ES2967259T3 - Detección y tratamiento de la deficiencia de la hormona del crecimiento - Google Patents

Detección y tratamiento de la deficiencia de la hormona del crecimiento Download PDF

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Publication number
ES2967259T3
ES2967259T3 ES21192867T ES21192867T ES2967259T3 ES 2967259 T3 ES2967259 T3 ES 2967259T3 ES 21192867 T ES21192867 T ES 21192867T ES 21192867 T ES21192867 T ES 21192867T ES 2967259 T3 ES2967259 T3 ES 2967259T3
Authority
ES
Spain
Prior art keywords
test
child
use according
growth
ghd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES21192867T
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English (en)
Spanish (es)
Inventor
Michael Thorner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumos Pharma Inc
Original Assignee
Lumos Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumos Pharma Inc filed Critical Lumos Pharma Inc
Application granted granted Critical
Publication of ES2967259T3 publication Critical patent/ES2967259T3/es
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/61Growth hormones [GH] (Somatotropin)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
ES21192867T 2015-09-21 2016-09-21 Detección y tratamiento de la deficiencia de la hormona del crecimiento Active ES2967259T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562221191P 2015-09-21 2015-09-21
US201662289221P 2016-01-30 2016-01-30

Publications (1)

Publication Number Publication Date
ES2967259T3 true ES2967259T3 (es) 2024-04-29

Family

ID=58276481

Family Applications (2)

Application Number Title Priority Date Filing Date
ES21192867T Active ES2967259T3 (es) 2015-09-21 2016-09-21 Detección y tratamiento de la deficiencia de la hormona del crecimiento
ES16849470T Active ES2908423T3 (es) 2015-09-21 2016-09-21 Detección y tratamiento de la deficiencia de la hormona del crecimiento

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES16849470T Active ES2908423T3 (es) 2015-09-21 2016-09-21 Detección y tratamiento de la deficiencia de la hormona del crecimiento

Country Status (23)

Country Link
US (5) US9763919B2 (https=)
EP (3) EP3352752B1 (https=)
JP (5) JP6816149B2 (https=)
KR (4) KR20250102122A (https=)
CN (2) CN116459250A (https=)
AU (5) AU2016328969B2 (https=)
CA (1) CA2998523C (https=)
CY (1) CY1125183T1 (https=)
DK (2) DK3939590T3 (https=)
ES (2) ES2967259T3 (https=)
FI (1) FI3939590T3 (https=)
HR (1) HRP20220317T1 (https=)
HU (2) HUE057831T2 (https=)
IL (1) IL258224B (https=)
LT (1) LT3352752T (https=)
PL (2) PL3352752T3 (https=)
PT (2) PT3939590T (https=)
RS (1) RS62988B1 (https=)
SG (2) SG10202010598SA (https=)
SI (1) SI3352752T1 (https=)
SM (1) SMT202200167T1 (https=)
UA (1) UA123865C2 (https=)
WO (1) WO2017053373A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11234969B2 (en) * 2016-01-30 2022-02-01 Lumos Pharma, Inc. Detecting and treating growth hormone deficiency
HUE057831T2 (hu) * 2015-09-21 2022-06-28 Lumos Pharma Inc Növekedési hormon hiányának felismerése és kezelése
US10288629B1 (en) * 2017-12-19 2019-05-14 Aeterna Zentaris, Inc. Method of assessing growth hormone deficiency in humans by a macimorelin containing composition
WO2020041322A1 (en) 2018-08-20 2020-02-27 Berkowitz Barry A Novel cannabinoids and cannabinoid acids and their derivatives
US11644474B2 (en) * 2020-07-22 2023-05-09 Æterna Zentaris Gmbh Use of macimorelin in assessing growth hormone deficiency in children
KR20250107210A (ko) * 2022-11-03 2025-07-11 루모스 파마, 인크. 이부타모렌의 압축형 경구 제형

