ES2987433T3 - Alineación cinemática y prótesis femoral y tibial novedosa - Google Patents
Alineación cinemática y prótesis femoral y tibial novedosa Download PDFInfo
- Publication number
- ES2987433T3 ES2987433T3 ES15779900T ES15779900T ES2987433T3 ES 2987433 T3 ES2987433 T3 ES 2987433T3 ES 15779900 T ES15779900 T ES 15779900T ES 15779900 T ES15779900 T ES 15779900T ES 2987433 T3 ES2987433 T3 ES 2987433T3
- Authority
- ES
- Spain
- Prior art keywords
- axis
- femur
- tibia
- guide
- tibial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000002303 tibia Anatomy 0.000 claims abstract description 299
- 210000000689 upper leg Anatomy 0.000 claims abstract description 239
- 238000000034 method Methods 0.000 claims abstract description 106
- 210000003127 knee Anatomy 0.000 claims abstract description 84
- 210000004417 patella Anatomy 0.000 claims abstract description 56
- 210000000629 knee joint Anatomy 0.000 claims abstract description 46
- 238000011882 arthroplasty Methods 0.000 claims abstract description 14
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 229910001256 stainless steel alloy Inorganic materials 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 238000013519 translation Methods 0.000 abstract description 18
- 239000007943 implant Substances 0.000 description 69
- 210000002967 posterior cruciate ligament Anatomy 0.000 description 43
- 210000000988 bone and bone Anatomy 0.000 description 42
- 230000000399 orthopedic effect Effects 0.000 description 32
- 238000011883 total knee arthroplasty Methods 0.000 description 31
- 238000002271 resection Methods 0.000 description 30
- 238000002594 fluoroscopy Methods 0.000 description 23
- 210000003041 ligament Anatomy 0.000 description 23
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- 241001227561 Valgus Species 0.000 description 6
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- 210000002082 fibula Anatomy 0.000 description 5
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- 230000000803 paradoxical effect Effects 0.000 description 2
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- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010064516 Femoral anteversion Diseases 0.000 description 1
- 206010023204 Joint dislocation Diseases 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000013150 knee replacement Methods 0.000 description 1
- 210000000528 lesser trochanter Anatomy 0.000 description 1
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- 210000004285 patellofemoral joint Anatomy 0.000 description 1
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- 210000004353 tibial menisci Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4603—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/461—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof of knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/14—Surgical saws
- A61B17/15—Guides therefor
- A61B17/154—Guides therefor for preparing bone for knee prosthesis
- A61B17/157—Cutting tibia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/16—Instruments for performing osteoclasis; Drills or chisels for bones; Trepans
- A61B17/17—Guides or aligning means for drills, mills, pins or wires
- A61B17/1739—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body
- A61B17/1764—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body for the knee
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3859—Femoral components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4684—Trial or dummy prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/90—Guides therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B2017/568—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor produced with shape and dimensions specific for an individual patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/389—Tibial components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2002/4632—Special tools for implanting artificial joints using computer-controlled surgery, e.g. robotic surgery
- A61F2002/4633—Special tools for implanting artificial joints using computer-controlled surgery, e.g. robotic surgery for selection of endoprosthetic joints or for pre-operative planning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2002/4687—Mechanical guides for implantation instruments
