ES348557A1 - Novel Secondary Amines and a Process for the Manufacture thereof - Google Patents
Novel Secondary Amines and a Process for the Manufacture thereofInfo
- Publication number
- ES348557A1 ES348557A1 ES348557A ES348557A ES348557A1 ES 348557 A1 ES348557 A1 ES 348557A1 ES 348557 A ES348557 A ES 348557A ES 348557 A ES348557 A ES 348557A ES 348557 A1 ES348557 A1 ES 348557A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- lower alkyl
- optionally
- choh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Racemic and optically active compounds of the general Formula (I) (A = CH 2 , CHOH, CO R1 = lower alkyl, alkenyl, alkynyl R2 = allyl, propargyl, cyclopropylmethyl, each optionally lower alkylsubstituted) and their acid addition salts are prepared by (a) reducing a compound of the Formula (II) (A1 = CH 2 ) (b) reacting a compound of the Formula (III) with R2X (X = halogen) (c) reacting a compound of the Formula (V) with H2NH 2 or (d) reducing a compound of the Formula VII) (R3 = cyclopropyl, optionally lower alkyl-substituted), optionally followed by reduction of CO to CHOH, salt formation and/or resolution. The lower alkyl groups contain 1-7 carbon atoms, and the lower alkenyl and alkynyl groups contain up to 6 carbon atoms. The preparation of starting materials of Formul[mu] (II), (III), (V) and (VII) and of 3 - allyloxyphenylacetone, 3 - propargyloxyphenylacetone, 3 - propargyloxybenzaldehyde, 31- methoxy - 2 - phthalimidopropiophenone and 2- amino - 31- methoxypropiophenone hydrochloride is described. The compounds of the invention are hypertensive agents and may be administered in the form of pharmaceutical preparations containing them, with or without other (unspecified) active ingredients, in association with an excipient or carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1848766A CH481876A (en) | 1966-12-23 | 1966-12-23 | Process for the preparation of secondary amines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES348557A1 true ES348557A1 (en) | 1969-03-16 |
Family
ID=4433295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES348557A Expired ES348557A1 (en) | 1966-12-23 | 1967-12-22 | Novel Secondary Amines and a Process for the Manufacture thereof |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE708248A (en) |
CH (1) | CH481876A (en) |
ES (1) | ES348557A1 (en) |
FR (2) | FR7817M (en) |
GB (1) | GB1170348A (en) |
GR (1) | GR37789B (en) |
NL (1) | NL6714636A (en) |
-
1966
- 1966-12-23 CH CH1848766A patent/CH481876A/en not_active IP Right Cessation
-
1967
- 1967-10-27 NL NL6714636A patent/NL6714636A/xx unknown
- 1967-12-20 BE BE708248D patent/BE708248A/xx unknown
- 1967-12-20 GB GB5779167A patent/GB1170348A/en not_active Expired
- 1967-12-21 GR GR670137789A patent/GR37789B/en unknown
- 1967-12-22 FR FR133494A patent/FR7817M/fr not_active Expired
- 1967-12-22 FR FR1549030D patent/FR1549030A/fr not_active Expired
- 1967-12-22 ES ES348557A patent/ES348557A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR7817M (en) | 1970-05-20 |
CH481876A (en) | 1969-11-30 |
BE708248A (en) | 1968-06-20 |
FR1549030A (en) | 1968-12-06 |
GB1170348A (en) | 1969-11-12 |
NL6714636A (en) | 1968-06-24 |
GR37789B (en) | 1969-07-15 |
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