GB1113803A - Improvements in or relating to substituted quinolines and the manufacture thereof - Google Patents
Improvements in or relating to substituted quinolines and the manufacture thereofInfo
- Publication number
- GB1113803A GB1113803A GB5237767A GB5237767A GB1113803A GB 1113803 A GB1113803 A GB 1113803A GB 5237767 A GB5237767 A GB 5237767A GB 5237767 A GB5237767 A GB 5237767A GB 1113803 A GB1113803 A GB 1113803A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- methoxy
- pharmaceutically acceptable
- quinoline
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel 6 - methoxy - 8 - (4 - amino - 4 - methylpentylamino) -quinoline and the pharmaceutically acceptable acid addition salts thereof are prepared by condensation of 1-bromo-4-methyl-4-nitro - pentane with 6 - methoxy - 8 - aminoquinoline, followed by hydrogenation of the resulting 6 - methoxy - 8 - (4 - methyl - 4 - nitropentylamino) - quinoline monohydrobromide and optional conversion of the product to a pharmaceutically acceptable acid addition salt thereof. Pharmaceutical compositions, having anti-inflammatory and anti-amebic activity and being useful in the treatment of malarial infections, comprise 6 - methoxy - 8 - (4 - amino 4 - methyl - pentylamino) - quinoline or a pharmaceutically acceptable acid addition salt thereof as active ingredient, together with a pharmaceutically acceptable carrier. 1 - Bromo - 4 - methyl - 4 - nitropentane is prepared by reduction of ethyl 4-methyl-4-nitrovalerate, followed by treatment of the resulting 4 - methyl - 4 - nitro - 1 - pentanol with phosphorus tribromide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37181164A | 1964-06-01 | 1964-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1113803A true GB1113803A (en) | 1968-05-15 |
Family
ID=23465490
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2165565A Expired GB1113802A (en) | 1964-06-01 | 1965-05-21 | Improvements in or relating to substituted quinolines and the manufacture thereof |
GB5237767A Expired GB1113803A (en) | 1964-06-01 | 1965-05-21 | Improvements in or relating to substituted quinolines and the manufacture thereof |
GB5237867A Expired GB1113804A (en) | 1964-06-01 | 1965-05-21 | Improvements in or relating to substituted quinolines and the manufacture thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2165565A Expired GB1113802A (en) | 1964-06-01 | 1965-05-21 | Improvements in or relating to substituted quinolines and the manufacture thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5237867A Expired GB1113804A (en) | 1964-06-01 | 1965-05-21 | Improvements in or relating to substituted quinolines and the manufacture thereof |
Country Status (4)
Country | Link |
---|---|
DE (2) | DE1620228A1 (en) |
GB (3) | GB1113802A (en) |
IL (1) | IL23555A (en) |
NL (1) | NL6506950A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020042537A1 (en) * | 2000-07-13 | 2002-04-11 | Ajinomoto Co., Inc. | Method for producing lysine derivative |
CA2521619A1 (en) * | 2003-04-11 | 2004-10-28 | Taigen Biotechnology | Aminoquinoline compounds |
DE102010048476A1 (en) * | 2010-10-14 | 2012-08-23 | Julius-Maximilians-Universität Würzburg | Hybrid compounds of 4- and 8-aminoquinolines for the prophylactic and therapeutic treatment of malaria and other parasitic diseases |
-
1965
- 1965-05-17 IL IL2355565A patent/IL23555A/en unknown
- 1965-05-21 GB GB2165565A patent/GB1113802A/en not_active Expired
- 1965-05-21 GB GB5237767A patent/GB1113803A/en not_active Expired
- 1965-05-21 GB GB5237867A patent/GB1113804A/en not_active Expired
- 1965-05-31 DE DE19651620228 patent/DE1620228A1/en active Pending
- 1965-05-31 DE DE19651620229 patent/DE1620229A1/en active Pending
- 1965-06-01 NL NL6506950A patent/NL6506950A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE1620228A1 (en) | 1970-06-04 |
NL6506950A (en) | 1965-12-02 |
DE1620229A1 (en) | 1970-06-04 |
IL23555A (en) | 1969-05-28 |
GB1113804A (en) | 1968-05-15 |
GB1113802A (en) | 1968-05-15 |
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