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000759A1 (en) * 1992-06-29 1994-01-06 University Of South Florida Diagnostic procedure for evaluating short stature etiology
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ATE344667T1 (de) 1997-08-22 2006-11-15 Kaken Pharma Co Ltd Amide zur förderung der ausschüttung von wachstumshormonen
ATE446758T1 (de) 2000-05-31 2009-11-15 Pfizer Prod Inc Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts
AR029941A1 (es) 2000-06-13 2003-07-23 Zentaris Gmbh Compuestos utiles para elevar el nivel plasmatico de la hormona del crecimiento y las composiciones farmaceuticas que las contienen
BRPI0414175A (pt) * 2003-09-19 2006-10-31 Pfizer Health Ab método melhorado de tratamento de distúrbios do crescimento
NZ547752A (en) 2003-11-12 2009-12-24 Phenomix Corp Heterocyclic boronic acid compounds for inhibiting dipeptidyl peptidase-IV
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
WO2013163455A2 (en) * 2012-04-25 2013-10-31 The Regents Of The University Of California A drug screening platform for rett syndrome
US11234969B2 (en) * 2016-01-30 2022-02-01 Lumos Pharma, Inc. Detecting and treating growth hormone deficiency
HUE057831T2 (hu) * 2015-09-21 2022-06-28 Lumos Pharma Inc Növekedési hormon hiányának felismerése és kezelése

Also Published As

Publication number Publication date
KR102560838B1 (ko) 2023-07-27
JP7724831B2 (ja) 2025-08-18
PT3939590T (pt) 2024-01-23
JP7104768B2 (ja) 2022-07-21
AU2021254600A1 (en) 2021-11-18
KR20220047407A (ko) 2022-04-15
IL258224A (en) 2018-05-31
AU2020233715A1 (en) 2020-10-22
PL3352752T3 (pl) 2022-04-19
JP6816149B2 (ja) 2021-01-20
KR20230116961A (ko) 2023-08-04
US20190015394A1 (en) 2019-01-17
JP2024026112A (ja) 2024-02-28
EP3939590A1 (en) 2022-01-19
PT3352752T (pt) 2022-03-09
US10105352B2 (en) 2018-10-23
DK3939590T3 (da) 2023-12-18
NZ741142A (en) 2025-05-02
AU2024201658A1 (en) 2024-04-04
FI3939590T3 (fi) 2023-12-14
SI3352752T1 (sl) 2022-05-31
AU2024201658C1 (en) 2026-02-12
AU2025237934A1 (en) 2025-10-16
US20180071266A1 (en) 2018-03-15
KR102385669B1 (ko) 2022-04-13
HUE065224T2 (hu) 2024-05-28
JP7389862B2 (ja) 2023-11-30
IL258224B (en) 2021-10-31
HUE057831T2 (hu) 2022-06-28
CN116459250A (zh) 2023-07-21
US10898472B2 (en) 2021-01-26
JP2021063096A (ja) 2021-04-22
EP3352752A1 (en) 2018-08-01
UA123865C2 (uk) 2021-06-16
EP4296679A3 (en) 2024-04-10
AU2020233715B2 (en) 2021-09-30
CA2998523C (en) 2023-08-01
US20220142989A1 (en) 2022-05-12
US20250213536A1 (en) 2025-07-03
HRP20220317T1 (hr) 2022-05-13
PL3939590T3 (pl) 2024-03-25
HK1263178A1 (zh) 2020-01-31
LT3352752T (lt) 2022-04-11
ES2908423T3 (es) 2022-04-29
EP3939590B1 (en) 2023-11-29
KR20250102122A (ko) 2025-07-04
KR20180082428A (ko) 2018-07-18
US20170079961A1 (en) 2017-03-23
RS62988B1 (sr) 2022-03-31
AU2016328969A1 (en) 2018-04-26
CN108348501A (zh) 2018-07-31
EP3352752A4 (en) 2019-06-12
SG10201902424TA (en) 2019-04-29
CY1125183T1 (el) 2023-06-09
EP3352752B1 (en) 2021-12-22
SMT202200167T1 (it) 2022-05-12
DK3352752T3 (da) 2022-02-28
SG10202010598SA (en) 2020-11-27
JP2022163012A (ja) 2022-10-25
CA2998523A1 (en) 2017-03-30
JP2018529766A (ja) 2018-10-11
WO2017053373A1 (en) 2017-03-30
AU2021254600B2 (en) 2024-02-15
AU2016328969B2 (en) 2020-10-08
US9763919B2 (en) 2017-09-19
EP4296679A2 (en) 2023-12-27
US12539293B2 (en) 2026-02-03
AU2024201658B2 (en) 2025-10-30
JP2025170274A (ja) 2025-11-18

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