ES297978A1 - Procedure for the manufacture of derivatives of 18-o-acil-17-hydroxy-yohimbano (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the manufacture of derivatives of 18-o-acil-17-hydroxy-yohimbano (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Roche Diagnostics GmbH
CF Boehringer und Soehne GmbH
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Boehringer Mannheim GmbH
CF Boehringer und Soehne GmbH
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Application filed by Boehringer Mannheim GmbH, CF Boehringer und Soehne GmbHfiledCriticalBoehringer Mannheim GmbH
Publication of ES297978A1publicationCriticalpatent/ES297978A1/en
Process for the manufacture of 18-0-acyl-17-hydroxy-yohimban derivatives of the general formula I ** (See formula) ** wherein Ac means the remainder of an organic carboxylic acid or sulfonic acid, hydrogen R or a methoxy group and R1 a lower alkyl moiety, characterized in that the acids of the general formula II or the corresponding 3-epi-acids IIa ** (See formula) ** where R has the above meaning, they are transferred to the 17-oxi- γ -lactone of the formula III ** (See formula) ** the C17-hydroxyl group of the γ -lactone III is protected with an easily dissociable group, stable to the alkalies, the compound thus obtained of the formula IV ** (See formula) ** wherein X represents the protecting group and R has the above meaning, is transformed by alcoholysis into the 18-oxy-ester of the formula V ** (See formula) ** the latter is transferred by esterification to the acyl compounds of the general formula VI ** (See formula) ** wherein Ac, X, R and R1 have the above meaning, and then the protective group X is dissociated. (Machine-translation by Google Translate, not legally binding)
ES0297978A1963-03-281964-03-24Procedure for the manufacture of derivatives of 18-o-acil-17-hydroxy-yohimbano (Machine-translation by Google Translate, not legally binding)
ExpiredES297978A1
(en)
Procedure for the preparation of new derivatives of d treo - 1 - phenyl - 2 - amino - 1,3 - propandiol. (Machine-translation by Google Translate, not legally binding)
New compounds constituted by the acid quinazolon-4-carboxilico-2, its salts, esters and other derivatives and its manufacturing procedure. (Machine-translation by Google Translate, not legally binding)