ES2962812T3 - Células madre mesenquimatosas modificadas genéticamente que sobreexpresan AOAH y sus usos - Google Patents
Células madre mesenquimatosas modificadas genéticamente que sobreexpresan AOAH y sus usos Download PDFInfo
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- ES2962812T3 ES2962812T3 ES19878837T ES19878837T ES2962812T3 ES 2962812 T3 ES2962812 T3 ES 2962812T3 ES 19878837 T ES19878837 T ES 19878837T ES 19878837 T ES19878837 T ES 19878837T ES 2962812 T3 ES2962812 T3 ES 2962812T3
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- aoah
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
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- General Health & Medical Sciences (AREA)
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- Biomedical Technology (AREA)
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- Biochemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201862752000P | 2018-10-29 | 2018-10-29 | |
| PCT/CA2019/051526 WO2020087160A1 (en) | 2018-10-29 | 2019-10-29 | Genetically-engineered mesenchymal stem cells overexpressing aoah and uses thereof |
Publications (1)
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|---|---|
| ES2962812T3 true ES2962812T3 (es) | 2024-03-21 |
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| ES19878837T Active ES2962812T3 (es) | 2018-10-29 | 2019-10-29 | Células madre mesenquimatosas modificadas genéticamente que sobreexpresan AOAH y sus usos |
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| Country | Link |
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| US (1) | US20220010281A1 (enExample) |
| EP (1) | EP3874029B1 (enExample) |
| JP (1) | JP7372982B2 (enExample) |
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| ES (1) | ES2962812T3 (enExample) |
| IL (1) | IL282820A (enExample) |
| SG (1) | SG11202103509RA (enExample) |
| WO (1) | WO2020087160A1 (enExample) |
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| AU2021360131A1 (en) * | 2020-10-16 | 2023-05-25 | Ottawa Hospital Research Institute | Cell-based therapy for viral diseases |
| CN116570711A (zh) * | 2022-12-21 | 2023-08-11 | 上海交通大学医学院附属第九人民医院 | 酰基羧酸水解酶在制备治疗肾脏纤维化疾病的药物中的应用 |
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| US4929604A (en) * | 1986-05-28 | 1990-05-29 | Board Of Regents, The University Of Texas System | Lipopolysaccharides of reduced toxicity and the production thereof |
| US5281520A (en) * | 1990-09-12 | 1994-01-25 | Zymogenetics, Inc. | Method for producing acyloxyacyl hydrolase |
| CN101378764A (zh) * | 2005-12-09 | 2009-03-04 | 贝勒研究院 | 通过血液白细胞微阵列分析对系统性红斑狼疮的诊断、预后和疾病发展的监测 |
| AU2009275135A1 (en) * | 2008-07-21 | 2010-01-28 | Compugen Ltd. | Angiopoietin derived peptides |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| BRPI1015179A2 (pt) * | 2009-06-19 | 2016-04-19 | Merck Patent Gmbh | biomarcadores e métodos para a determinação de eficácia de anticorpos anti-egfr em terapia de câncer |
| EP2626369A1 (en) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Engineered mesenchymal stem cells and their therapeutic use |
| CA2859452C (en) * | 2012-03-27 | 2021-12-21 | Curevac Gmbh | Artificial nucleic acid molecules for improved protein or peptide expression |
| WO2013151663A1 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| AU2014342162B2 (en) * | 2013-11-01 | 2020-01-02 | Regeneron Pharmaceuticals, Inc. | Angiopoietin-based interventions for treating cerebral malaria |
| EP3087101B1 (en) * | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| NZ727950A (en) * | 2014-06-30 | 2022-07-01 | Takeda Pharmaceuticals Co | Mesenchymal stromal cells for treating sepsis |
| LT3242933T (lt) * | 2015-01-08 | 2019-06-25 | Apceth Gmbh & Co. Kg | Genetiškai modifikuotos mezenchiminės kamieninės ląstelės, ekspresuojančios alfa-1 antitripsiną (aat) |
| JP7269733B2 (ja) * | 2015-06-12 | 2023-05-09 | レンティジェン・テクノロジー・インコーポレイテッド | 操作されたｔ細胞を用いて癌を処置するための方法 |
| EP3351254A4 (en) * | 2015-09-15 | 2019-07-17 | Kangstem Biotech Co., Ltd. | COMPOSITION FOR THE PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES WITH SOD3 OVEREXPRIMATING STEM CELLS AS AN ACTIVE SUBSTANCE |
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| WO2020087160A1 (en) | 2020-05-07 |
| JP2022513379A (ja) | 2022-02-07 |
| AU2019370629A1 (en) | 2021-05-20 |
| EP3874029A1 (en) | 2021-09-08 |
| IL282820A (en) | 2021-06-30 |
| CN113166729A (zh) | 2021-07-23 |
| SG11202103509RA (en) | 2021-05-28 |
| US20220010281A1 (en) | 2022-01-13 |
| EP3874029A4 (en) | 2022-08-03 |
| EP3874029B1 (en) | 2023-08-30 |
| CA3116196A1 (en) | 2020-05-07 |
| KR20210086662A (ko) | 2021-07-08 |
| JP7372982B2 (ja) | 2023-11-01 |
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