ES3055983T3 - Pegylation of fgf21 - Google Patents
Pegylation of fgf21Info
- Publication number
- ES3055983T3 ES3055983T3 ES20189107T ES20189107T ES3055983T3 ES 3055983 T3 ES3055983 T3 ES 3055983T3 ES 20189107 T ES20189107 T ES 20189107T ES 20189107 T ES20189107 T ES 20189107T ES 3055983 T3 ES3055983 T3 ES 3055983T3
- Authority
- ES
- Spain
- Prior art keywords
- peg
- reaction
- pegylation
- equiv
- additive system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258644P | 2015-11-23 | 2015-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES3055983T3 true ES3055983T3 (en) | 2026-02-17 |
Family
ID=57589163
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES20189107T Active ES3055983T3 (en) | 2015-11-23 | 2016-11-22 | Pegylation of fgf21 |
| ES16816042T Active ES2827776T3 (es) | 2015-11-23 | 2016-11-22 | Sistemas de aditivos para uso en la PEGilación de proteínas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16816042T Active ES2827776T3 (es) | 2015-11-23 | 2016-11-22 | Sistemas de aditivos para uso en la PEGilación de proteínas |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10617765B2 (https=) |
| EP (2) | EP3789395B1 (https=) |
| JP (2) | JP6921821B2 (https=) |
| KR (1) | KR102688003B1 (https=) |
| CN (2) | CN115819494A (https=) |
| CY (1) | CY1123699T1 (https=) |
| DK (1) | DK3380487T3 (https=) |
| ES (2) | ES3055983T3 (https=) |
| HR (1) | HRP20201832T1 (https=) |
| HU (1) | HUE052634T2 (https=) |
| LT (1) | LT3380487T (https=) |
| PL (1) | PL3380487T3 (https=) |
| PT (1) | PT3380487T (https=) |
| RS (1) | RS61072B1 (https=) |
| SI (1) | SI3380487T1 (https=) |
| SM (1) | SMT202000649T1 (https=) |
| WO (1) | WO2017091568A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3380487T (pt) * | 2015-11-23 | 2020-10-29 | Bristol Myers Squibb Co | Sistemas de aditivos para utilização na peguilação de proteínas |
| HRP20240016T1 (hr) * | 2018-09-11 | 2024-03-29 | Ambrx, Inc. | Konjugati polipeptida interleukina-2 i njihove uporabe |
| CN111484551B (zh) * | 2020-03-19 | 2022-02-11 | 北京翼方生物科技有限责任公司 | 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| EP0885613A1 (de) | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
| DE19734293A1 (de) | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
| US7329516B2 (en) * | 2004-03-17 | 2008-02-12 | Anticancer, Inc. | Methods for increasing protein polyethylene glycol (PEG) conjugation |
| US20060286657A1 (en) * | 2005-06-01 | 2006-12-21 | Samuel Zalipsky | Novel bioconjugation reactions for acylating polyethylene glycol reagents |
| CN104710503B (zh) * | 2005-11-08 | 2023-04-25 | Ambrx 公司 | 用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂 |
| CA2682147C (en) * | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| AU2014212308B2 (en) | 2013-01-30 | 2018-08-09 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
| WO2014176284A1 (en) | 2013-04-22 | 2014-10-30 | Avelas Biosciences, Inc. | Selective drug delivery compositions and methods of use |
| SMT202100388T1 (it) | 2014-10-24 | 2021-09-14 | Bristol Myers Squibb Co | Polipeptidi fgf-21 modificati e loro usi |
| PT3380487T (pt) * | 2015-11-23 | 2020-10-29 | Bristol Myers Squibb Co | Sistemas de aditivos para utilização na peguilação de proteínas |
-
2016
- 2016-11-22 PT PT168160422T patent/PT3380487T/pt unknown
- 2016-11-22 SM SM20200649T patent/SMT202000649T1/it unknown
- 2016-11-22 DK DK16816042.2T patent/DK3380487T3/da active
- 2016-11-22 HU HUE16816042A patent/HUE052634T2/hu unknown
- 2016-11-22 ES ES20189107T patent/ES3055983T3/es active Active
- 2016-11-22 KR KR1020187017508A patent/KR102688003B1/ko active Active
- 2016-11-22 RS RS20201382A patent/RS61072B1/sr unknown
- 2016-11-22 CN CN202211743414.4A patent/CN115819494A/zh active Pending
- 2016-11-22 LT LTEP16816042.2T patent/LT3380487T/lt unknown
- 2016-11-22 SI SI201630957T patent/SI3380487T1/sl unknown
