ES336869A1 - Procedimiento para la preparacion de 3,4-cis-4-ail-isofla- vanos. - Google Patents
Procedimiento para la preparacion de 3,4-cis-4-ail-isofla- vanos.Info
- Publication number
- ES336869A1 ES336869A1 ES336869A ES336869A ES336869A1 ES 336869 A1 ES336869 A1 ES 336869A1 ES 336869 A ES336869 A ES 336869A ES 336869 A ES336869 A ES 336869A ES 336869 A1 ES336869 A1 ES 336869A1
- Authority
- ES
- Spain
- Prior art keywords
- atoms
- oestrogenic
- alkoxy
- novel compounds
- alkyl containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- CNNBJLXLTIKXGJ-UHFFFAOYSA-N 3-phenyl-2h-chromene Chemical class C1OC2=CC=CC=C2C=C1C1=CC=CC=C1 CNNBJLXLTIKXGJ-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 229910004727 OSO3H Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 230000003509 anti-fertility effect Effects 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM0068414 | 1966-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES336869A1 true ES336869A1 (es) | 1968-05-01 |
Family
ID=7312594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES336869A Expired ES336869A1 (es) | 1966-02-16 | 1967-02-15 | Procedimiento para la preparacion de 3,4-cis-4-ail-isofla- vanos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3535344A (enExample) |
| BE (1) | BE694025A (enExample) |
| CH (1) | CH494222A (enExample) |
| DE (1) | DE1543749A1 (enExample) |
| DK (1) | DK118611B (enExample) |
| ES (1) | ES336869A1 (enExample) |
| FR (1) | FR6192M (enExample) |
| GB (1) | GB1103094A (enExample) |
| IL (1) | IL27321A (enExample) |
| NL (1) | NL6702140A (enExample) |
| SE (1) | SE328301B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053626A (en) * | 1973-03-13 | 1977-10-11 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Cholesterol level-lowering phenoxyacetic acids |
| USRE40792E1 (en) * | 1992-05-19 | 2009-06-23 | Novogen Research Pty Ltd | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
| US5446061A (en) * | 1993-11-05 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
| US5407955A (en) * | 1994-02-18 | 1995-04-18 | Eli Lilly And Company | Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease |
| US5446071A (en) * | 1994-11-18 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
| CZ212397A3 (en) * | 1995-01-13 | 1997-11-12 | Novo Nordisk As | Use of 3,4-diphenylchromans for preparing pharmaceutical preparations for treating or prophylaxis of hyperlipoproteinaemia, hypertriacylglycerolaemia, hyperlipidaemia, hypercholesterolaemia, arteriosclerosis and reduction of blood sedimentation |
| BE1010487A6 (nl) | 1996-06-11 | 1998-10-06 | Unilin Beheer Bv | Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen. |
| AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| CA2270111A1 (en) * | 1996-10-28 | 1998-05-07 | Lise Brown Christiansen | Novel (-)-enantiomers of cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| ES2188909T3 (es) * | 1996-10-28 | 2003-07-01 | Novo Nordisk As | Nuevos derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes o enfermedades relacionados con el estrogeno. os |
| US6043269A (en) * | 1996-10-28 | 2000-03-28 | Novo Nordisk A/S | cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| JP2001502708A (ja) * | 1996-10-28 | 2001-02-27 | ノボ ノルディスク アクティーゼルスカブ | エストロゲン関連の疾患または症候群の予防または治療に有用な新規なシス―３，４―クロマン誘導体 |
| JP2002503213A (ja) * | 1996-10-28 | 2002-01-29 | ノボ ノルディスク アクティーゼルスカブ | エストロゲン関連疾患または症候群の防止または治療に有用な新規なｃｉｓ―３，４―クロマン誘導体 |
| EP0937059A1 (en) * | 1996-10-28 | 1999-08-25 | Novo Nordisk A/S | NOVEL $i(TRANS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES |
| US6316494B1 (en) | 1996-10-28 | 2001-11-13 | Novo Nordisk A/S | cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| US5985306A (en) * | 1996-10-28 | 1999-11-16 | Novo Nordisk A/S | (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes |
| EP0937058A1 (en) * | 1996-10-28 | 1999-08-25 | Novo Nordisk A/S | NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES |
