ES336777A1 - Piperazine derivatives and preparation thereof - Google Patents
Piperazine derivatives and preparation thereofInfo
- Publication number
- ES336777A1 ES336777A1 ES336777A ES336777A ES336777A1 ES 336777 A1 ES336777 A1 ES 336777A1 ES 336777 A ES336777 A ES 336777A ES 336777 A ES336777 A ES 336777A ES 336777 A1 ES336777 A1 ES 336777A1
- Authority
- ES
- Spain
- Prior art keywords
- amidoxime
- fluorophenyl
- chlorobutyryl
- thienyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel piperazine derivatives (and acid addition salts) of the formula <FORM:1110360/C2/1> wherein R1 is a phenyl, 4-fluorophenyl, 3,4,5-trimethoxyphenyl, furyl, thienyl, 3- or 4-pyridyl group R2 is a phenyl, 4-chlorophenyl, 2- or 4-fluorophenyl, a phenyl-alkoxyethyl group C6H5.CHOR.CH2- (in which R is an alkyl group having up to 4 carbons) or a benzyl group and n is 1, 2 or 3, are prepared (a) by the interaction of the appropriate 5-chloroalkyl-1,2,4-oxadiazole, also containing the desired 3-substituent, and the appropriately 1-substituted piperazine or (b) for compounds in which n is 2 the starting materials may be an acrylylamidoxime of formula CH2=CH.C:O(ON:CR1-NH2) and the 1-substituted piperazine. Pharmaceutical compositions having anti-inflammatory and analgesic properties contain as the active ingredient the above novel compounds and are administered intravenously. Acrylyl - 4 - fluorophenyl - amidoxime is prepared by the interaction of 4-fluorophenyl-amidoxime and acrylic acid chloride. 3 - Chlorobutyryl - 2 - thienyl amidoxime is prepared by the interaction of 2-thienyl amidoxime and g -chlorobutyryl chloride and 3-chlorobutyryl - 2 - furyl-, and 3 - chlorobutyryl-3-(and 4-)pyridyl-amidoximes are similarly obtained. These amidoximes are cyclized to form the corresponding 1,2,4-oxadiazole precursors.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MC608A MC598A1 (en) | 1966-02-16 | 1966-02-16 | New chemical compounds and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES336777A1 true ES336777A1 (en) | 1968-06-01 |
Family
ID=19737671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES336777A Expired ES336777A1 (en) | 1966-02-16 | 1967-02-13 | Piperazine derivatives and preparation thereof |
Country Status (7)
Country | Link |
---|---|
CH (1) | CH478141A (en) |
DE (1) | DE1695392A1 (en) |
ES (1) | ES336777A1 (en) |
FR (1) | FR6671M (en) |
GB (1) | GB1110360A (en) |
MC (1) | MC598A1 (en) |
NL (1) | NL6702283A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3005287A1 (en) * | 1980-02-13 | 1981-08-20 | Basf Ag, 6700 Ludwigshafen | PHENYLPIPERAZINE DERIVATIVES OF 1,3,4-OXADIAZOLYLPHENOLS, THEIR PRODUCTION AND THERAPEUTIC AGENTS CONTAINING THEM |
EP1611123B8 (en) | 2003-04-09 | 2013-11-13 | Exelixis, Inc. | Tie-2 modulators and methods of use |
GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
DE102005061427A1 (en) * | 2005-12-22 | 2007-06-28 | GrĂ¼nenthal GmbH | New 1-aminomethyl-4-oxadiazolylalkyl-cyclohexane derivatives, useful for treating e.g. pain, depression and urinary incontinence, bind to mu-opioid receptors and inhibit reuptake of serotonin and noradrenaline |
-
1966
- 1966-02-16 MC MC608A patent/MC598A1/en unknown
-
1967
- 1967-01-27 FR FR92738A patent/FR6671M/fr not_active Expired
- 1967-02-06 GB GB5586/67A patent/GB1110360A/en not_active Expired
- 1967-02-07 CH CH182267A patent/CH478141A/en not_active IP Right Cessation
- 1967-02-10 DE DE19671695392 patent/DE1695392A1/en active Pending
- 1967-02-13 ES ES336777A patent/ES336777A1/en not_active Expired
- 1967-02-15 NL NL6702283A patent/NL6702283A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MC598A1 (en) | 1967-03-21 |
CH478141A (en) | 1969-09-15 |
GB1110360A (en) | 1968-04-18 |
NL6702283A (en) | 1967-08-17 |
DE1695392A1 (en) | 1971-04-08 |
FR6671M (en) | 1969-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3587568D1 (en) | Pharmaceutical compositions containing diazepines with platelet activating factor (PAF) antagonistic action. | |
ES425626A1 (en) | Acylxylidide local anaesthetics | |
ES382427A1 (en) | Styrene derivatives | |
ES336777A1 (en) | Piperazine derivatives and preparation thereof | |
GB1174411A (en) | Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture | |
ES446993A1 (en) | Pharmaceutical formulations containing hydrocy bezophenonederivatives | |
ES453162A1 (en) | 6-Oxa-1-aza tricyclo dodecan-5-ones as psychomotor stimulators | |
ES341733A1 (en) | 5-((aryldehydropiperidinyl- and aryldehydropyrrolidinyl) - lower - alkyl) - 2-oxazolidinones | |
GB1306558A (en) | Derivatives of thiazolino-pyrimidin-5-ones their preparation and applications | |
NO141759C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PENICILLINES | |
ES481855A1 (en) | 6-Methoxy-2-acethylnaphthalene oximes | |
GB1106861A (en) | 4-arylpyridines, their acid addition salts, and processes for the preparation thereof | |
GB1297035A (en) | ||
GB1384523A (en) | Oxime derivatives and their preparation | |
GB1470493A (en) | Anti-hypertensive 4-1-2-naphthyl-methyl-1,2,5,6-tetrahydro pyrid-4-yl-chroman-5-ol esters | |
ES363591A1 (en) | beta-PHENETHYLAMINE DERIVATIVES AND A PROCESS FOR THE MANUFACTURE THEREOF | |
ES369646A1 (en) | A procedure for the preparation of the derivatives of 5-thzolol carboxylic acid. (Machine-translation by Google Translate, not legally binding) | |
GB1184329A (en) | 4-(2-Carboxy-1-Benzalimino)-1,5-Dimethyl-2-Phenyl-3-Pyrazolone, Organic and Inorganic Derivatives Thereof and Process for Producing the Same | |
IE39639B1 (en) | N-substituted cycloserine compounds | |
GB1518722A (en) | Pharmaceutical composition containing cephalosporin compounds | |
ES361590A1 (en) | Esters of alpha-(1-substituted-3-pyrrolidinyl)-alpha-phenyl acetic acid | |
ES357983A1 (en) | Novel quinazoline compounds and process means for producing the same | |
IL45174A (en) | Antibacterial compositions containing 3-fluoro-d-alanine type compound and n-substituted cycloserine compound | |
ES368730A1 (en) | Benzodioxole compounds | |
GB1090545A (en) | Disubstituted isoxazole derivatives and non-toxic salts thereof |