- 2016-11-22 EP EP20189107.4A patent/EP3789395B1/en active Active
- 2016-11-22 WO PCT/US2016/063313 patent/WO2017091568A1/en not_active Ceased
- 2016-11-22 JP JP2018526713A patent/JP6921821B2/ja active Active
- 2016-11-22 PL PL16816042T patent/PL3380487T3/pl unknown
- 2016-11-22 CN CN201680067897.7A patent/CN108350025B/zh active Active
- 2016-11-22 US US15/776,923 patent/US10617765B2/en active Active
- 2016-11-22 ES ES16816042T patent/ES2827776T3/es active Active
- 2016-11-22 EP EP16816042.2A patent/EP3380487B1/en active Active
- 2016-11-22 HR HRP20201832TT patent/HRP20201832T1/hr unknown
-
2020
- 2020-02-21 US US16/797,361 patent/US11213589B2/en active Active
- 2020-11-20 CY CY20201101102T patent/CY1123699T1/el unknown
-
2021
- 2021-07-28 JP JP2021123154A patent/JP7257457B2/ja active Active
- 2021-12-03 US US17/541,636 patent/US20220160883A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2827776T3 (es) | 2021-05-24 |
| EP3789395A1 (en) | 2021-03-10 |
| JP7257457B2 (ja) | 2023-04-13 |
| RS61072B1 (sr) | 2020-12-31 |
| PT3380487T (pt) | 2020-10-29 |
| US11213589B2 (en) | 2022-01-04 |
| SI3380487T1 (sl) | 2020-11-30 |
| HRP20201832T1 (hr) | 2021-01-08 |
| LT3380487T (lt) | 2020-12-28 |
| WO2017091568A1 (en) | 2017-06-01 |
| US20190351065A1 (en) | 2019-11-21 |
| CN108350025B (zh) | 2023-02-21 |
| US20220160883A1 (en) | 2022-05-26 |
| WO2017091568A8 (en) | 2018-01-04 |
| EP3380487A1 (en) | 2018-10-03 |
| JP2019503994A (ja) | 2019-02-14 |
| PL3380487T3 (pl) | 2020-12-28 |
| HUE052634T2 (hu) | 2021-05-28 |
| EP3380487B1 (en) | 2020-09-02 |
| US20200276319A1 (en) | 2020-09-03 |
| CY1123699T1 (el) | 2022-03-24 |
| JP6921821B2 (ja) | 2021-08-18 |
| CN115819494A (zh) | 2023-03-21 |
| EP3789395B1 (en) | 2025-08-27 |
| US10617765B2 (en) | 2020-04-14 |
| JP2021176890A (ja) | 2021-11-11 |
| KR20180081610A (ko) | 2018-07-16 |
| SMT202000649T1 (it) | 2021-01-05 |
| CN108350025A (zh) | 2018-07-31 |
| KR102688003B1 (ko) | 2024-07-23 |
| DK3380487T3 (da) | 2020-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES3055983T3 (en) | Pegylation of fgf21 | |
| US20230295221A1 (en) | Efficient peptide condensation method for difficult sequences | |
| CA2918064A1 (en) | Amino acid derivatives | |
| CA3095071A1 (en) | Non-natural amatoxin-type antibody conjugate | |
| Guthrie et al. | Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides | |
| Dahiya et al. | Toward the synthesis and pharmacological screening of a natural cycloheptapeptide of plant origin | |
| Arndt et al. | Solution phase synthesis and purification of the minigramicidin ion channels and a succinyl-linked gramicidin | |
| TW202330571A (zh) | 具有光裂解部位的化合物、連結物及使用此的篩選方法 | |
| US9850469B2 (en) | Methods of stapling and unstapling peptides and proteins | |
| Yang et al. | Carbon dioxide enhances sulphur-selective conjugate addition reactions | |
| Hughes | Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis | |
| US11053279B2 (en) | Methods for the site-selective coupling of a first agent to a second agent | |
| KR101692992B1 (ko) | 고리형 펩타이드의 사전 활성화 합성방법 및 이에 따라 합성된 고리형 펩타이드 | |
| Islam | Cyclization-Based Site-Selective N-Terminal Cysteine Conjugation, Peptide Stapling and Histone Deacetylase (HDAC) Probing | |
| HK40104266A (zh) | 具有光开裂性部位的化合物、连结体和应用其的筛选方法 | |
| Kang | Native chemical thioesterification: synthesis of peptide and protein thioesters through an N→ S acyl shift | |
| ES2367843T3 (es) | Tecnología de lantionina ortogonal protegida de forma diferencial. | |
| Misicka | 12 General Strategies of Peptide Synthesis | |
| Postma | Novel Disulfide Formation Strategies in Peptide Synthesis | |
| Méret | Development of an efficient and flexible method for the solid-phase synthesis of N-hydroxypolyamine derivatives | |
| EA023323B1 (ru) | Разветвленный ацилазидный пегилирующий агент, способ его получения и способ получения пегилированного интерферона |