ES2967371T3 - Composición criodesecada para preparar microvesículas llenas de gas calibradas - Google Patents

Composición criodesecada para preparar microvesículas llenas de gas calibradas Download PDF

Info

Publication number
ES2967371T3
ES2967371T3 ES20761497T ES20761497T ES2967371T3 ES 2967371 T3 ES2967371 T3 ES 2967371T3 ES 20761497 T ES20761497 T ES 20761497T ES 20761497 T ES20761497 T ES 20761497T ES 2967371 T3 ES2967371 T3 ES 2967371T3
Authority
ES
Spain
Prior art keywords
cryo
microvesicles
gas
suspension
calibrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20761497T
Other languages
English (en)
Spanish (es)
Inventor
Anne Lassus
Samir Cherkaoui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Application granted granted Critical
Publication of ES2967371T3 publication Critical patent/ES2967371T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
ES20761497T 2019-06-25 2020-06-24 Composición criodesecada para preparar microvesículas llenas de gas calibradas Active ES2967371T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19182226 2019-06-25
PCT/EP2020/067756 WO2020260423A1 (en) 2019-06-25 2020-06-24 Freeze-dried composition for preparing calibrated gas-filled microvesicles

Publications (1)

Publication Number Publication Date
ES2967371T3 true ES2967371T3 (es) 2024-04-30

Family

ID=67070596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20761497T Active ES2967371T3 (es) 2019-06-25 2020-06-24 Composición criodesecada para preparar microvesículas llenas de gas calibradas

Country Status (7)

Country Link
US (1) US20220409749A1 (https=)
EP (1) EP3990033B1 (https=)
JP (2) JP7712877B2 (https=)
CN (1) CN114007656A (https=)
DK (1) DK3990033T3 (https=)
ES (1) ES2967371T3 (https=)
WO (1) WO2020260423A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12233131B2 (en) 2021-07-14 2025-02-25 Bracco Suisse Sa Cationic calibrated-size gas-filled microvesicles
NL2033467B1 (en) * 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
CN120529925A (zh) 2022-12-21 2025-08-22 博莱科瑞士股份有限公司 含全氟烯烃的充气微泡
WO2025073838A1 (en) * 2023-10-04 2025-04-10 Bracco Suisse Sa Freeze-drying process
WO2025125516A1 (en) 2023-12-13 2025-06-19 Bracco Suisse Sa Calibrated gas-filled microvesicles with ligand
WO2025252942A1 (en) 2024-06-06 2025-12-11 Bracco Suisse Sa Anionic gas-filled microvesicles with calibrated sizes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029782A1 (en) 1996-02-19 1997-08-21 Nycomed Imaging A/S Thermally stabilized contrast agent
JP4670083B2 (ja) * 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
US9555136B2 (en) * 2010-06-21 2017-01-31 University Of Washington Through Its Center For Commercialization Coated magnetic nanoparticles
GB201405735D0 (en) 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
CN105999314B (zh) * 2016-07-11 2018-12-18 四川省人民医院 一种超声造影剂及其制备方法
US10918605B2 (en) * 2016-08-30 2021-02-16 Bracco Suisse Sa Preparation of size-controlled microparticles

Also Published As

Publication number Publication date
JP2022538769A (ja) 2022-09-06
JP2025118720A (ja) 2025-08-13
WO2020260423A1 (en) 2020-12-30
EP3990033A1 (en) 2022-05-04
JP7712877B2 (ja) 2025-07-24
EP3990033B1 (en) 2023-12-06
CN114007656A (zh) 2022-02-01
DK3990033T3 (da) 2023-12-18
US20220409749A1 (en) 2022-12-29

Similar Documents

Publication Publication Date Title
ES2967371T3 (es) Composición criodesecada para preparar microvesículas llenas de gas calibradas
US9364569B2 (en) Ultrasound contrast agents and process for the preparation thereof
US9446156B2 (en) Gas-filled microvesicles with polymer-modified lipids
ES2908708T3 (es) Preparación de micropartículas de tamaño controlado
ES2967186T3 (es) Composición liofilizada para preparar microvesículas llenas de gas calibradas
ES3002682T3 (en) Preparation of size-controlled microvesicles
ES2726924T3 (es) Formulación de microvesículas dirigidas rellenas de gas