ES3054697T3 - Chlorotoxin conjugates and methods of use thereof - Google Patents

Chlorotoxin conjugates and methods of use thereof

Info

Publication number
ES3054697T3
ES3054697T3 ES14846407T ES14846407T ES3054697T3 ES 3054697 T3 ES3054697 T3 ES 3054697T3 ES 14846407 T ES14846407 T ES 14846407T ES 14846407 T ES14846407 T ES 14846407T ES 3054697 T3 ES3054697 T3 ES 3054697T3
Authority
ES
Spain
Prior art keywords
methods
chlorotoxin conjugates
chlorotoxin
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14846407T
Other languages
English (en)
Inventor
Claudia Jochheim
Dennis Miller
Natalie Nairn
Mark Stroud
Kelly Byrnes-Blake
Stacey Hansen
Julia Novak
Valorie Wiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blaze Bioscience Inc
Original Assignee
Blaze Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blaze Bioscience Inc filed Critical Blaze Bioscience Inc
Application granted granted Critical
Publication of ES3054697T3 publication Critical patent/ES3054697T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • G01N33/5751—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
ES14846407T 2013-09-17 2014-09-17 Chlorotoxin conjugates and methods of use thereof Active ES3054697T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361879108P 2013-09-17 2013-09-17
US201361879096P 2013-09-17 2013-09-17
US201461990101P 2014-05-07 2014-05-07
PCT/US2014/056177 WO2015042202A1 (en) 2013-09-17 2014-09-17 Chlorotoxin conjugates and methods of use thereof

Publications (1)

Publication Number Publication Date
ES3054697T3 true ES3054697T3 (en) 2026-02-05

Family

ID=52689364

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14846407T Active ES3054697T3 (en) 2013-09-17 2014-09-17 Chlorotoxin conjugates and methods of use thereof

Country Status (10)

