ES3072651T3 - Scalable synthesis of reduced toxicity derivative of amphotericin b - Google Patents

Scalable synthesis of reduced toxicity derivative of amphotericin b

Info

Publication number
ES3072651T3
ES3072651T3 ES15851160T ES15851160T ES3072651T3 ES 3072651 T3 ES3072651 T3 ES 3072651T3 ES 15851160 T ES15851160 T ES 15851160T ES 15851160 T ES15851160 T ES 15851160T ES 3072651 T3 ES3072651 T3 ES 3072651T3
Authority
ES
Spain
Prior art keywords
certain variants
solvent
substituted
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15851160T
Other languages
English (en)
Spanish (es)
Inventor
Martin D Burke
Brice E Uno
Souvik Rakshit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana-Champaign
University of Illinois System
Original Assignee
University of Illinois at Urbana-Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana-Champaign, University of Illinois System filed Critical University of Illinois at Urbana-Champaign
Application granted granted Critical
Publication of ES3072651T3 publication Critical patent/ES3072651T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES15851160T 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin b Active ES3072651T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462065330P 2014-10-17 2014-10-17
PCT/US2015/055899 WO2016061437A1 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin b

Publications (1)

Publication Number Publication Date
ES3072651T3 true ES3072651T3 (en) 2026-07-03

Family

ID=55747385

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15851160T Active ES3072651T3 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin b

Country Status (7)

Country Link
US (2) US10087206B2 (enExample)
EP (1) EP3206695B1 (enExample)
JP (1) JP6755859B2 (enExample)
AU (2) AU2015331904B2 (enExample)
ES (1) ES3072651T3 (enExample)
PT (1) PT3206695T (enExample)
WO (1) WO2016061437A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6543272B2 (ja) * 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
ES3072651T3 (en) * 2014-10-17 2026-07-03 Univ Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b
PT3283171T (pt) 2015-04-15 2021-07-14 Sfunga Therapeutics Inc Derivados de anfotericina b
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1008720A (en) 1910-11-14 1911-11-14 John Knape Adjustable bracket.
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
CA2551859C (en) * 2003-12-30 2011-10-04 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2014059436A1 (en) * 2012-10-12 2014-04-17 The Board Of Trustees Of The University Of Illinois Electronic tuning of site selectivity
WO2014165676A1 (en) * 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
JP6543272B2 (ja) * 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
MX378786B (es) * 2014-06-12 2025-03-11 Shionogi & Co Derivado de macrólido de polieno.
ES3072651T3 (en) * 2014-10-17 2026-07-03 Univ Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b

Also Published As

Publication number Publication date
WO2016061437A1 (en) 2016-04-21
JP6755859B2 (ja) 2020-09-16
US10087206B2 (en) 2018-10-02
US10683318B2 (en) 2020-06-16
JP2017532329A (ja) 2017-11-02
AU2015331904A1 (en) 2017-05-25
AU2015331904B2 (en) 2021-02-11
EP3206695A4 (en) 2018-06-20
US20170233427A1 (en) 2017-08-17
US20190127412A1 (en) 2019-05-02
EP3206695A1 (en) 2017-08-23
AU2021202949B2 (en) 2023-07-13
EP3206695B1 (en) 2026-04-29
PT3206695T (pt) 2026-06-17
AU2021202949A1 (en) 2021-06-03