ES336777A1 - Piperazine derivatives and preparation thereof - Google Patents

Piperazine derivatives and preparation thereof

Info

Publication number
ES336777A1
ES336777A1 ES336777A ES336777A ES336777A1 ES 336777 A1 ES336777 A1 ES 336777A1 ES 336777 A ES336777 A ES 336777A ES 336777 A ES336777 A ES 336777A ES 336777 A1 ES336777 A1 ES 336777A1
Authority
ES
Spain
Prior art keywords
amidoxime
fluorophenyl
chlorobutyryl
thienyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES336777A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of ES336777A1 publication Critical patent/ES336777A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel piperazine derivatives (and acid addition salts) of the formula <FORM:1110360/C2/1> wherein R1 is a phenyl, 4-fluorophenyl, 3,4,5-trimethoxyphenyl, furyl, thienyl, 3- or 4-pyridyl group R2 is a phenyl, 4-chlorophenyl, 2- or 4-fluorophenyl, a phenyl-alkoxyethyl group C6H5.CHOR.CH2- (in which R is an alkyl group having up to 4 carbons) or a benzyl group and n is 1, 2 or 3, are prepared (a) by the interaction of the appropriate 5-chloroalkyl-1,2,4-oxadiazole, also containing the desired 3-substituent, and the appropriately 1-substituted piperazine or (b) for compounds in which n is 2 the starting materials may be an acrylylamidoxime of formula CH2=CH.C:O(ON:CR1-NH2) and the 1-substituted piperazine. Pharmaceutical compositions having anti-inflammatory and analgesic properties contain as the active ingredient the above novel compounds and are administered intravenously. Acrylyl - 4 - fluorophenyl - amidoxime is prepared by the interaction of 4-fluorophenyl-amidoxime and acrylic acid chloride. 3 - Chlorobutyryl - 2 - thienyl amidoxime is prepared by the interaction of 2-thienyl amidoxime and g -chlorobutyryl chloride and 3-chlorobutyryl - 2 - furyl-, and 3 - chlorobutyryl-3-(and 4-)pyridyl-amidoximes are similarly obtained. These amidoximes are cyclized to form the corresponding 1,2,4-oxadiazole precursors.
ES336777A 1966-02-16 1967-02-13 Piperazine derivatives and preparation thereof Expired ES336777A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MC608A MC598A1 (en) 1966-02-16 1966-02-16 New chemical compounds and process for their preparation

Publications (1)

Publication Number Publication Date
ES336777A1 true ES336777A1 (en) 1968-06-01

Family

ID=19737671

Family Applications (1)

Application Number Title Priority Date Filing Date
ES336777A Expired ES336777A1 (en) 1966-02-16 1967-02-13 Piperazine derivatives and preparation thereof

Country Status (7)

Country Link
CH (1) CH478141A (en)
DE (1) DE1695392A1 (en)
ES (1) ES336777A1 (en)
FR (1) FR6671M (en)
GB (1) GB1110360A (en)
MC (1) MC598A1 (en)
NL (1) NL6702283A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3005287A1 (en) * 1980-02-13 1981-08-20 Basf Ag, 6700 Ludwigshafen PHENYLPIPERAZINE DERIVATIVES OF 1,3,4-OXADIAZOLYLPHENOLS, THEIR PRODUCTION AND THERAPEUTIC AGENTS CONTAINING THEM
JP4881725B2 (en) * 2003-04-09 2012-02-22 エクセリクシス， インク． TIE-2 modulator and usage
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
DE102005061427A1 (en) * 2005-12-22 2007-06-28 Grünenthal GmbH New 1-aminomethyl-4-oxadiazolylalkyl-cyclohexane derivatives, useful for treating e.g. pain, depression and urinary incontinence, bind to mu-opioid receptors and inhibit reuptake of serotonin and noradrenaline

Also Published As

Publication number Publication date
NL6702283A (en) 1967-08-17
GB1110360A (en) 1968-04-18
DE1695392A1 (en) 1971-04-08
FR6671M (en) 1969-02-03
CH478141A (en) 1969-09-15
MC598A1 (en) 1967-03-21

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