Country Link
US (3) US20160096869A1 (es)
EP (1) EP3046572B1 (es)
JP (2) JP6652923B2 (es)
CN (1) CN105813648A (es)
AU (5) AU2014323563B9 (es)
BR (1) BR112016005802A2 (es)
CA (1) CA2924521A1 (es)
ES (1) ES3054697T3 (es)
IL (1) IL244665B (es)
WO (1) WO2015042202A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010101628A2 (en) 2009-03-02 2010-09-10 Massachusetts Institute Of Technology Methods and products for in vivo enzyme profiling
EP3950704A1 (en) 2011-03-15 2022-02-09 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
EP3004374B1 (en) 2013-06-07 2020-08-12 Massachusetts Institute of Technology Affinity-based detection of ligand-encoded synthetic biomarkers
ES3054697T3 (en) * 2013-09-17 2026-02-05 Blaze Bioscience Inc Chlorotoxin conjugates and methods of use thereof
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US20180371033A1 (en) * 2015-06-26 2018-12-27 Fred Hutchinson Cancer Research Center Therapeutic peptides and methods of use thereof
EP3313427A4 (en) * 2015-06-26 2018-12-26 Fred Hutchinson Cancer Research Center Therapeutic peptides and methods of use thereof
US11448643B2 (en) 2016-04-08 2022-09-20 Massachusetts Institute Of Technology Methods to specifically profile protease activity at lymph nodes
US20190161523A1 (en) 2016-04-12 2019-05-30 Blaze Bioscience, Inc. Methods of treatment using chlorotoxin conjugates
EP3442555A4 (en) * 2016-04-15 2020-04-01 Blaze Bioscience, Inc. METHOD FOR TREATING BREAST CANCER
WO2017181149A1 (en) 2016-04-15 2017-10-19 Blaze Bioscience, Inc. Methods of treating breast cancer
US11428689B2 (en) 2016-05-05 2022-08-30 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
RU2638805C1 (ru) * 2016-11-23 2017-12-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" министерства здравоохранения Российской Федерации Способ дифференциальной диагностики аденомы с дисплазией iii степени и ранней аденокарциномы толстой кишки
WO2018119001A1 (en) * 2016-12-19 2018-06-28 Fred Hutchinson Cancer Research Center Peptide-antibody compositions and methods of use thereof
US12043619B2 (en) 2017-04-03 2024-07-23 Massachusetts Institute Of Technology Near and shortwave infrared polymethine dyes
EP3607085A1 (en) 2017-04-07 2020-02-12 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
US11292778B2 (en) 2017-06-05 2022-04-05 The Regents Of The University Of California Heterocyclyl polymethine IR chromophores
CA3086040A1 (en) * 2017-12-19 2019-06-27 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
AU2019217628B2 (en) * 2018-02-06 2024-09-05 Gen-Probe Incorporated Far-red dye probe formulations
US12173349B2 (en) 2018-09-25 2024-12-24 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
CN109342414B (zh) * 2018-11-22 2021-06-01 江苏师范大学 一种可视化传感阵列芯片及其制备方法
DE102018220631A1 (de) * 2018-11-29 2020-06-04 B. Braun Melsungen Ag Wässrige Zusammensetzung, insbesondere zur Behandlung von Schleimhaut und/oder Wunden
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
AU2020357862A1 (en) * 2019-10-02 2022-03-17 Blaze Bioscience, Inc. Systems and methods for vascular and structural imaging
US20230117827A1 (en) * 2020-01-17 2023-04-20 Fluoguide A/S Composition comprising a fluorophore labelled upar-targeting peptide conjugate
US11851421B2 (en) * 2020-06-23 2023-12-26 Bracco Imaging S.P.A. Near-infrared cyanine dyes and conjugates thereof
US20240115717A1 (en) 2020-12-30 2024-04-11 Vrg Therapeutics Kft. Chlorotoxin derivatives and use thereof
CN113447583A (zh) * 2021-06-25 2021-09-28 河北冀安检测服务有限公司 一种盐酸氨溴索氯化钠注射液与包材相容性的检测方法
CN113861717A (zh) * 2021-11-09 2021-12-31 西安康福诺生物科技有限公司 一种用于荧光标记的水溶性吲哚菁绿染料及其合成方法
CN119768391A (zh) * 2022-10-12 2025-04-04 江苏亚虹医药科技股份有限公司 吲哚酞菁类化合物、其制备方法及在肿瘤诊断成像中的应用
WO2024143263A1 (ja) 2022-12-26 2024-07-04 富士フイルム株式会社 蛍光強度増強剤、蛍光標識された標的生体物質の蛍光強度増強方法、及び、蛍光検出用キット
WO2024156920A1 (en) * 2023-01-29 2024-08-02 Universität Zürich Fluorogenic polymethine dyes
CN118767155A (zh) * 2023-04-10 2024-10-15 湖南中晟全肽生物科技股份有限公司 一种氯毒素的多肽偶联物及其用途
CN118084769B (zh) * 2024-02-28 2026-01-20 中国科学院基础医学与肿瘤研究所(筹) 基于花菁染料的靶向型近红外荧光探针的制备和应用
CN118304441B (zh) * 2024-04-03 2025-03-18 江苏省人民医院（南京医科大学第一附属医院） 一种肿瘤靶向的荧光探针及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3669752B2 (ja) * 1995-01-30 2005-07-13 第一化学薬品株式会社 診断用マーカー
KR100397020B1 (ko) * 1995-01-30 2004-04-29 다이이치 가가쿠 야쿠힝 가부시키가이샤 진단용마커
US8053415B2 (en) 2005-01-21 2011-11-08 Washington University In St. Louis Compounds having RD targeting motifs
ATE502048T1 (de) 2005-04-22 2011-04-15 Univ Washington Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs
CA2788824C (en) 2010-02-04 2019-03-12 Morphotek, Inc. Chlorotoxin polypeptides and conjugates and uses thereof
CN103097403B (zh) * 2010-05-11 2017-04-19 弗雷德哈钦森癌症研究中心 氯毒素变体、缀合物及其使用方法
WO2012039741A1 (en) * 2010-09-22 2012-03-29 The Board Of Regents Of The University Of Texas System Novel block copolymer and micelle compositions and methods of use thereof
ES3054697T3 (en) * 2013-09-17 2026-02-05 Blaze Bioscience Inc Chlorotoxin conjugates and methods of use thereof

Also Published As

Publication number Publication date
IL244665A0 (en) 2016-04-21
EP3046572A1 (en) 2016-07-27
EP3046572B1 (en) 2025-07-30
WO2015042202A1 (en) 2015-03-26
AU2020200116A1 (en) 2020-01-30
AU2014323563A1 (en) 2016-04-14
US20250115648A1 (en) 2025-04-10
CA2924521A1 (en) 2015-03-26
AU2021202814A1 (en) 2021-05-27
AU2014323563B9 (en) 2019-10-24
AU2021202814B2 (en) 2023-02-02
EP3046572A4 (en) 2017-06-28
JP2016534147A (ja) 2016-11-04
BR112016005802A2 (pt) 2017-09-12
AU2023202389A1 (en) 2023-07-06
US20200188536A1 (en) 2020-06-18
JP6994011B2 (ja) 2022-02-03
AU2014323563B2 (en) 2019-10-10
JP2020019779A (ja) 2020-02-06
AU2020200116B2 (en) 2021-02-25
US20160096869A1 (en) 2016-04-07
AU2024264675A1 (en) 2024-12-19
CN105813648A (zh) 2016-07-27
AU2023202389B2 (en) 2024-08-15
JP6652923B2 (ja) 2020-02-26
IL244665B (en) 2019-03-31

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