ES296793A1 - Novel 5-acyloxyuracils - Google Patents

Novel 5-acyloxyuracils

Info

Publication number
ES296793A1
ES296793A1 ES0296793A ES296793A ES296793A1 ES 296793 A1 ES296793 A1 ES 296793A1 ES 0296793 A ES0296793 A ES 0296793A ES 296793 A ES296793 A ES 296793A ES 296793 A1 ES296793 A1 ES 296793A1
Authority
ES
Spain
Prior art keywords
formula
pyrazole
acyloxyuracils
unreduced
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0296793A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES296793A1 publication Critical patent/ES296793A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 5-acyloxyuracils of formula <FORM:0991988/C2/1> where R is a nitrogen-containing, unreduced heterocyclic ring system of formula <FORM:0991988/C2/2> in which a is -CH= or -N= and b is =CH-CH=, =CH- or =C(CH3)-, e.g. pyridine or pyrazole. They are prepared by acylating 5-hydroxyuracil with RCOX, X being a proton-accepting radical such as chlorine, or a reactive amide group formed from RCOOH and 1,11-dicarbonydimidazole or the corresponding pyrazole, triazole or tetrazole. The products inhibit antibody formation.ALSO:Pharmaceutical compositions for inhibiting antibody formation comprise 5-acyloxyuracils of formula <FORM:0991988/A5-A6/1> where R is a nitrogen-containing, unreduced heterocyclic ring system of formula <FORM:0991988/A5-A6/2> in which a is -CH= or -N= and b is =CH-CH=, =CH- or =C(CH3)-, e.g. pyridine or pyrazole. The uracils may be combined with 6-substituted purines with anti-immune activity such as 6-mercaptopurine. Oral, parenteral and topical preparations may be formulated, e.g. tablets, capsules, cachets, ampoules, suppositories, powders, granules, solutions, suspensions or ointments.
ES0296793A 1963-02-25 1964-02-24 Novel 5-acyloxyuracils Expired ES296793A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7554/63A GB991988A (en) 1963-02-25 1963-02-25 Novel 5-acyloxyuracils

Publications (1)

Publication Number Publication Date
ES296793A1 true ES296793A1 (en) 1964-09-01

Family

ID=9835358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0296793A Expired ES296793A1 (en) 1963-02-25 1964-02-24 Novel 5-acyloxyuracils

Country Status (10)

Country Link
AT (1) AT252261B (en)
BE (1) BE644200A (en)
CH (1) CH448101A (en)
DE (1) DE1237123B (en)
DK (1) DK107751C (en)
ES (1) ES296793A1 (en)
FR (1) FR3487M (en)
GB (1) GB991988A (en)
NL (1) NL6401717A (en)
SE (1) SE305875B (en)

Also Published As

Publication number Publication date
DE1237123B (en) 1967-03-23
SE305875B (en) 1968-11-11
NL6401717A (en) 1964-08-26
FR3487M (en) 1965-08-16
BE644200A (en) 1964-08-21
CH448101A (en) 1967-12-15
DK107751C (en) 1967-07-03
GB991988A (en) 1965-05-12
AT252261B (en) 1967-02-10

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