ES343930A1 - Procedimiento para producir nuevos analogos de prestaglan- dina e1 y prostablandina f1. - Google Patents
Procedimiento para producir nuevos analogos de prestaglan- dina e1 y prostablandina f1.Info
- Publication number
- ES343930A1 ES343930A1 ES343930A ES343930A ES343930A1 ES 343930 A1 ES343930 A1 ES 343930A1 ES 343930 A ES343930 A ES 343930A ES 343930 A ES343930 A ES 343930A ES 343930 A1 ES343930 A1 ES 343930A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- compounds
- alkyl
- racemates
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 2
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000000376 reactant Substances 0.000 abstract 3
- 101000692460 Bos taurus Prostaglandin F synthase 1 Proteins 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- DZUXGQBLFALXCR-UHFFFAOYSA-N (+)-(9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprost-13-en-1-oic acid Natural products CCCCCC(O)C=CC1C(O)CC(O)C1CCCCCCC(O)=O DZUXGQBLFALXCR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- SCKXCAADGDQQCS-UHFFFAOYSA-N Performic acid Chemical compound OOC=O SCKXCAADGDQQCS-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011946 reduction process Methods 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3555066 | 1966-08-09 | ||
| GB3588/67A GB1198071A (en) | 1966-08-09 | 1967-01-24 | Improvements in or relating to Prostaglandin Analogues and the Manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES343930A1 true ES343930A1 (es) | 1969-02-16 |
Family
ID=26238450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES343930A Expired ES343930A1 (es) | 1966-08-09 | 1967-08-08 | Procedimiento para producir nuevos analogos de prestaglan- dina e1 y prostablandina f1. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US3784634A (es) |
| JP (1) | JPS4948430B1 (es) |
| BE (1) | BE702477A (es) |
| CH (2) | CH529085A (es) |
| DE (1) | DE1668257A1 (es) |
| DK (1) | DK131426B (es) |
| ES (1) | ES343930A1 (es) |
| FI (1) | FI51476C (es) |
| FR (1) | FR1533808A (es) |
| GB (1) | GB1198071A (es) |
| GR (1) | GR36065B (es) |
| IL (1) | IL28412A (es) |
| NO (1) | NO127862B (es) |
| PH (3) | PH9543A (es) |
| SE (2) | SE362068B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1191412A (en) * | 1968-01-17 | 1970-05-13 | May & Baker Ltd | Aerosols and Compositions containing Prostaglandin Compounds |
| IL32518A (en) * | 1968-07-29 | 1974-03-14 | Upjohn Co | Prostaglandins and analogs thereof |
| IL32553A0 (en) * | 1968-07-29 | 1969-09-25 | Upjohn Co | Prostaglandins and analogs thereof |
| IL32622A0 (en) * | 1968-07-29 | 1969-09-25 | Upjohn Co | Prostaglandins and analogs thereof |
| GB1269659A (en) * | 1968-07-29 | 1972-04-06 | Upjohn Co | Improvements in or relating to prostaglandins and the manufacture thereof |
| IL32621A (en) * | 1968-07-29 | 1973-05-31 | Upjohn Co | Prostaglandins and analogs thereof |
| IL32624A0 (en) * | 1968-07-29 | 1969-09-25 | Upjohn Co | Prostaglandins and analogs thereof |
| IL32552A (en) * | 1968-07-29 | 1975-07-28 | Upjohn Co | Prostaglandin analogs |
| GB1285371A (en) * | 1968-08-29 | 1972-08-16 | Upjohn Co | Improvements in or relating to therapeutic methods using prostaglandins |
| GB1251750A (es) * | 1968-11-12 | 1971-10-27 | ||
| CA927393A (en) * | 1970-03-09 | 1973-05-29 | The Upjohn Company | Cyclopentane derivatives |
| JPS5114505B1 (es) * | 1970-04-15 | 1976-05-10 | ||
| FR2085654B1 (es) * | 1970-04-30 | 1973-06-08 | Roussel Uclaf | |
| US3728382A (en) * | 1970-05-04 | 1973-04-17 | Upjohn Co | 15-methyl and 15-ethyl prostaglandin analogs |
| US3671570A (en) * | 1970-07-30 | 1972-06-20 | Ayerst Mckenna & Harrison | Derivatives of 9-oxo-15-hydroxyprostanoic acid, homologs thereof and their preparation |
| DE2422498A1 (de) * | 1973-05-18 | 1974-12-05 | Ciba Geigy Ag | Neue thiaprostaglandine und verfahren zu ihrer herstellung |
