenyl-alcohol, and X is selected from the group consisting of hydrogen, halogen, and lower alcohol., inferioroxy alcohol and trihalomethyl, comprising (a) reacting a compound of the formula: **(See formula)** where R1, R2, R5 and X are as defined above, except that R5 cannot be -COOH, with a compound of the formula: **(See formula)** where "alcoholic", R3 and R4 are as defined above and "Hal" represents chlorine, bromine or iodine, in the presence of a condensing agent, and in the case where R5'is an ester group, saponify whether is desired in order to obtain the free carboxylic acid, or (b) to react a compound of the formula **(See formula)** where R1, R2, R3, "alcoholic" and X are as defined above and U is chlorine, bromine or iodine with an amine (see formula) where R3 and R4 are as defined above, or (c) treating with hydrogen sulfide a compound of the general formula: **(See formula)** where R and R2 are hydrogen or lower alcohol groups, "alcohol", R3, R4 and X are as defined above and R5 is a phenyl group, optionally substituted by halogen, a lower alcohol group, a lower alcohol group -oxy or a trihalomethyl group, or (d) reacting a compound of the general formula **(See formula)** where R1, R2, "alcoholic" and X are as defined above, R3 is a lower alcohol group, R4 is a lower alcohol group or a benzyl group and R5 is as defined above, with the exception of -COOR7, with a chloroformic acid ester of the formula C1.COOR, in which R9 represents a lower alcohol group or a benzyl group and hydrolyze the resulting compound of the formula: **(See formula)** after which the compound of formula I obtained is isolated in the form of the free base or in the form of an acid addition salt thereof with a pharmaceutically acceptable acid, or (e) reacting a compound of the general formula: **(See formula)** where R1, R2, R3, R4, "alcoholic" and X are as defined above and R7 is a lower alcohol group, with an amine H2N.R6 or a Grignard compound R6NH.Mg.Hal, where R6 is as defined above and "Hal" is chlorine, bromine or iodine, and isolating the compound of formula I in which R5 is -CO.NHR6 in the form of the free amine or an acid addition salt thereof, or (f) reacting a compound of the general formula: **(See formula)** where R1, R2, R3, R4 "alcoholic" and X are as defined above, with a Grignard compound R8.Mg.Hal, where R8 is as defined above and "Hal" is chlorine, bromine or iodine, hydrolyze the reaction mixture with a dilute acidic solution, and isolate the compound of formula I in which R5 is -CO.R8 and, if desired, reduce this group to -CHOH.R8 in a well-known manner, and isolate the compound of formula I thus obtained in the form of the free base or of an acid addition salt thereof with a pharmaceutically acceptable acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR91158A FR1516925A (en) | 1967-01-13 | 1967-01-13 | Fast electro-optical spectrometer |
GB232767 | 1967-01-16 | ||
GB44560/67A GB1215132A (en) | 1967-01-16 | 1967-09-29 | Physiologically active amine derivatives of thiophthalane |
Publications (1)
Publication Number | Publication Date |
---|---|
ES349217A1 true ES349217A1 (en) | 1971-02-16 |
Family
ID=27243790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES349217A Expired ES349217A1 (en) | 1967-01-13 | 1968-01-12 | Electrooptic spectrometer for the obtaining of the rapid lift and with high resolution of the spectral profile of a luminous source. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES349217A1 (en) |
-
1968
- 1968-01-12 ES ES349217A patent/ES349217A1/en not_active Expired
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