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Dentistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461979034P | 2014-04-14 | 2014-04-14 | |
| US201462013198P | 2014-06-17 | 2014-06-17 | |
| US201462022894P | 2014-07-10 | 2014-07-10 | |
| PCT/US2015/025822 WO2015160852A1 (en) | 2014-04-14 | 2015-04-14 | Kinematic alignment and novel femoral and tibial prosthetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2987433T3 true ES2987433T3 (es) | 2024-11-14 |
Family
ID=54324513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15779900T Active ES2987433T3 (es) | 2014-04-14 | 2015-04-14 | Alineación cinemática y prótesis femoral y tibial novedosa |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9901463B2 (enExample) |
| EP (1) | EP3131483B1 (enExample) |
| JP (2) | JP6563418B2 (enExample) |
| CA (2) | CA2945799C (enExample) |
| ES (1) | ES2987433T3 (enExample) |
| WO (1) | WO2015160852A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6563418B2 (ja) | 2014-04-14 | 2019-08-21 | ラシュワン マフホウズ，モハメド | 動態位置合わせ並びに新規な大腿骨人工装具及び脛骨人口装具 |
| US10154239B2 (en) | 2014-12-30 | 2018-12-11 | Onpoint Medical, Inc. | Image-guided surgery with surface reconstruction and augmented reality visualization |
| CA2971005C (en) * | 2015-01-12 | 2022-08-16 | Ao Technology Ag | Method for manufacturing an auxiliary device suitable for the manufacture of a patient customized implant |
| EP3302320B1 (en) | 2015-05-26 | 2022-11-16 | McAuliffe, Michael | Method of designing a surgical device |
| WO2017011576A2 (en) * | 2015-07-13 | 2017-01-19 | Mako Surgical Corp. | Lower extremities leg length calculation method |
| US10121066B1 (en) | 2017-11-16 | 2018-11-06 | Blast Motion Inc. | Method of determining joint stress from sensor data |
| US9532845B1 (en) | 2015-08-11 | 2017-01-03 | ITKR Software LLC | Methods for facilitating individualized kinematically aligned total knee replacements and devices thereof |
| US10555774B1 (en) | 2016-07-05 | 2020-02-11 | Smith & Nephew, Inc. | Interactive anterior-posterior axis determination |
| US10588696B2 (en) * | 2016-08-03 | 2020-03-17 | Mako Surgical Corp. | Patella implant planning |
| WO2019077388A1 (en) * | 2017-10-16 | 2019-04-25 | Stryker European Holdings I, Llc | DEVICE FOR DETERMINING THE ANGLE OF ANTVERSION |
| BR112020021556A2 (pt) * | 2018-06-20 | 2021-03-02 | Techmah Medical Llc | métodos e dispositivos para cirurgia do joelho com sensores inerciais |
| US11766300B2 (en) | 2018-09-14 | 2023-09-26 | Zimmer, Inc. | Kinematically aligned robotic total knee arthroplasty |
| AU2018441886B2 (en) | 2018-09-19 | 2025-07-17 | Mako Surgical Corp. | Method of surgery |
| US11553969B1 (en) | 2019-02-14 | 2023-01-17 | Onpoint Medical, Inc. | System for computation of object coordinates accounting for movement of a surgical site for spinal and other procedures |
| US11129720B2 (en) * | 2019-03-05 | 2021-09-28 | Jonathan P. GARINO | Cruciate replacing artificial knee |
| US11278416B2 (en) | 2019-11-14 | 2022-03-22 | Howmedica Osteonics Corp. | Concentric keel TKA |
| CN111583240B (zh) * | 2020-05-09 | 2023-05-26 | 北京天智航医疗科技股份有限公司 | 一种股骨端前后轴线的确定方法、装置和计算机设备 |
| WO2022040952A1 (zh) * | 2020-08-26 | 2022-03-03 | 王志坚 | 人工膝关节置换术的运动轴定位器 |
| IT202000022741A1 (it) * | 2020-09-25 | 2022-03-25 | Medacta Int Sa | Impianto di prova tibio-femorale |
| AU2021369677B2 (en) | 2020-10-30 | 2025-10-02 | Mako Surgical Corp. | Robotic surgical system with recovery alignment |
| US12182956B2 (en) | 2021-07-01 | 2024-12-31 | Microport Orthopedics Holdings Inc. | Systems and methods of using three-dimensional image reconstruction to aid in assessing bone or soft tissue aberrations for orthopedic surgery |
| JP2024526601A (ja) | 2021-07-20 | 2024-07-19 | マイクロポート オーソペディックス ホールディングス インク | 写真測量を使用して整形外科手術のための患者固有のガイドを作製するためのシステム及び方法 |
| USD1044829S1 (en) | 2021-07-29 | 2024-10-01 | Mako Surgical Corp. | Display screen or portion thereof with graphical user interface |
| WO2023056261A1 (en) | 2021-09-30 | 2023-04-06 | Microport Orthopedics Holdings Inc. | Systems and methods of using photogrammetry for intraoperatively aligning surgical elements |
| US12433761B1 (en) | 2022-01-20 | 2025-10-07 | Onpoint Medical, Inc. | Systems and methods for determining the shape of spinal rods and spinal interbody devices for use with augmented reality displays, navigation systems and robots in minimally invasive spine procedures |