| DE2328132A1 (de) * | 1973-05-30 | 1975-01-02 | Schering Ag | Neue prostansaeurederivate und verfahren zu ihrer herstellung |
-
1967
- 1967-01-24 GB GB3588/67A patent/GB1198071A/en not_active Expired
- 1967-07-28 GR GR670136065A patent/GR36065B/el unknown
- 1967-07-28 IL IL28412A patent/IL28412A/en unknown
- 1967-08-03 CH CH1098667A patent/CH529085A/de not_active IP Right Cessation
- 1967-08-03 CH CH1425871A patent/CH529091A/de not_active IP Right Cessation
- 1967-08-08 FR FR117266A patent/FR1533808A/fr not_active Expired
- 1967-08-08 SE SE11264/67A patent/SE362068B/xx unknown
- 1967-08-08 DK DK404567AA patent/DK131426B/da unknown
- 1967-08-08 SE SE7200762*3A patent/SE383878B/xx unknown
- 1967-08-08 ES ES343930A patent/ES343930A1/es not_active Expired
- 1967-08-08 DE DE19671668257 patent/DE1668257A1/de active Pending
- 1967-08-08 NO NO67169291A patent/NO127862B/no unknown
- 1967-08-09 PH PH8478*UA patent/PH9543A/en unknown
- 1967-08-09 BE BE702477A patent/BE702477A/xx unknown
- 1967-08-09 FI FI672151A patent/FI51476C/fi active
-
1969
- 1969-08-04 JP JP44061114A patent/JPS4948430B1/ja active Pending
-
1970
- 1970-12-31 US US00103315A patent/US3784634A/en not_active Expired - Lifetime
-
1972
- 1972-01-12 PH PH13182*UA patent/PH9694A/en unknown
- 1972-01-12 PH PH13185*A patent/PH9788A/en unknown
- 1972-08-17 US US00281338A patent/US3816508A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI51476C (fi) | 1977-01-10 |
| DK131426B (da) | 1975-07-14 |
| DE1668257A1 (de) | 1971-09-16 |
| PH9694A (en) | 1976-02-19 |
| GR36065B (el) | 1968-12-11 |
| DK131426C (es) | 1975-12-01 |
| CH529091A (de) | 1972-10-15 |
| SE383878B (sv) | 1976-04-05 |
| FI51476B (es) | 1976-09-30 |
| PH9543A (en) | 1976-01-09 |
| US3784634A (en) | 1974-01-08 |
| BE702477A (es) | 1968-02-09 |
| IL28412A (en) | 1972-09-28 |
| PH9788A (en) | 1976-03-17 |
| GB1198071A (en) | 1970-07-08 |
| US3816508A (en) | 1974-06-11 |
| CH529085A (de) | 1972-10-15 |
| FR1533808A (fr) | 1968-07-19 |
| NO127862B (es) | 1973-08-27 |
| SE362068B (es) | 1973-11-26 |
| JPS4948430B1 (es) | 1974-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES343930A1 (es) | Procedimiento para producir nuevos analogos de prestaglan- dina e1 y prostablandina f1. | |
| US3795697A (en) | Pge2 esters and alkanoates | |
| US3919285A (en) | PGE{HD 3 {B analogs | |
| IL41515A (en) | 11-deoxyprostaglandin derivatives and their preparation | |
| GB1226937A (es) | ||
| ES358955A1 (es) | Procedimiento para la produccion de nuevos compuestos orga-nicos relacionados estructuralmente con las prostaglandinas. | |
| US3847967A (en) | 15-lower alkoxy pgb compounds | |
| GB1364082A (en) | Esters of tricyclic piperazinoalkanols and the mthod od producing them | |
| US3845115A (en) | 15-lower alkoxy pgf compounds | |
| GB1424417A (en) | Prostaglandin intermediates and their preparation | |
| US3812179A (en) | 15-methyl and ethyl pge2 | |
| CA1093069A (en) | Cyclopentane derivatives | |
| US3903131A (en) | 16 and 16,16-dimethyl PGE{HD 2{B | |
| US3904679A (en) | 15-Methyl and 15-ethyl prostaglandin F{HD 2{331 {0 {B analogs | |
| US3923861A (en) | 3-Oxa prostaglandin F{331 -type compounds | |
| US3922293A (en) | Prostaglandin F-type 9-monoacylates | |
| US3849487A (en) | Natural 15-methyl and ethyl-15-epi-pge1 | |
| US3781325A (en) | 15-methoxy-pgf2a | |
| GB1183841A (en) | Prostaglandin Related Compounds | |
| GB1434620A (en) | Prostaglandins and the preparation thereof | |
| US3853963A (en) | Prastaglandin f type 9-monoacylates | |
| US3835180A (en) | 15 alkoxy pge compounds | |
| US3883576A (en) | Prostaglandin E{HD 3 {B analogs | |
| US3855270A (en) | 15-alkyl prostaglandins f{11 {301 | |
| US3770788A (en) | Silvated prostaglandins and process therefor |