| US5919817A (en) * | 1996-10-28 | 1999-07-06 | Novo Nordisk A/S | Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| US5958967A (en) * | 1996-10-28 | 1999-09-28 | Novo Nordisk A/S | Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| AU4772197A (en) * | 1996-10-28 | 1998-05-22 | Novo Nordisk A/S | Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| ZA979644B (en) * | 1996-10-28 | 1998-04-28 | Novo Nordisk As | Heterocyclic compounds, compositions and uses. |
| IL129618A0 (en) * | 1996-10-28 | 2000-02-29 | Novo Nordisk As | Novel CIS-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| US5994390A (en) * | 1996-10-28 | 1999-11-30 | Novo Nordisk | Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| US6146668A (en) | 1997-04-28 | 2000-11-14 | Novogen, Inc. | Preparation of isoflavones from legumes |
| US6340703B1 (en) * | 1997-05-01 | 2002-01-22 | Novogen, Inc. | Treatment or prevention of osteoporosis |
| AUPP112497A0 (en) * | 1997-12-24 | 1998-01-22 | Novogen Research Pty Ltd | Compositions and method for protecting skin from UV induced immunosupression and skin damage |
| AUPP260798A0 (en) | 1998-03-26 | 1998-04-23 | Novogen Research Pty Ltd | Treatment of medical related conditions with isoflavone containing extracts of clover |
| KR20000001793A (ko) | 1998-06-13 | 2000-01-15 | 이경하 | 신규한 벤조피란 또는 티오벤조피란 유도체 |
| AUPP868599A0 (en) * | 1999-02-15 | 1999-03-11 | Novogen Research Pty Ltd | Production of isoflavone derivatives |
| AUPQ266199A0 (en) * | 1999-09-06 | 1999-09-30 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| US20090233999A1 (en) * | 1999-09-06 | 2009-09-17 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPQ520300A0 (en) * | 2000-01-21 | 2000-02-17 | Novogen Research Pty Ltd | Food product and process |
| US7214706B2 (en) | 2000-03-01 | 2007-05-08 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
| AUPR363301A0 (en) * | 2001-03-08 | 2001-04-05 | Novogen Research Pty Ltd | Dimeric isoflavones |
| US20050119301A1 (en) * | 2001-03-16 | 2005-06-02 | Alan Husband | Treatment of restenosis |
| WO2005049627A1 (en) * | 2003-11-18 | 2005-06-02 | Novogen Research Pty Ltd | Isoflavonoid prodrugs, compositions thereof and therapeutic methods involving same |
| AU2004290613B2 (en) * | 2003-11-18 | 2010-03-25 | Novogen Research Pty Ltd | Isoflavonoid prodrugs, compositions thereof and therapeutic methods involving same |
| US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| ATE532777T1 (de) | 2004-09-21 | 2011-11-15 | Marshall Edwards Inc | Substituierte chromanderivate, medikamente und anwendungen in der therapie |
| CA2816322A1 (en) | 2010-11-01 | 2012-05-10 | Marshall Edwards, Inc. | Isoflavonoid compositions and methods for the treatment of cancer |
| CN107427003B (zh) | 2015-02-02 | 2023-01-31 | 梅制药公司 | 联合治疗 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3340276A (en) * | 1964-04-01 | 1967-09-05 | Ciba Geigy Corp | 3, 4-diphenyl-chromans |
| CH471113A (de) * | 1965-01-29 | 1969-04-15 | Merck Ag E | Verfahren zur Herstellung von wasserlöslichen Flavanoidderivaten |
| US3436393A (en) * | 1965-12-27 | 1969-04-01 | Parke Davis & Co | 4'-methoxy-2,2,4-trialkyl-delta**3-isoflavan compounds |
-
1966
- 1966-02-16 DE DE19661543749 patent/DE1543749A1/de active Pending
-
1967
- 1967-01-18 CH CH73167A patent/CH494222A/de not_active IP Right Cessation
- 1967-01-20 GB GB3175/67A patent/GB1103094A/en not_active Expired
- 1967-01-25 IL IL27321A patent/IL27321A/en unknown
- 1967-02-13 BE BE694025D patent/BE694025A/xx unknown
- 1967-02-13 FR FR94664A patent/FR6192M/fr not_active Expired
- 1967-02-13 NL NL6702140A patent/NL6702140A/xx unknown
- 1967-02-13 US US615391A patent/US3535344A/en not_active Expired - Lifetime
- 1967-02-14 DK DK80167AA patent/DK118611B/da unknown
- 1967-02-15 SE SE02111/67A patent/SE328301B/xx unknown
- 1967-02-15 ES ES336869A patent/ES336869A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3535344A (en) | 1970-10-20 |
| CH494222A (de) | 1970-07-31 |
| DE1543749A1 (de) | 1969-12-11 |
| BE694025A (enExample) | 1967-08-14 |
| IL27321A (en) | 1970-09-17 |
| NL6702140A (enExample) | 1967-08-17 |
| GB1103094A (en) | 1968-02-14 |
| DK118611B (da) | 1970-09-14 |
| SE328301B (enExample) | 1970-09-14 |
| FR6192M (enExample) | 1968-07-22 |
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