ES2974577T3 - Compuestos éster y carbonato de pirimidina como inhibidores de JAK quinasa - Google Patents
Compuestos éster y carbonato de pirimidina como inhibidores de JAK quinasa Download PDFInfo
- Publication number
- ES2974577T3 ES2974577T3 ES20726591T ES20726591T ES2974577T3 ES 2974577 T3 ES2974577 T3 ES 2974577T3 ES 20726591 T ES20726591 T ES 20726591T ES 20726591 T ES20726591 T ES 20726591T ES 2974577 T3 ES2974577 T3 ES 2974577T3
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- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- alkyl
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Classifications
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- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
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| US201962837829P | 2019-04-24 | 2019-04-24 | |
| PCT/US2020/029465 WO2020219639A1 (en) | 2019-04-24 | 2020-04-23 | Ester and carbonate pyrimidine compounds as jak kinase inhibitors |
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| ES2974577T3 true ES2974577T3 (es) | 2024-06-27 |
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| ES20726591T Active ES2974577T3 (es) | 2019-04-24 | 2020-04-23 | Compuestos éster y carbonato de pirimidina como inhibidores de JAK quinasa |
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| JP7470713B2 (ja) * | 2019-04-24 | 2024-04-18 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ｊａｋキナーゼ阻害剤としてのエステルおよびカルボナートピリミジン化合物 |
| JP7482152B2 (ja) * | 2019-04-24 | 2024-05-13 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | 皮膚疾患の処置のためのピリミジンｊａｋ阻害剤 発明の背景 |
| US20210212962A1 (en) * | 2020-01-13 | 2021-07-15 | Sol-Gel Technologies Ltd. | Methods and compositions for the treatment of granuloma annulare or subcutaneous inflammation and non-infection granulomatous diseases |
| AU2022263067A1 (en) * | 2021-04-22 | 2023-11-02 | Shenzhen Chipscreen Biosciences Co., Ltd. | Pharmaceutical composition containing jak3/jak1/tbk1 selective inhibitor and medical use thereof |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
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| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2001290912A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| BR0116493A (pt) | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| ATE508126T1 (de) | 2005-11-16 | 2011-05-15 | Vertex Pharma | Als kinaseinhibitoren geeignete aminopyrimidine |
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| AU2007269540B2 (en) | 2006-07-05 | 2013-06-27 | Exelixis, Inc. | Methods of using IGF1R and Abl kinase modulators |
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| WO2015094803A1 (en) | 2013-12-16 | 2015-06-25 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
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| ES2924698T3 (es) | 2015-05-28 | 2022-10-10 | Theravance Biopharma R&D Ip Llc | Proceso e intermedios para la preparación de compuestos de naftiridina como inhibidores de quinasa JAK |
| WO2017189822A1 (en) | 2016-04-28 | 2017-11-02 | Theravance Biopharma R&D Ip, Llc | Pyrimidine compounds as jak kinase inhibitors |
| MA49956B1 (fr) | 2017-10-27 | 2022-11-30 | Theravance Biopharma R&D Ip Llc | Composés de pyrimidine utilisés en tant qu'inhibiteurs de kinase jak |
| TWI740288B (zh) | 2018-11-27 | 2021-09-21 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| CN115925705B (zh) | 2018-11-30 | 2024-12-31 | 江苏豪森药业集团有限公司 | 杂芳类衍生物调节剂、其制备方法和应用 |
| JP7482152B2 (ja) | 2019-04-24 | 2024-05-13 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | 皮膚疾患の処置のためのピリミジンｊａｋ阻害剤 発明の背景 |
| JP7470713B2 (ja) | 2019-04-24 | 2024-04-18 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ｊａｋキナーゼ阻害剤としてのエステルおよびカルボナートピリミジン化合物 |
| CN113372364B (zh) | 2020-03-10 | 2024-05-31 | 明慧医药（上海）有限公司 | 一类jak激酶抑制剂及其制备和应用 |
| CN113372351A (zh) | 2020-03-10 | 2021-09-10 | 明慧医药（杭州）有限公司 | 一类jak激酶抑制剂及其制备和应用 |
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- 2020-04-23 HU HUE20726591A patent/HUE066802T2/hu unknown
- 2020-04-23 US US16/856,280 patent/US11155549B2/en active Active
-
2021
- 2021-09-27 US US17/448,922 patent/US11845747B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11155549B2 (en) | 2021-10-26 |
| EP3958969B1 (en) | 2024-01-10 |
| TW202106682A (zh) | 2021-02-16 |
| PL3958969T3 (pl) | 2024-05-20 |
| HRP20240346T1 (hr) | 2024-05-24 |
| JP7470713B2 (ja) | 2024-04-18 |
| CA3135383A1 (en) | 2020-10-29 |
| US20220009926A1 (en) | 2022-01-13 |
| EP3958969C0 (en) | 2024-01-10 |
| WO2020219639A1 (en) | 2020-10-29 |
| AR118768A1 (es) | 2021-10-27 |
| JP2022529370A (ja) | 2022-06-21 |
| US20200339580A1 (en) | 2020-10-29 |
| HUE066802T2 (hu) | 2024-09-28 |
| EP3958969A1 (en) | 2022-03-02 |
| US11845747B2 (en) | 2023-12-19 |
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