ES2982757T3 - Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos - Google Patents

Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos Download PDF

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Publication number
ES2982757T3
ES2982757T3 ES17859121T ES17859121T ES2982757T3 ES 2982757 T3 ES2982757 T3 ES 2982757T3 ES 17859121 T ES17859121 T ES 17859121T ES 17859121 T ES17859121 T ES 17859121T ES 2982757 T3 ES2982757 T3 ES 2982757T3
Authority
ES
Spain
Prior art keywords
acid
thiolated
composition
carbon
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17859121T
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English (en)
Spanish (es)
Inventor
Bruce Freeman
Nicholas Khoo
Francisco Schopfer
Steven Woodcock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
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Publication of ES2982757T3 publication Critical patent/ES2982757T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES17859121T 2016-10-05 2017-10-04 Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos Active ES2982757T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662404368P 2016-10-05 2016-10-05
PCT/US2017/055149 WO2018067705A1 (en) 2016-10-05 2017-10-04 Reversibly protected thiolated electrophilic fatty acids as prodrugs

Publications (1)

Publication Number Publication Date
ES2982757T3 true ES2982757T3 (es) 2024-10-17

Family

ID=61832194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17859121T Active ES2982757T3 (es) 2016-10-05 2017-10-04 Acidos grasos electrofílicos tiolados reversiblemente protegidos como profármacos

Country Status (7)

Country Link
US (3) US10744106B2 (enExample)
EP (1) EP3522884B1 (enExample)
JP (1) JP2019529501A (enExample)
CN (1) CN109803648A (enExample)
CA (1) CA3039376A1 (enExample)
ES (1) ES2982757T3 (enExample)
WO (1) WO2018067705A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019529517A (ja) 2016-10-05 2019-10-17 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ニトロソ化およびアルキル化反応を媒介するニトロアルケンの新規可逆的窒素酸化物誘導体
WO2020102529A1 (en) 2018-11-14 2020-05-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Electrophiles and electrophile pro-drugs as rad51 inhibitors
WO2021242758A1 (en) * 2020-05-26 2021-12-02 Imara Inc. Improved nitro-fatty acid oral dose regimens
CN118845745B (zh) * 2024-09-25 2024-12-17 浙江大学医学院附属第二医院 辛酸钠在制备治疗脓毒症药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324277B2 (en) 2007-08-01 2012-12-04 University of Pittsburgh—of the Commonwealth System of Higher Education Nitrated-fatty acids modulation of type II diabetes
WO2010014889A2 (en) 2008-08-01 2010-02-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Nitro fatty acids as regiomers and related mimetics
JP2013500966A (ja) 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
US20150018417A1 (en) 2012-02-03 2015-01-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acids as anti-inflammatory agents
JP6959246B2 (ja) 2016-03-04 2021-11-02 ユニバーシティ オブ ピッツバーグ−オブ ザ コモンウェルス システム オブ ハイヤー エデュケーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｐｉｔｔｓｂｕｒｇｈ Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 治療に有効な量のジカルボン酸化合物を使用した、病気の予防、治療及び治癒
JP2019529517A (ja) 2016-10-05 2019-10-17 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ニトロソ化およびアルキル化反応を媒介するニトロアルケンの新規可逆的窒素酸化物誘導体

Also Published As

Publication number Publication date
US20190282527A1 (en) 2019-09-19
US10744106B2 (en) 2020-08-18
EP3522884B1 (en) 2024-05-29
JP2019529501A (ja) 2019-10-17
EP3522884C0 (en) 2024-05-29
US20230321022A1 (en) 2023-10-12
US20200352890A1 (en) 2020-11-12
CN109803648A (zh) 2019-05-24
WO2018067705A1 (en) 2018-04-12
CA3039376A1 (en) 2018-04-12
EP3522884A1 (en) 2019-08-14
EP3522884A4 (en) 2020-05-27

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