ES3018234T3 - Fluralaner for use in the treatment of demodicosis - Google Patents

Fluralaner for use in the treatment of demodicosis Download PDF

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Publication number
ES3018234T3
ES3018234T3 ES15817303T ES15817303T ES3018234T3 ES 3018234 T3 ES3018234 T3 ES 3018234T3 ES 15817303 T ES15817303 T ES 15817303T ES 15817303 T ES15817303 T ES 15817303T ES 3018234 T3 ES3018234 T3 ES 3018234T3
Authority
ES
Spain
Prior art keywords
treatment
demodicosis
dogs
dog
isoxazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15817303T
Other languages
English (en)
Spanish (es)
Inventor
Heike Williams
Anja Heckeroth
Janina Tänzler
Régis Frenais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intervet International BV
Original Assignee
Intervet International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet International BV filed Critical Intervet International BV
Application granted granted Critical
Publication of ES3018234T3 publication Critical patent/ES3018234T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ES15817303T 2014-12-22 2015-12-21 Fluralaner for use in the treatment of demodicosis Active ES3018234T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14199562 2014-12-22
PCT/EP2015/080744 WO2016102437A1 (en) 2014-12-22 2015-12-21 Use of isoxazoline compounds for treating demodicosis

Publications (1)

Publication Number Publication Date
ES3018234T3 true ES3018234T3 (en) 2025-05-14

Family

ID=52146273

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15817303T Active ES3018234T3 (en) 2014-12-22 2015-12-21 Fluralaner for use in the treatment of demodicosis
ES21213190T Active ES3037078T3 (en) 2014-12-22 2015-12-21 Isoxazoline compounds for use in treating demodicosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES21213190T Active ES3037078T3 (en) 2014-12-22 2015-12-21 Isoxazoline compounds for use in treating demodicosis

Country Status (14)

Country Link
US (3) US20170348286A1 (OSRAM)
EP (3) EP3236960B1 (OSRAM)
JP (1) JP6706262B2 (OSRAM)
CN (2) CN114681453A (OSRAM)
AU (3) AU2015371175B2 (OSRAM)
BR (1) BR112017013286A2 (OSRAM)
CA (1) CA2971296A1 (OSRAM)
DK (2) DK4008329T3 (OSRAM)
ES (2) ES3018234T3 (OSRAM)
FI (2) FI3236960T3 (OSRAM)
PL (2) PL3236960T3 (OSRAM)
PT (2) PT3236960T (OSRAM)
RU (1) RU2709198C2 (OSRAM)
WO (1) WO2016102437A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
RU2709198C2 (ru) 2014-12-22 2019-12-17 Интервет Интернэшнл Б.В. Применение изоксазолиновых соединений для лечения демодекоза
WO2018039508A1 (en) * 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
CN107501199A (zh) * 2017-08-16 2017-12-22 南京农业大学 氟雷拉纳单体化合物的提取和纯化方法
KR20200111177A (ko) * 2017-12-15 2020-09-28 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
US11880349B2 (en) 2019-04-30 2024-01-23 Salesforce, Inc. System or method to query or search a metadata driven distributed ledger or blockchain
MX2022007455A (es) 2019-12-18 2022-08-15 Elanco Tiergesundheit Ag Derivados de isoxazolina como plaguicidas.
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
CN115785017B (zh) * 2022-12-06 2023-12-08 海利尔药业集团股份有限公司 一种取代的苯酰胺异噁唑啉衍生物或其作为农药可接受的盐、组合物及其用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2067863C1 (ru) * 1994-05-25 1996-10-20 Казанский государственный технологический университет Акарицидный состав для лечения чесотки домашних животных
JP4883296B2 (ja) 2004-03-05 2012-02-22 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
DE102004053964A1 (de) * 2004-11-09 2006-05-11 Bayer Healthcare Ag Mittel gegen Demodikose
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX2009013748A (es) 2007-06-27 2010-01-26 Du Pont Metodo de control de plagas en animales.
TWI556741B (zh) * 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI411395B (zh) 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
ES2442342T3 (es) 2008-12-18 2014-02-11 Novartis Ag Derivados de las isoxazolinas y su uso como pesticida
BRPI0923009B1 (pt) 2008-12-19 2018-07-17 Elanco Tiergesundheit Ag compostos de isoxazolina, composição para o controle de parasitas e uso de compostos de isoxazolina para o preparo de composição para o controle de parasitas
ES2908094T5 (en) 2010-12-27 2025-08-12 Intervet Int Bv Topical localized isoxazoline formulation
PL2658541T3 (pl) 2010-12-27 2022-04-04 Intervet International B.V. Preparat izoksazoliny do stosowania miejscowego zawierający glikofurol
AU2012226475C1 (en) * 2011-03-10 2015-08-06 Zoetis Services Llc Spirocyclic isoxazoline derivatives as antiparasitic agents
IN2014CN02128A (OSRAM) 2011-09-12 2015-05-29 Merial Ltd
PT3216448T (pt) * 2012-02-06 2019-07-08 Boehringer Ingelheim Animal Health Usa Inc Composições veterinárias orais parasiticidas que compreendem agentes, métodos e métodos ativos que agem sistemicamente
WO2013150052A1 (en) 2012-04-04 2013-10-10 Intervet International B.V. Soft chewable pharmaceutical products
WO2014090918A1 (en) * 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
PL3082867T3 (pl) 2013-12-20 2024-05-13 Intervet International B.V. Kompozycje izoksazoliny i ich zastosowanie w zapobieganiu lub leczeniu inwazji pasożytów u zwierząt
RU2709198C2 (ru) 2014-12-22 2019-12-17 Интервет Интернэшнл Б.В. Применение изоксазолиновых соединений для лечения демодекоза

Also Published As

Publication number Publication date
DK4008329T3 (da) 2025-08-18
JP6706262B2 (ja) 2020-06-03
CA2971296A1 (en) 2016-06-30
US20180318265A1 (en) 2018-11-08
RU2017126029A (ru) 2019-01-24
AU2015371175B2 (en) 2021-03-04
US20200405692A1 (en) 2020-12-31
AU2023219972A1 (en) 2023-09-14
EP3236960A1 (en) 2017-11-01
CN106999475A (zh) 2017-08-01
US10799483B2 (en) 2020-10-13
EP4008329B1 (en) 2025-06-11
AU2015371175A1 (en) 2017-06-15
CN114681453A (zh) 2022-07-01
CN106999475B (zh) 2022-10-25
FI4008329T3 (fi) 2025-08-22
WO2016102437A1 (en) 2016-06-30
RU2709198C2 (ru) 2019-12-17
PT4008329T (pt) 2025-07-30
EP4008329A1 (en) 2022-06-08
US20170348286A1 (en) 2017-12-07
PL3236960T3 (pl) 2025-07-07
AU2021203686A1 (en) 2021-07-01
PT3236960T (pt) 2025-04-08
EP4599830A2 (en) 2025-08-13
FI3236960T3 (fi) 2025-04-05
BR112017013286A2 (pt) 2018-03-06
EP3236960B1 (en) 2025-01-29
RU2017126029A3 (OSRAM) 2019-06-20
JP2017538767A (ja) 2017-12-28
DK3236960T3 (da) 2025-03-31
AU2023219972B2 (en) 2025-05-29
PL4008329T3 (pl) 2025-11-17
ES3037078T3 (en) 2025-09-26
EP4599830A3 (en) 2025-11-19

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