ES348964A1 - Improvements in or relating to sulphanilamide derivatives - Google Patents

Improvements in or relating to sulphanilamide derivatives

Info

Publication number
ES348964A1
ES348964A1 ES348964A ES348964A ES348964A1 ES 348964 A1 ES348964 A1 ES 348964A1 ES 348964 A ES348964 A ES 348964A ES 348964 A ES348964 A ES 348964A ES 348964 A1 ES348964 A1 ES 348964A1
Authority
ES
Spain
Prior art keywords
cyclopropyl
group
methoxy
pyrimidinol
converted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES348964A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES348964A1 publication Critical patent/ES348964A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds (I) (including salts with organic and inorganic bases) wherein R 1 and R 2 signify hydrogen or cyclopropyl (one of R 1 and R 2 being cyclopropyl) and R 3 signifies an alkyl or alkoxy group, are prepared by reducing a compound related to that illustrated above wherein in place of R 1 and R 2 are the groups R1 1 and R1 2 signifying cyclopropyl or alkylthio (one of R1 1 and R1 2 being cyclopropyl), R 3 is as defined above and in place of the -NH 2 group is the group -X signifying the amino group or a nitrogencontaining group which is convertible into the amino group. 6 - Cyclopropyl - 5 - methoxy - 2 - mercapto - 4 - pyrimidinol, obtained by refluxing [alpha]-methoxy- #-oxo-cyclopropane propionic acid ethyl ester and thiourea in ethanol in the presence of sodium, is converted to 6-cyclopropyl-5 -methoxy 2 - methylthio - 4 - pyrimidinol utilizing methyl iodide and sodium hydroxide the 4-pyrimidinol is converted to the corresponding 4- chloropyrimidine by heating with phosphorus oxychloride, which in turn is converted to N1 - (6 - cyclopropyl - 5 - methoxy - 2 - methylthio- 4 - pyrimidinyl) - sulphanilamide utilizing the sodium salt of sulphanilamide in the presence of trimethylamine, dimethyl sulphoxide and dimethyl formamide. Pharmaceutical preparations suitable for the treatment of virus diseases contain as active ingredient compounds (I) administration is orally or parenterally.
ES348964A 1967-01-06 1968-01-05 Improvements in or relating to sulphanilamide derivatives Expired ES348964A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH20167A CH476739A (en) 1967-01-06 1967-01-06 Process for the preparation of new derivatives of sulfanilamide

Publications (1)

Publication Number Publication Date
ES348964A1 true ES348964A1 (en) 1969-03-16

Family

ID=4181546

Family Applications (1)

Application Number Title Priority Date Filing Date
ES348964A Expired ES348964A1 (en) 1967-01-06 1968-01-05 Improvements in or relating to sulphanilamide derivatives

Country Status (12)

Country Link
AT (1) AT275529B (en)
BE (1) BE709034A (en)
CH (1) CH476739A (en)
DE (1) DE1695106A1 (en)
DK (1) DK116593B (en)
ES (1) ES348964A1 (en)
FR (1) FR1567151A (en)
GB (1) GB1206232A (en)
NL (1) NL6800191A (en)
NO (1) NO122651B (en)
SE (1) SE339472B (en)
YU (1) YU33108B (en)

Also Published As

Publication number Publication date
NO122651B (en) 1971-07-26
YU1868A (en) 1975-10-31
FR1567151A (en) 1969-05-16
YU33108B (en) 1976-04-30
DE1695106A1 (en) 1971-04-08
AT275529B (en) 1969-10-27
GB1206232A (en) 1970-09-23
DK116593B (en) 1970-01-26
NL6800191A (en) 1968-07-08
CH476739A (en) 1969-08-15
SE339472B (en) 1971-10-11
BE709034A (en) 1968-07-05

Similar Documents

Publication Publication Date Title
GB941812A (en) Diuretic compositions
GB1154744A (en) Disubstituted Aminoethanols
ES348964A1 (en) Improvements in or relating to sulphanilamide derivatives
ES8203882A1 (en) A heterocyclic compound and its synthesis, pharmaceutical formulations thereof and the use of the compounds and the formulations in medicine.
GB1158868A (en) Novel 2,4-Disubstituted 7- and 8-Chloroquinolines, the preparation thereof and Compositions containing the same
GB1188364A (en) Quinoline Derivatives
IL40050A (en) Compositions for treating microbial infections containing piperidine derivatives
GB1322112A (en) 3,4,5-trimethoxybenzoic acid derivatives and their uses
GB1262292A (en) Novel thiazoline derivatives, the preparation thereof and compositions containing the same
GB1051388A (en)
GB1458636A (en) Methods and compositions for killing parasites of warm blooded animals
GB1231250A (en)
GB1203430A (en) Heterocyclic spiro compounds
ES338660A1 (en) 4-(2'-tetrahydrofurfuryloxy carbonyl)-phenylamino-chloro-quinolines
ES8305759A1 (en) Pyrrolidinone derivatives, their preparation and pharmaceutical compositions containing them.
GB1319197A (en) 3,4,5-trisubstituted benzoic acid derivatives and their uses
ES373657A1 (en) Di-hydro triazine derivatives and processes for their manufacture
GB1431709A (en) Lysozyme derivatives
GB1359044A (en) Quinoline derivatives
GB1168302A (en) Aluminium N-Acetylglycinate and Pharmaceutical Compositions containing the same
GB1464082A (en) Pharmaceutical 'ompositions containing benzylamines
GB1113803A (en) Improvements in or relating to substituted quinolines and the manufacture thereof
GB1188365A (en) Quinoline Derivatives
GB1225612A (en)
GB1176157A (en) Orotic Acid Salt