CA3039376A1 - Reversibly protected thiolated electrophilic fatty acids as prodrugs - Google Patents

Reversibly protected thiolated electrophilic fatty acids as prodrugs Download PDF

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Publication number
CA3039376A1
CA3039376A1 CA3039376A CA3039376A CA3039376A1 CA 3039376 A1 CA3039376 A1 CA 3039376A1 CA 3039376 A CA3039376 A CA 3039376A CA 3039376 A CA3039376 A CA 3039376A CA 3039376 A1 CA3039376 A1 CA 3039376A1
Authority
CA
Canada
Prior art keywords
fatty acid
thiolated
carbon
fatty acids
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3039376A
Other languages
English (en)
French (fr)
Inventor
Bruce A. Freeman
Nicholas KHOO
Francisco Jose Schopfer
Steven Woodcock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of CA3039376A1 publication Critical patent/CA3039376A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3039376A 2016-10-05 2017-10-04 Reversibly protected thiolated electrophilic fatty acids as prodrugs Pending CA3039376A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404368P 2016-10-05 2016-10-05
US62/404,368 2016-10-05
PCT/US2017/055149 WO2018067705A1 (en) 2016-10-05 2017-10-04 Reversibly protected thiolated electrophilic fatty acids as prodrugs

Publications (1)

Publication Number Publication Date
CA3039376A1 true CA3039376A1 (en) 2018-04-12

Family

ID=61832194

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3039376A Pending CA3039376A1 (en) 2016-10-05 2017-10-04 Reversibly protected thiolated electrophilic fatty acids as prodrugs

Country Status (7)

Country Link
US (3) US10744106B2 (enExample)
EP (1) EP3522884B1 (enExample)
JP (1) JP2019529501A (enExample)
CN (1) CN109803648A (enExample)
CA (1) CA3039376A1 (enExample)
ES (1) ES2982757T3 (enExample)
WO (1) WO2018067705A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118845745A (zh) * 2024-09-25 2024-10-29 浙江大学医学院附属第二医院 辛酸钠在制备治疗脓毒症药物中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019529517A (ja) 2016-10-05 2019-10-17 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ニトロソ化およびアルキル化反応を媒介するニトロアルケンの新規可逆的窒素酸化物誘導体
WO2020102529A1 (en) 2018-11-14 2020-05-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Electrophiles and electrophile pro-drugs as rad51 inhibitors
WO2021242758A1 (en) * 2020-05-26 2021-12-02 Imara Inc. Improved nitro-fatty acid oral dose regimens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324277B2 (en) 2007-08-01 2012-12-04 University of Pittsburgh—of the Commonwealth System of Higher Education Nitrated-fatty acids modulation of type II diabetes
WO2010014889A2 (en) 2008-08-01 2010-02-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Nitro fatty acids as regiomers and related mimetics
JP2013500966A (ja) 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
US20150018417A1 (en) 2012-02-03 2015-01-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acids as anti-inflammatory agents
JP6959246B2 (ja) 2016-03-04 2021-11-02 ユニバーシティ オブ ピッツバーグ−オブ ザ コモンウェルス システム オブ ハイヤー エデュケーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｐｉｔｔｓｂｕｒｇｈ Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 治療に有効な量のジカルボン酸化合物を使用した、病気の予防、治療及び治癒
JP2019529517A (ja) 2016-10-05 2019-10-17 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ニトロソ化およびアルキル化反応を媒介するニトロアルケンの新規可逆的窒素酸化物誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118845745A (zh) * 2024-09-25 2024-10-29 浙江大学医学院附属第二医院 辛酸钠在制备治疗脓毒症药物中的应用

Also Published As

Publication number Publication date
US20190282527A1 (en) 2019-09-19
US10744106B2 (en) 2020-08-18
EP3522884B1 (en) 2024-05-29
JP2019529501A (ja) 2019-10-17
EP3522884C0 (en) 2024-05-29
US20230321022A1 (en) 2023-10-12
US20200352890A1 (en) 2020-11-12
CN109803648A (zh) 2019-05-24
WO2018067705A1 (en) 2018-04-12
ES2982757T3 (es) 2024-10-17
EP3522884A1 (en) 2019-08-14
EP3522884A4 (en) 2020-05-27

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Legal Events

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EEER Examination request

Effective date: 20220930

EEER Examination request

Effective date: 20220930

EEER Examination request

Effective date: 20220930