ES2982757T3 - Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos - Google Patents

Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos Download PDF

Info

Publication number
ES2982757T3
ES2982757T3 ES17859121T ES17859121T ES2982757T3 ES 2982757 T3 ES2982757 T3 ES 2982757T3 ES 17859121 T ES17859121 T ES 17859121T ES 17859121 T ES17859121 T ES 17859121T ES 2982757 T3 ES2982757 T3 ES 2982757T3
Authority
ES
Spain
Prior art keywords
acid
thiolated
composition
carbon
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17859121T
Other languages
English (en)
Spanish (es)
Inventor
Bruce Freeman
Nicholas Khoo
Francisco Schopfer
Steven Woodcock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Application granted granted Critical
Publication of ES2982757T3 publication Critical patent/ES2982757T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES17859121T 2016-10-05 2017-10-04 Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos Active ES2982757T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662404368P 2016-10-05 2016-10-05
PCT/US2017/055149 WO2018067705A1 (en) 2016-10-05 2017-10-04 Reversibly protected thiolated electrophilic fatty acids as prodrugs

Publications (1)

Publication Number Publication Date
ES2982757T3 true ES2982757T3 (es) 2024-10-17

Family

ID=61832194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17859121T Active ES2982757T3 (es) 2016-10-05 2017-10-04 Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos

Country Status (7)

Country Link
US (3) US10744106B2 (enExample)
EP (1) EP3522884B1 (enExample)
JP (1) JP2019529501A (enExample)
CN (1) CN109803648A (enExample)
CA (1) CA3039376A1 (enExample)
ES (1) ES2982757T3 (enExample)
WO (1) WO2018067705A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018067709A1 (en) 2016-10-05 2018-04-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Novel reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions
US12390435B2 (en) 2018-11-14 2025-08-19 University of Pittsburgh—of the Commonwealth System of Higher Education Electrophiles and electrophile pro-drugs as RAD51 inhibitors
WO2021242758A1 (en) * 2020-05-26 2021-12-02 Imara Inc. Improved nitro-fatty acid oral dose regimens
CN117586160B (zh) * 2023-11-28 2026-06-23 中国药科大学 一种含硫前药化合物及其医药用途
CN118845745B (zh) * 2024-09-25 2024-12-17 浙江大学医学院附属第二医院 辛酸钠在制备治疗脓毒症药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2679224A1 (en) 2007-08-01 2014-01-01 University of Pittsburgh of the Commonwealth System of Higher Education Nitro oleic acid modulation of type II diabetes
WO2010014889A2 (en) 2008-08-01 2010-02-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Nitro fatty acids as regiomers and related mimetics
CA2769624C (en) 2009-07-31 2018-09-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Electrophilic fatty acid derivatives as anti-inflammatory agents
WO2013116753A1 (en) 2012-02-03 2013-08-08 University Of Pittsburgh-Of The Commonwelth System Of Higher Education Fatty acids as anti-inflammatory agents
US10751310B2 (en) 2016-03-04 2020-08-25 University of Pittsburgh—of the Commonwealth System of Higher Education Prevention, treatment and reversal of disease using therapeutically effective amounts of dicarboxylic acid compounds
WO2018067709A1 (en) 2016-10-05 2018-04-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Novel reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions

Also Published As

Publication number Publication date
EP3522884A1 (en) 2019-08-14
EP3522884C0 (en) 2024-05-29
US20200352890A1 (en) 2020-11-12
EP3522884A4 (en) 2020-05-27
WO2018067705A1 (en) 2018-04-12
JP2019529501A (ja) 2019-10-17
US20230321022A1 (en) 2023-10-12
US10744106B2 (en) 2020-08-18
US20190282527A1 (en) 2019-09-19
CN109803648A (zh) 2019-05-24
CA3039376A1 (en) 2018-04-12
EP3522884B1 (en) 2024-05-29

Similar Documents

Publication Publication Date Title
US20230321022A1 (en) Reversibly protected thiolated electrophilic fatty acids as prodrugs
Das et al. Codrug: An efficient approach for drug optimization
ES2692291T3 (es) Ácidos grasos vinil sustituidos
KR101601987B1 (ko) 신장 보호제로서 중쇄 길이 지방산 및 글리세라이드
US20150094292A1 (en) Topical compositions containing nitro fatty acids
CN102307464A (zh) 含有硝基脂肪酸的营养制品
WO2011041639A2 (en) Heteroatom containing substituted fatty acids
AU2021205027A1 (en) Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids
JP2015508065A (ja) 抗炎症薬としての脂肪酸
JP7448961B2 (ja) チエノピリジン化合物の混合ジスルフィド結合体及びそれらの使用
US11491128B2 (en) Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions
CA3039030C (en) Novel reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions
JP2023141229A (ja) 高リン血症治療用医薬用組成物