ES2992081T3 - Derivados de tiazolopiridina como antagonistas del receptor de adenosina - Google Patents

Derivados de tiazolopiridina como antagonistas del receptor de adenosina Download PDF

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Publication number
ES2992081T3
ES2992081T3 ES20700918T ES20700918T ES2992081T3 ES 2992081 T3 ES2992081 T3 ES 2992081T3 ES 20700918 T ES20700918 T ES 20700918T ES 20700918 T ES20700918 T ES 20700918T ES 2992081 T3 ES2992081 T3 ES 2992081T3
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Prior art keywords
cancer
group
compound
compounds
spp
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ES20700918T
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English (en)
Spanish (es)
Inventor
Krauel Eva-Maria Tanzer
Kai Schiemann
Alejandro Crespo
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Merck Patent GmbH
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Merck Patent GmbH
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES20700918T 2019-01-22 2020-01-21 Derivados de tiazolopiridina como antagonistas del receptor de adenosina Active ES2992081T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19152961 2019-01-22
PCT/EP2020/051347 WO2020152132A1 (en) 2019-01-22 2020-01-21 Thiazolopyridine derivatives as adenosine receptor antagonists

Publications (1)

Publication Number Publication Date
ES2992081T3 true ES2992081T3 (es) 2024-12-09

Family

ID=65199346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20700918T Active ES2992081T3 (es) 2019-01-22 2020-01-21 Derivados de tiazolopiridina como antagonistas del receptor de adenosina

Country Status (23)

Country Link
US (1) US12344623B2 (enExample)
EP (1) EP3914600B1 (enExample)
JP (1) JP7600119B2 (enExample)
KR (1) KR102891741B1 (enExample)
CN (1) CN113939520B (enExample)
AR (1) AR117844A1 (enExample)
AU (1) AU2020211697B2 (enExample)
BR (1) BR112021014406A2 (enExample)
CA (1) CA3127284A1 (enExample)
DK (1) DK3914600T3 (enExample)
ES (1) ES2992081T3 (enExample)
FI (1) FI3914600T3 (enExample)
HR (1) HRP20241385T1 (enExample)
HU (1) HUE068968T2 (enExample)
IL (1) IL285024A (enExample)
LT (1) LT3914600T (enExample)
MX (1) MX2021008510A (enExample)
PL (1) PL3914600T3 (enExample)
PT (1) PT3914600T (enExample)
RS (1) RS66038B1 (enExample)
SG (1) SG11202107858WA (enExample)
SI (1) SI3914600T1 (enExample)
WO (1) WO2020152132A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4351640A1 (en) 2021-06-07 2024-04-17 Ares Trading S.A. Combination treatment of cancer
JP2025512384A (ja) 2022-04-13 2025-04-17 ギリアード サイエンシーズ, インコーポレイテッド Trop-2発現がんを治療するための併用療法
CN119654328A (zh) 2022-08-02 2025-03-18 默克专利股份公司 (S)-7-氧杂-2-氮杂-螺[4.5]癸烷-2-甲酸[7-(3,6-二氢-2H-吡喃-4-基)-4-甲氧基-噻唑并[4,5-c]吡啶-2-基]-酰胺的新型结晶形式及其共晶形式
CN118206542B (zh) * 2023-03-22 2025-06-27 沈阳药科大学 一种化合物及其制备方法和在制备sEH抑制剂与PPARs激动剂中的应用
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors

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US4207554A (en) 1972-08-04 1980-06-10 Med-El Inc. Method and apparatus for automated classification and analysis of cells
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69720965T2 (de) 1996-02-13 2004-02-05 Astrazeneca Ab Chinazolinderivate und deren verwendung als vegf hemmer
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
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AU1688599A (en) 1998-01-05 1999-07-26 Eisai Co. Ltd. Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
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US6841549B1 (en) 1999-07-02 2005-01-11 Eisai Co., Ltd. Condensed imidazole compounds and a therapeutic agent for diabetes mellitus
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
AU2001281817B2 (en) * 2000-06-21 2005-11-24 F. Hoffmann-La Roche Ag Benzothiazole derivatives
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EP1465634B1 (en) 2001-12-12 2014-10-22 The Government of the United States of America, as represented by the Secretary Department of Health and Human Services Methods for using adenosine receptor inhibitors to enhance immune response and inflammation
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US20080070932A1 (en) 2003-04-09 2008-03-20 Chi Vu Triazolo[ 1,5-A] Pyrimidines And Pyrazolo[ 1,5-A] Pyrimidines And Methods Of Making And Using The Same
PT1636223E (pt) 2003-05-19 2008-05-06 F Hoffmann-La Roche Ag Derivados de benzotiazole como ligandos de receptores da adenosina
RU2006112847A (ru) * 2003-09-19 2007-11-10 Ф. Хоффманн-Ля Рош Аг (Ch) Производные тиазолопиридина в качестве лигандов аденозинового рецептора
US7054288B2 (en) * 2004-02-13 2006-05-30 Interdigital Technology Corporation Method and apparatus for providing fast detection of a high speed shared control channel
DE102004008908A1 (de) * 2004-02-24 2005-09-08 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Ansteuerschaltung für Wandler
FR2867354A1 (fr) * 2004-03-09 2005-09-16 Joseph Vaillant Ferrure mecanique pour sabot, notamment pour cheval de sport
JP5202946B2 (ja) 2004-07-22 2013-06-05 エフ.ホフマン−ラ ロシュ アーゲー ベンゾチアゾール誘導体
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
PL3634417T3 (pl) * 2017-05-17 2023-09-25 Arcus Biosciences, Inc. Pochodne chinazolino-pirazolowe do leczenia chorób związanych z nowotworem
PT3661941T (pt) * 2017-08-01 2023-03-16 Merck Patent Gmbh Derivados tiazolopiridina como antagonistas do recetor de adenosina

Also Published As

Publication number Publication date
AU2020211697B2 (en) 2025-08-14
US20220119412A1 (en) 2022-04-21
HRP20241385T1 (hr) 2024-12-20
BR112021014406A2 (pt) 2021-12-07
PT3914600T (pt) 2024-10-04
CN113939520B (zh) 2024-11-22
HUE068968T2 (hu) 2025-02-28
FI3914600T3 (fi) 2024-10-31
EP3914600B1 (en) 2024-08-07
CA3127284A1 (en) 2020-07-30
AR117844A1 (es) 2021-09-01
US12344623B2 (en) 2025-07-01
WO2020152132A1 (en) 2020-07-30
EP3914600A1 (en) 2021-12-01
AU2020211697A1 (en) 2021-09-09
SI3914600T1 (sl) 2025-03-31
KR20210116572A (ko) 2021-09-27
SG11202107858WA (en) 2021-08-30
CN113939520A (zh) 2022-01-14
IL285024A (en) 2021-09-30
JP7600119B2 (ja) 2024-12-16
PL3914600T3 (pl) 2024-12-23
LT3914600T (lt) 2024-12-27
RS66038B1 (sr) 2024-11-29
DK3914600T3 (da) 2024-10-07
MX2021008510A (es) 2021-09-21
KR102891741B1 (ko) 2025-11-26
JP2022524914A (ja) 2022-05-11

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