| CN114711760B (zh) * | 2022-04-06 | 2023-01-24 | 哈尔滨工业大学 | 一种关节轴线计算方法 |
| EP4543352A1 (en) * | 2022-07-27 | 2025-04-30 | The Cleveland Clinic Foundation | System and method for extraction of joint-specific movement capacity and motion signature from imaging |
| WO2024238453A1 (en) * | 2023-05-12 | 2024-11-21 | Smith & Nephew, Inc. | Surgical planning method and characterizations for improved outcomes |
| WO2024243383A1 (en) * | 2023-05-24 | 2024-11-28 | Smith & Nephew, Inc. | Knee arthroplasty implant components |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681589A (en) * | 1984-06-01 | 1987-07-21 | Tronzo Raymond G | Adjustable acetabular cup prosthesis as part of a total cup replacement system |
| US4944757A (en) * | 1988-11-07 | 1990-07-31 | Martinez David M | Modulator knee prosthesis system |
| US5318571A (en) * | 1992-05-14 | 1994-06-07 | Benson Gail M | Method and apparatus for simplifying total hip arthroplasty |
| US5423828A (en) * | 1992-05-14 | 1995-06-13 | Bentwood Place, Inc. | Method and apparatus for simplifying prosthetic joint replacements |
| US5507824A (en) * | 1993-02-23 | 1996-04-16 | Lennox; Dennis W. | Adjustable prosthetic socket component, for articulating anatomical joints |
| US5782925A (en) * | 1997-11-06 | 1998-07-21 | Howmedica Inc. | Knee implant rotational alignment apparatus |
| US6494913B1 (en) * | 1998-03-17 | 2002-12-17 | Acumed, Inc. | Shoulder prosthesis |
| US6063091A (en) * | 1998-10-13 | 2000-05-16 | Stryker Technologies Corporation | Methods and tools for tibial intermedullary revision surgery and associated tibial components |
| US6355045B1 (en) * | 2000-12-28 | 2002-03-12 | Depuy Orthopaedics, Inc. | Method and apparatus for surgically preparing a tibia for implantation of a prosthetic implant component which has an offset stem |
| DE60314096T2 (de) * | 2002-03-11 | 2008-01-24 | Spinal Concepts, Inc., Austin | Einrichtung zum einsetzen von wirbelsäulenimplantaten |
| US6645215B1 (en) * | 2002-08-07 | 2003-11-11 | Howmedica Osteonics Corp. | Tibial rotation guide |
| WO2010121147A1 (en) | 2009-04-16 | 2010-10-21 | Conformis, Inc. | Patient-specific joint arthroplasty devices for ligament repair |
| US8840616B2 (en) * | 2009-05-29 | 2014-09-23 | Smith & Nephew, Inc. | Methods and apparatus for performing knee arthroplasty |
| US9256776B2 (en) * | 2009-11-18 | 2016-02-09 | AI Cure Technologies, Inc. | Method and apparatus for identification |
| US8986390B2 (en) | 2011-06-30 | 2015-03-24 | Depuy (Ireland) | Method of trialing a knee prosthesis |
| EP2739251A4 (en) * | 2011-08-03 | 2015-07-29 | Conformis Inc | AUTOMATED DESIGN, SELECTION, MANUFACTURE AND IMPLANTATION OF PATIENT ADAPTED AND IMPROVED JOINT IMPLANTS, DESIGNS AND RELATED GUIDING TOOLS |
| CA2847857A1 (en) * | 2011-08-15 | 2013-02-21 | Conformis, Inc. | Revision systems, tools and methods for revising joint arthroplasty implants |
| CN108309393B (zh) * | 2012-05-24 | 2024-09-20 | 捷迈有限公司 | 用于关节修复的患者特异性器械和方法 |
| US9675471B2 (en) * | 2012-06-11 | 2017-06-13 | Conformis, Inc. | Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components |
| JP6563418B2 (ja) | 2014-04-14 | 2019-08-21 | ラシュワン マフホウズ，モハメド | 動態位置合わせ並びに新規な大腿骨人工装具及び脛骨人口装具 |
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2015
- 2015-04-14 JP JP2016562592A patent/JP6563418B2/ja active Active
- 2015-04-14 WO PCT/US2015/025822 patent/WO2015160852A1/en not_active Ceased
- 2015-04-14 US US14/686,685 patent/US9901463B2/en active Active
- 2015-04-14 CA CA2945799A patent/CA2945799C/en active Active
- 2015-04-14 ES ES15779900T patent/ES2987433T3/es active Active
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2017
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| CA3077879A1 (en) | 2015-10-22 |
| US9901463B2 (en) | 2018-02-27 |
| WO2015160852A1 (en) | 2015-10-22 |
| EP3131483A4 (en) | 2017-10-25 |
| EP3131483B1 (en) | 2024-05-08 |
| CA2945799A1 (en) | 2015-10-22 |
| US20230285165A9 (en) | 2023-09-14 |
| US20160008143A1 (en) | 2016-01-14 |
| EP3131483A1 (en) | 2017-02-22 |
| JP6862506B2 (ja) | 2021-04-21 |
| JP2017511207A (ja) | 2017-04-20 |
| US11045330B2 (en) | 2021-06-29 |
| US20180055655A1 (en) | 2018-03-01 |
| US20220183856A1 (en) | 2022-06-16 |
| JP2019195689A (ja) | 2019-11-14 |
| JP6563418B2 (ja) | 2019-08-21 |
| CA2945799C (en) | 2020-06-02 |
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